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anti-TFEB antibody :: Rabbit anti-Human, Mouse TFEB Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2538354
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TFEB, Polyclonal Antibody

★Popular Item★
 Also Known As   

TFEB Polyclonal Antibody

 Product Synonym Names    TFEB; BHLHE35; Transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35
 Product Gene Name   

anti-TFEB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600744
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Affinity purification
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the N-terminal region of human TFEB.
 Buffer    PBS with 0.02% sodium azide, 50% glycerol and 0.5% BSA
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-11004 / sc-11005 / sc-48784
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-TFEB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TFEB antibody

   TFEB (Transcription Factor EB) is a Protein Coding gene. Diseases associated with TFEB include Renal Cell Carcinoma, Papillary and Microphthalmia. Among its related pathways are Apoptosis and Autophagy and PI3K-AKT-mTOR signaling pathway and therapeutic opportunities. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is MITF.
 Product Categories/Family for anti-TFEB antibody    Cancer
 Applications Tested/Suitable for anti-TFEB antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-TFEB antibody    WB: 1:500-1:2000, IHC: 1:50-1:200, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-TFEB antibody    Western Blot analysis of mouse-lung mouse-muscle cells using TFEB Polyclonal Antibody
anti-TFEB antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TFEB. It may not necessarily be applicable to this product.
 NCBI GI #    429836865
 NCBI GeneID    7942
 NCBI Accession #    NP_001161299.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001167827.2 [Other Products]
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 UniProt Secondary Accession #    Q709B3; Q7Z6P9; Q9BRJ5; Q9UJD8 [Other Products]
 UniProt Related Accession #    P19484 [Other Products]
 Molecular Weight    Calculated MW: 53
Observed MW: 52
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 NCBI Official Full Name    transcription factor EB isoform 2
 NCBI Official Synonym Full Names    transcription factor EB
 NCBI Official Symbol    TFEB [Similar Products]
 NCBI Official Synonym Symbols   
TCFEB; BHLHE35; ALPHATFEB
[Similar Products]
 NCBI Protein Information    transcription factor EB
 UniProt Protein Name    Transcription factor EB
 UniProt Synonym Protein Names   
Class E basic helix-loop-helix protein 35; bHLHe35
 Protein Family    Transcription factor
 UniProt Gene Name    TFEB [Similar Products]
 UniProt Synonym Gene Names    BHLHE35; bHLHe35 [Similar Products]
 UniProt Entry Name    TFEB_HUMAN
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 UniProt Comments for TFEB    TFEB: Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Homodimer and heterodimer; with TFE3 or MITF. Belongs to the MiT/TFE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: cytoplasm; nucleus

Molecular Function: protein dimerization activity; transcription factor activity

Biological Process: adaptive immune response; autophagy; embryonic placenta development; humoral immune response; lysosome organization and biogenesis; positive regulation of autophagy; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription, DNA-dependent
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 Research Articles on TFEB    1. TFEB modulates autophagic clearance of alpha-syn
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TFEB antibodyDiseases associated with anti-TFEB antibody
 Reference Product  PubMed Publications
 TFE3 antibody  >79 publications with TFEB and TFE3
 MITF antibody  >56 publications with TFEB and MITF
 TFEC antibody  >20 publications with TFEB and TFEC
 PRCC antibody  >10 publications with TFEB and PRCC
 PPARGC1A antibody  >9 publications with TFEB and PPARGC1A
 CTSK antibody  >4 publications with TFEB and CTSK
 WT1 antibody  >2 publications with TFEB and WT1
 SMAD7 antibody  >1 publications with TFEB and SMAD7
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >54 publications with TFEB and Kidney Diseases
 Adenocarcinoma Antibodies  >53 publications with TFEB and Adenocarcinoma
 Nervous System Diseases Antibodies  >26 publications with TFEB and Nervous System Diseases
 Brain Diseases Antibodies  >19 publications with TFEB and Brain Diseases
 Heart Diseases Antibodies  >9 publications with TFEB and Heart Diseases
 Necrosis Antibodies  >8 publications with TFEB and Necrosis
 Liver Diseases Antibodies  >7 publications with TFEB and Liver Diseases
 Atrophy Antibodies  >6 publications with TFEB and Atrophy
 Congenital Abnormalities Antibodies  >6 publications with TFEB and Congenital Abnormalities
 Lung Diseases Antibodies  >5 publications with TFEB and Lung Diseases
Organs/Tissues associated with anti-TFEB antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >58 publications with TFEB and Kidney
 Muscle Antibodies  >24 publications with TFEB and Muscle
 Blood Antibodies  >19 publications with TFEB and Blood
 Brain Antibodies  >19 publications with TFEB and Brain
 Lung Antibodies  >11 publications with TFEB and Lung
 Bone Antibodies  >9 publications with TFEB and Bone
 Placenta Antibodies  >8 publications with TFEB and Placenta
 Eye Antibodies  >7 publications with TFEB and Eye
 Skin Antibodies  >5 publications with TFEB and Skin
 Lymph Antibodies  >3 publications with TFEB and Lymph
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