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anti-TFEB antibody :: Goat TFEB Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420811
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
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 Product Name   

TFEB, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-TFEB (N Terminus) Antibody

 Product Synonym Names    Goat Anti-TFEB (internal) Antibody; TFEB; transcription factor EB; TCFEB; T-cell transcription factor EB; RP4-696P19.3; AlphaTFEB; TCFEB; bHLHe35; OTTHUMP00000043540; TFEB antibody; transcription factor EB antibody; TCFEB antibody; T-cell transcription factor EB antibody; RP4-696P19.3 antibody; AlphaTFEB antibody; TCFEB antibody; bHLHe35 antibody; OTTHUMP00000043540 antibody; TFEB (N Terminus)
 Product Gene Name   

anti-TFEB antibody

[Similar Products]
 Antibody/Peptide Pairs    TFEB peptide (MBS428090) is used for blocking the activity of TFEB antibody (MBS420811)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600744
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human;
Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
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 Immunogen    Peptide with sequence ASRIGLRMQLMRE-C, from the N Terminus of the protein sequence according to NP_009093.1.NP_001161299.2; NP_001258872.1
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 Preparation and Storage    Aliquot and store at -20C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-TFEB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TFEB antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

 Application Notes for anti-TFEB antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.

Western Blot: Aprox.55kDa band observed in Human Thymus and in lysates of cell line Jurkat and approx. 60 kDa in lysates of cell line HeLa, (calculated MW of 52.9 kDa according to NP_009093.1 and 54.2 kDa according to NP_001161299.2)Recommended concentration:0.3-1 ug/mL.Primary incubation 1 hour at room temperature.

Chromatin Immunoprecipitation: This antibody was confirmed in ChIP on SK-MEL-5 cells. This antibody was obtained from a previous batch (different goat).
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 Testing Data TD of anti-TFEB antibody    MBS420811(0.5 ug/mL)staining of HeLa (A) and(0.3ug/mL) Jurkat(B)Cell lysate(35 ug protein in RIPA buffer).Detected by chemiluminescence.
anti-TFEB antibody Testing Data TD image
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 Testing Data TD of anti-TFEB antibody    MBS420811 (1.0 ug/mL) staining of Human Thymus lysate (35 ug protein in RIPA buffer). Detected by chemiluminescence.
anti-TFEB antibody Testing Data TD image
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NCBI/Uniprot data below describe general gene information for TFEB. It may not necessarily be applicable to this product.
 NCBI GI #    24307933
 NCBI GeneID    7942
 NCBI Accession #    NP_009093.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007162.2 [Other Products]
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 UniProt Secondary Accession #    Q709B3; Q7Z6P9; Q9BRJ5; Q9UJD8 [Other Products]
 UniProt Related Accession #    P19484 [Other Products]
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 NCBI Official Full Name    transcription factor EB isoform 1
 NCBI Official Synonym Full Names    transcription factor EB
 NCBI Official Symbol    TFEB [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    transcription factor EB
 UniProt Protein Name    Transcription factor EB
 UniProt Synonym Protein Names   
Class E basic helix-loop-helix protein 35; bHLHe35
 Protein Family    Transcription factor
 UniProt Gene Name    TFEB [Similar Products]
 UniProt Synonym Gene Names    BHLHE35; bHLHe35 [Similar Products]
 UniProt Entry Name    TFEB_HUMAN
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 UniProt Comments for TFEB    TFEB: Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Homodimer and heterodimer; with TFE3 or MITF. Belongs to the MiT/TFE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: cytoplasm; nucleus

Molecular Function: protein dimerization activity; transcription factor activity

Biological Process: adaptive immune response; autophagy; embryonic placenta development; humoral immune response; lysosome organization and biogenesis; positive regulation of autophagy; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription, DNA-dependent
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 Research Articles on TFEB    1. during mitophagy TFEB translocates to the nucleus and displays transcriptional activity in a PINK1- and Parkin-dependent manner.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TFEB antibodyDiseases associated with anti-TFEB antibody
 Reference Product  PubMed Publications
 TFE3 antibody  >92 publications with TFEB and TFE3
 MITF antibody  >61 publications with TFEB and MITF
 TFEC antibody  >20 publications with TFEB and TFEC
 PRCC antibody  >11 publications with TFEB and PRCC
 PPARGC1A antibody  >10 publications with TFEB and PPARGC1A
 CTSK antibody  >4 publications with TFEB and CTSK
 WT1 antibody  >2 publications with TFEB and WT1
 SMAD7 antibody  >1 publications with TFEB and SMAD7
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >56 publications with TFEB and Kidney Diseases
 Adenocarcinoma Antibodies  >55 publications with TFEB and Adenocarcinoma
 Nervous System Diseases Antibodies  >30 publications with TFEB and Nervous System Diseases
 Brain Diseases Antibodies  >24 publications with TFEB and Brain Diseases
 Heart Diseases Antibodies  >11 publications with TFEB and Heart Diseases
 Liver Diseases Antibodies  >8 publications with TFEB and Liver Diseases
 Necrosis Antibodies  >8 publications with TFEB and Necrosis
 Lung Diseases Antibodies  >7 publications with TFEB and Lung Diseases
 Inflammation Antibodies  >7 publications with TFEB and Inflammation
 Atrophy Antibodies  >6 publications with TFEB and Atrophy
Organs/Tissues associated with anti-TFEB antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >61 publications with TFEB and Kidney
 Muscle Antibodies  >25 publications with TFEB and Muscle
 Brain Antibodies  >22 publications with TFEB and Brain
 Blood Antibodies  >20 publications with TFEB and Blood
 Lung Antibodies  >12 publications with TFEB and Lung
 Bone Antibodies  >10 publications with TFEB and Bone
 Placenta Antibodies  >8 publications with TFEB and Placenta
 Eye Antibodies  >7 publications with TFEB and Eye
 Skin Antibodies  >6 publications with TFEB and Skin
 Lymph Antibodies  >3 publications with TFEB and Lymph
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