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anti-TFEC antibody :: Goat TFEC Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420738
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TFEC, Polyclonal Antibody

 Also Known As   

Goat anti-TFEC Antibody

 Product Synonym Names    TFEC; transcription factor EC; TCFEC; TFECL; bHLHe34; TFEC antibody; transcription factor EC antibody; TCFEC antibody; TFECL antibody; bHLHe34 antibody
 Product Gene Name   

anti-TFEC antibody

[Similar Products]
 Antibody/Peptide Pairs    TFEC peptide (MBS425377) is used for blocking the activity of TFEC antibody (MBS420738)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    TLDHQIINPT LK
 OMIM    604732
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence TLDHQIINPTLK-C, from the N Terminus of the protein sequence according to NP_036384.1; NP_001018068.1.
 Epitope    N Terminus
 Note    This antibody is expected to recognise both reported Human isoforms according to NP_036384.1 and NP_001018068.1.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-TFEC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TFEC antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TFEC antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 40-45kDa band seen in Human Testis lysate. Recommended for use at 0.5-2ug/ml.
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 Western Blot (WB) of anti-TFEC antibody    Staining (1ug/ml) of Human Testis lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-TFEC antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TFEC. It may not necessarily be applicable to this product.
 NCBI GI #    6912702
 NCBI GeneID    22797
 NCBI Accession #    NP_036384.1 [Other Products]
 NCBI Related Accession #    NP_001018068.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012252.3 [Other Products]
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 UniProt Secondary Accession #    Q5H9U8; Q709A4; Q8N6J9; B2R8X5 [Other Products]
 UniProt Related Accession #    O14948 [Other Products]
 Molecular Weight    31,558 Da
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 NCBI Official Full Name    transcription factor EC isoform a
 NCBI Official Synonym Full Names    transcription factor EC
 NCBI Official Symbol    TFEC [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    transcription factor EC
 UniProt Protein Name    Transcription factor EC
 UniProt Synonym Protein Names   
Class E basic helix-loop-helix protein 34; bHLHe34; Transcription factor EC-like; hTFEC-L
 Protein Family    Transcription factor
 UniProt Gene Name    TFEC [Similar Products]
 UniProt Synonym Gene Names    BHLHE34; TCFEC; TFECL; TFE-C; bHLHe34; hTFEC-L [Similar Products]
 UniProt Entry Name    TFEC_HUMAN
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 NCBI Summary for TFEC    This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
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 UniProt Comments for TFEC    TFEC: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer. Binds DNA in a homo- or heterodimeric form. Belongs to the MiT/TFE family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 7q31.2

Cellular Component: cytoplasm; nucleoplasm

Molecular Function: DNA binding; protein binding; protein dimerization activity; transcription coactivator activity; transcription corepressor activity; transcription factor activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
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 Research Articles on TFEC    1. Two alternatively spliced TFEC isoforms have been found to be sequence-specific transcriptional activators of the nonmuscle myosin II heavy chain-A gene in transfected cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TFEC antibodyPathways associated with anti-TFEC antibody
 Reference Product  PubMed Publications
 MITF antibody  >24 publications with TFEC and MITF
 TFE3 antibody  >23 publications with TFEC and TFE3
 TFEB antibody  >20 publications with TFEC and TFEB
 CTSK antibody  >3 publications with TFEC and CTSK
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
Diseases associated with anti-TFEC antibodyOrgans/Tissues associated with anti-TFEC antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >9 publications with TFEC and Kidney Diseases
 Necrosis Antibodies  >7 publications with TFEC and Necrosis
 Acute Kidney Injury Antibodies  >2 publications with TFEC and Acute Kidney Injury
 Drug-Induced Liver Injury Antibodies  >2 publications with TFEC and Drug-Induced Liver Injury
 Growth Disorders Antibodies  >1 publications with TFEC and Growth Disorders
 Atrophy Antibodies  >1 publications with TFEC and Atrophy
 Liver Diseases Antibodies  >1 publications with TFEC and Liver Diseases
 Anemia Antibodies  >1 publications with TFEC and Anemia
 Lung Diseases Antibodies  >1 publications with TFEC and Lung Diseases
 Vascular Diseases Antibodies  >1 publications with TFEC and Vascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >32 publications with TFEC and Kidney
 Blood Antibodies  >6 publications with TFEC and Blood
 Thyroid Antibodies  >4 publications with TFEC and Thyroid
 Bone Marrow Antibodies  >2 publications with TFEC and Bone Marrow
 Lung Antibodies  >2 publications with TFEC and Lung
 Placenta Antibodies  >2 publications with TFEC and Placenta
 Connective Tissue Antibodies  >1 publications with TFEC and Connective Tissue
 Lymph Antibodies  >1 publications with TFEC and Lymph
 Ovary Antibodies  >1 publications with TFEC and Ovary
 Brain Antibodies  >1 publications with TFEC and Brain
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