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anti-TGFB1 antibody :: Rabbit TGF beta 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS820639
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TGF beta 1 (TGFB1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-TGF beta 1 Antibody

 Product Synonym Names    TGFB; Transforming growth factor beta-1; TGF-beta-1
 Product Gene Name   

anti-TGFB1 antibody

[Similar Products]
 Antibody/Peptide Pairs    TGF beta 1 peptide (MBS823587) is used for blocking the activity of TGF beta 1 antibody (MBS820639)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 190180
 3D Structure    ModBase 3D Structure for P01137
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Bovine, Dog, Pig, Sheep
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 Specificity    Recognizes endogenous levels of TGF beta 1 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TGF beta 1. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-TGFB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TGFB1 antibody

   Rabbit polyclonal antibody to TGF beta 1
 Applications Tested/Suitable for anti-TGFB1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)

 Application Notes for anti-TGFB1 antibody    WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/ICC (1/100 - 1/500), IP (1/10 - 1/100)
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 Western Blot (WB) of anti-TGFB1 antibody    Western blot analysis of TGF beta 1 expression in HeLa (A), MCF7 (B), SP2/0 (C), H9C2 (D) whole cell lysates.
anti-TGFB1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TGFB1 antibody    Immunohistochemical analysis of TGF beta 1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-TGFB1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence/Immunocytochemistry (IF/ICC) of anti-TGFB1 antibody    Immunofluorescent analysis of TGF beta 1 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 degree C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
anti-TGFB1 antibody Immunofluorescence/Immunocytochemistry (IF/ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for TGFB1. It may not necessarily be applicable to this product.
 NCBI GI #    63025222
 NCBI GeneID    7040
 NCBI Accession #    NP_000651.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000660.5 [Other Products]
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 UniProt Primary Accession #    P01137 [Other Products]
 UniProt Secondary Accession #    Q9UCG4; A8K792 [Other Products]
 UniProt Related Accession #    P01137 [Other Products]
 Molecular Weight    44,341 Da
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 NCBI Official Full Name    transforming growth factor beta-1
 NCBI Official Synonym Full Names    transforming growth factor, beta 1
 NCBI Official Symbol    TGFB1 [Similar Products]
 NCBI Official Synonym Symbols   
CED; LAP; DPD1; TGFB; TGFbeta
[Similar Products]
 NCBI Protein Information    transforming growth factor beta-1; TGF-beta-1; latency-associated peptide; prepro-transforming growth factor beta-1
 UniProt Protein Name    Transforming growth factor beta-1
 Protein Family    Transforming growth factor
 UniProt Gene Name    TGFB1 [Similar Products]
 UniProt Synonym Gene Names    TGFB; TGF-beta-1; LAP [Similar Products]
 UniProt Entry Name    TGFB1_HUMAN
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 NCBI Summary for TGFB1    This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]
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 UniProt Comments for TGFB1    TGFB1: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Homodimer; disulfide-linked, or heterodimer with TGFB2. Secreted and stored as a biologically inactive form in the extracellular matrix in a 290 kDa complex (large latent TGF-beta1 complex) containing the TGFB1 homodimer, the latency-associated peptide (LAP), and the latent TGFB1 binding protein-1 (LTBP1). The complex without LTBP1 is known as the'small latent TGF-beta1 complex'. Dissociation of the TGFB1 from LAP is required for growth factor activation and biological activity. Release of the large latent TGF-beta1 complex from the extracellular matrix is carried out by the matrix metalloproteinase MMP3. May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly and attenuation of TGFB signaling. Interacts with the serine proteases, HTRA1 and HTRA3: the interaction with either inhibits TGFB1-mediated signaling. The HTRA protease activity is required for this inhibition. Interacts with CD109, DPT and ASPN. Activated in vitro at pH below 3.5 and over 12.5. Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: proteinaceous extracellular matrix; extracellular space; microvillus; cell surface; cell soma; Golgi lumen; axon; cytoplasm; plasma membrane; extracellular region; nucleus

Molecular Function: protein binding; enzyme binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; punt binding; cytokine activity; protein N-terminus binding; glycoprotein binding; antigen binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; SMAD protein nuclear translocation; female pregnancy; positive regulation of protein amino acid dephosphorylation; activation of NF-kappaB transcription factor; regulation of protein import into nucleus; positive regulation of MAP kinase activity; connective tissue replacement during inflammatory response; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of ossification; cell cycle arrest; inner ear development; positive regulation of isotype switching to IgA isotypes; regulatory T cell differentiation; positive regulation of interleukin-17 production; response to drug; positive regulation of smooth muscle cell differentiation; positive regulation of chemotaxis; active induction of host immune response by virus; positive regulation of blood vessel endothelial cell migration; regulation of sodium ion transport; negative regulation of blood vessel endothelial cell migration; negative regulation of fat cell differentiation; lymph node development; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; response to progesterone stimulus; endoderm development; positive regulation of odontogenesis; myelination; negative regulation of phagocytosis; evasion of host defenses by virus; positive regulation of cellular protein metabolic process; myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; phosphate metabolic process; negative regulation of cell proliferation; negative regulation of T cell proliferation; regulation of DNA binding; ureteric bud development; negative regulation of release of sequestered calcium ion into cytosol; positive regulation of cell proliferation; salivary gland morphogenesis; protein kinase B signaling cascade; protein export from nucleus; inflammatory response; positive regulation of exit from mitosis; aging; epidermal growth factor receptor signaling pathway; mitotic cell cycle checkpoint; common-partner SMAD protein phosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of bone mineralization; positive regulation of peptidyl-serine phosphorylation; SMAD protein complex assembly; positive regulation of protein kinase B signaling cascade; positive regulation of protein complex assembly; positive regulation of protein import into nucleus; response to hypoxia; epithelial to mesenchymal transition; negative regulation of cell growth; negative regulation of cell-cell adhesion; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of skeletal muscle development; mononuclear cell proliferation; regulation of cell migration; protein amino acid phosphorylation; hyaluronan catabolic process; regulation of apoptosis; response to vitamin D; negative regulation of neuroblast proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of superoxide release; receptor catabolic process; germ cell migration; response to glucose stimulus; chondrocyte differentiation; T cell homeostasis; negative regulation of mitotic cell cycle; defense response to fungus, incompatible interaction; cell growth; tolerance induction to self antigen; regulation of striated muscle development; platelet activation; organ regeneration; negative regulation of DNA replication; virus-host interaction; hemopoietic progenitor cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation; positive regulation of collagen biosynthetic process; viral infectious cycle; response to estradiol stimulus; negative regulation of cell cycle; response to radiation; positive regulation of histone deacetylation; platelet degranulation; negative regulation of protein amino acid phosphorylation; lipopolysaccharide-mediated signaling pathway; response to wounding; adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; negative regulation of epithelial cell proliferation; intercellular junction assembly and maintenance; regulation of binding; MAPKKK cascade; cellular calcium ion homeostasis; gut development; protein import into nucleus, translocation; ATP biosynthetic process; positive regulation of histone acetylation; positive regulation of protein amino acid phosphorylation; blood coagulation; negative regulation of myoblast differentiation; positive regulation of cell migration

Disease: Camurati-engelmann Disease; Cystic Fibrosis
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 Research Articles on TGFB1    1. These results suggest that miR-218 regulates the ability of TGFbeta to induce myofibroblast differentiation in fibroblasts via cezanne/FAK.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TGFB1 antibodyPathways associated with anti-TGFB1 antibody
 Reference Product  PubMed Publications
 SMAD2 antibody  >1315 publications with TGFB1 and SMAD2
 SMAD7 antibody  >533 publications with TGFB1 and SMAD7
 TGFBR3 antibody  >96 publications with TGFB1 and TGFBR3
 DCN antibody  >84 publications with TGFB1 and DCN
 TIMP1 antibody  >75 publications with TGFB1 and TIMP1
 TGFBR2 antibody  >67 publications with TGFB1 and TGFBR2
 TGFBR1 antibody  >61 publications with TGFB1 and TGFBR1
 LTBP1 antibody  >48 publications with TGFB1 and LTBP1
 FN1 antibody  >22 publications with TGFB1 and FN1
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
Diseases associated with anti-TGFB1 antibodyOrgans/Tissues associated with anti-TGFB1 antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >4990 publications with TGFB1 and Fibrosis
 Lung Diseases Antibodies  >1571 publications with TGFB1 and Lung Diseases
 Liver Cirrhosis Antibodies  >854 publications with TGFB1 and Liver Cirrhosis
 Pulmonary Fibrosis Antibodies  >786 publications with TGFB1 and Pulmonary Fibrosis
 Hypertension Antibodies  >727 publications with TGFB1 and Hypertension
 Proteinuria Antibodies  >499 publications with TGFB1 and Proteinuria
 Diabetic Nephropathies Antibodies  >473 publications with TGFB1 and Diabetic Nephropathies
 Hypersensitivity Antibodies  >453 publications with TGFB1 and Hypersensitivity
 Asthma Antibodies  >420 publications with TGFB1 and Asthma
 Neoplasm Metastasis Antibodies  >384 publications with TGFB1 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5453 publications with TGFB1 and Blood
 Muscle Antibodies  >3315 publications with TGFB1 and Muscle
 Kidney Antibodies  >2817 publications with TGFB1 and Kidney
 Bone Antibodies  >2388 publications with TGFB1 and Bone
 Lung Antibodies  >2117 publications with TGFB1 and Lung
 Liver Antibodies  >2008 publications with TGFB1 and Liver
 Connective Tissue Antibodies  >1781 publications with TGFB1 and Connective Tissue
 Heart Antibodies  >1265 publications with TGFB1 and Heart
 Skin Antibodies  >1216 publications with TGFB1 and Skin
 Bone Marrow Antibodies  >813 publications with TGFB1 and Bone Marrow
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