NP_990759.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
TGF-beta receptor type-2
NCBI Official Synonym Full Names
transforming growth factor, beta receptor II (70/80kDa)
NCBI Protein Information
TGF-beta receptor type-2; TGFR-2; tbetaR-II; TGF-beta receptor type II; TGF-beta type II receptor; transforming growth factor-beta receptor type II; transforming growth factor-beta type II receptor
UniProt Protein Name
TGF-beta receptor type-2
UniProt Synonym Protein Names
TGF-beta type II receptor; Transforming growth factor-beta receptor type II
UniProt Synonym Gene Names
UniProt Entry Name
TGFR2_CHICK
UniProt Comments for TGFBR2
Function: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways
By similarity. Ref.1
Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor: Magnesium or manganese
By similarity.
Subunit structure: Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer
By similarity.
Subcellular location: Cell membrane; Single-pass type I membrane protein
By similarity.
Tissue specificity: Detected at low levels in embryonic heart, brain and lung. Detected at high levels in hatchling heart and lung. Ref.1
Post-translational modification: Phosphorylated on a Ser/Thr residue in the cytoplasmic domain
By similarity.
Sequence similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 protein kinase domain.
Research Articles on TGFBR2
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Products associated with anti-TGFBR2 antibody
Pathways associated with anti-TGFBR2 antibody
Diseases associated with anti-TGFBR2 antibody
Organs/Tissues associated with anti-TGFBR2 antibody
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