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anti-TGF beta antibody :: Goat TGF beta Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS534513 anti-TGF beta antibody
Unit / Price
1 mg  /  $775 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TGF beta, Polyclonal Antibody

 Also Known As   

TGF beta antibody

 Product Synonym Names    Polyclonal TGF beta; Anti-TGF beta; TGFB1; Transforming Growth Factor-beta1; TGF beta-1; TGF beta 1; TGF-1b; Differentiation inhibiting factor; Cartilage-inducing factor
 Product Gene Name   

anti-TGF beta antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    121820
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
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 Specificity    Human LAP derived TGF beta 1 precursor
 Form/Format    Lyophilized from a 0.2 um filtered solution in PBS and NaCl with Trehalose.
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 Biological Significance    Transforming growth factor (sometimes referred to as Tumor growth factor, or TGF) is used to describe two classes of polypeptide growth factors, TGF alpha and TGFBeta.
 Bioactivity    ND50 is typically 15-30 ug/ml in the presence of 125 ng/ml of recombinant human LAP TGF beta 1 and 0.25 ng/ml TGF beta 1.
 Endotoxin Levels    <10 ng per 1 mg of the antibody as determined by the LAL method.
 Immunogen    TGF beta antibody was raised in goat using CHO cell-derived recombinant human LAP (TGF-beta1) as the immunogen.
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 Preparation and Storage    Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-TGF beta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TGF beta antibody

   Affinity purified Goat polyclonal TGF beta antibody
 Product Categories/Family for anti-TGF beta antibody    Cytokines & Growth Factors; Purified Polyclonal Antibodies
 Applications Tested/Suitable for anti-TGF beta antibody   

ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB), Neutralization

 Application Notes for anti-TGF beta antibody    FC: 2.5 ug/10^6 cells
IHC: 5-15 ug/ml
ICC: 5-15 ug/ml
WB: 1 ug/ml
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NCBI/Uniprot data below describe general gene information for TGF beta. It may not necessarily be applicable to this product.
 NCBI GI #    254596903
 NCBI GeneID    7045
 NCBI Accession #    ACT75673.1 [Other Products]
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 UniProt Secondary Accession #    O14471; O14472; O14476; O43216; O43217; O43218; O43219; Q53XM1; D3DQB1 [Other Products]
 UniProt Related Accession #    Q15582 [Other Products]
 Molecular Weight    74,681 Da
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 NCBI Official Full Name    transforming growth factor beta, partial
 NCBI Official Synonym Full Names    transforming growth factor, beta-induced, 68kDa
 NCBI Official Symbol    TGFBI [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    transforming growth factor-beta-induced protein ig-h3
 UniProt Protein Name    Transforming growth factor-beta-induced protein ig-h3
 UniProt Synonym Protein Names   
Kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP
 UniProt Gene Name    TGFBI [Similar Products]
 UniProt Synonym Gene Names    BIGH3; Beta ig-h3; RGD-CAP [Similar Products]
 UniProt Entry Name    BGH3_HUMAN
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 NCBI Summary for TGF beta    This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TGF beta    betaIG-H3: Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. By TGFB1. Highly expressed in the corneal epithelium.

Protein type: Extracellular matrix; Secreted; Cell adhesion; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; plasma membrane; extracellular region; basement membrane; trans-Golgi network

Molecular Function: integrin binding; collagen binding; protein binding; extracellular matrix binding

Biological Process: cell proliferation; extracellular matrix organization and biogenesis; visual perception; response to stimulus; chondrocyte differentiation; negative regulation of cell adhesion; angiogenesis; cell adhesion

Disease: Corneal Dystrophy, Epithelial Basement Membrane; Corneal Dystrophy, Lattice Type Iiia; Corneal Dystrophy Of Bowman Layer, Type Ii; Corneal Dystrophy, Avellino Type; Corneal Dystrophy, Lattice Type I; Corneal Dystrophy Of Bowman Layer, Type I; Corneal Dystrophy, Groenouw Type I
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 Research Articles on TGF beta    1. Silencing of DDR1 inhibited tumor cell growth and motility, and induced TGFBI expression, both in vitro and in vivo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TGF beta antibodyDiseases associated with anti-TGF beta antibody
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Lattice corneal dystrophy type 1 Antibodies  >10 publications with TGF beta and Lattice corneal dystrophy type 1
 Inflammation Antibodies  >9 publications with TGF beta and Inflammation
 Lung Diseases Antibodies  >9 publications with TGF beta and Lung Diseases
 Kidney Diseases Antibodies  >8 publications with TGF beta and Kidney Diseases
 Corneal dystrophy Avellino type Antibodies  >8 publications with TGF beta and Corneal dystrophy Avellino type
 Lung Neoplasms Antibodies  >7 publications with TGF beta and Lung Neoplasms
 Groenouw type I corneal dystrophy Antibodies  >5 publications with TGF beta and Groenouw type I corneal dystrophy
 Disease Models, Animal Antibodies  >5 publications with TGF beta and Disease Models, Animal
 Pancreatic Neoplasms Antibodies  >5 publications with TGF beta and Pancreatic Neoplasms
 Liver Diseases Antibodies  >5 publications with TGF beta and Liver Diseases
Organs/Tissues associated with anti-TGF beta antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >132 publications with TGF beta and Eye
 Blood Antibodies  >56 publications with TGF beta and Blood
 Bone Antibodies  >17 publications with TGF beta and Bone
 Lung Antibodies  >13 publications with TGF beta and Lung
 Brain Antibodies  >12 publications with TGF beta and Brain
 Liver Antibodies  >10 publications with TGF beta and Liver
 Kidney Antibodies  >9 publications with TGF beta and Kidney
 Muscle Antibodies  >8 publications with TGF beta and Muscle
 Skin Antibodies  >7 publications with TGF beta and Skin
 Bone Marrow Antibodies  >7 publications with TGF beta and Bone Marrow
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