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anti-TGFBR1 antibody :: Rabbit TGFBR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2530290
Immunohistochemistry (IHC)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TGFBR1, Polyclonal Antibody

★Popular Item★
 Also Known As   

TGFBR1 Polyclonal Antibody

 Product Synonym Names    AAT5; ALK5; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4
 Product Gene Name   

anti-TGFBR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    132800
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    2.6mg/mL (lot specific)
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 Immunogen    Synthetic peptide of human TGFBR1
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TGFBR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TGFBR1 antibody

   The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
 Product Categories/Family for anti-TGFBR1 antibody    Stem cells; Cancer; Epigenetics
 Applications Tested/Suitable for anti-TGFBR1 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-TGFBR1 antibody    IHC: 1:100-1:300
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 Immunohistochemistry (IHC) of anti-TGFBR1 antibody    Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using TGFBR1 Polyclonal Antibody at dilution 1:70
anti-TGFBR1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TGFBR1. It may not necessarily be applicable to this product.
 NCBI GI #    47937325
 NCBI GeneID    7046
 NCBI Accession #    AAH71181.1 [Other Products]
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 UniProt Secondary Accession #    Q6IR47; Q706C0; Q706C1 [Other Products]
 UniProt Related Accession #    P36897 [Other Products]
 Molecular Weight    47,690 Da
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 NCBI Official Full Name    TGFBR1 protein
 NCBI Official Synonym Full Names    transforming growth factor, beta receptor 1
 NCBI Official Symbol    TGFBR1 [Similar Products]
 NCBI Official Synonym Symbols   
AAT5; ALK5; ESS1; LDS1; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4; tbetaR-I
[Similar Products]
 NCBI Protein Information    TGF-beta receptor type-1; activin A receptor type II-like kinase, 53kDa; activin A receptor type II-like protein kinase of 53kD; activin receptor-like kinase 5; serine/threonine-protein kinase receptor R4; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); transforming growth factor-beta receptor type I
 UniProt Protein Name    TGF-beta receptor type-1
 UniProt Synonym Protein Names   
Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I
 Protein Family    TGF-beta receptor
 UniProt Gene Name    TGFBR1 [Similar Products]
 UniProt Synonym Gene Names    ALK5; SKR4; TGFR-1; ALK-5; ALK5; SKR4; TGF-beta receptor type I; TbetaR-I [Similar Products]
 UniProt Entry Name    TGFR1_HUMAN
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 NCBI Summary for TGFBR1    The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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 UniProt Comments for TGFBR1    TGFBR1: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart.

Protein type: Protein kinase, TKL; EC 2.7.11.30; Receptor, misc.; Protein kinase, Ser/Thr (receptor); Kinase, protein; Membrane protein, integral; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: tight junction; membrane; cell; plasma membrane; receptor complex; endosome

Molecular Function: metal ion binding; punt binding; protein kinase activity; transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; transforming growth factor beta binding; growth factor binding; receptor signaling protein activity; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: blastocyst development; collagen fibril organization; activation of MAPKK activity; heart development; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; activin receptor signaling pathway; cell motility involved in cell locomotion; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; extracellular structure organization and biogenesis; transforming growth factor beta receptor signaling pathway; germ cell migration; kidney development; cell cycle arrest; neuron fate commitment; embryonic cranial skeleton morphogenesis; parathyroid gland development; positive regulation of cell growth; endothelial cell activation; mesenchymal cell differentiation; regulation of gene expression; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of endothelial cell proliferation; lens development in camera-type eye; wound healing; regulation of protein ubiquitination; apoptosis; palate development; signal transduction; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; angiogenesis; skeletal development; positive regulation of filopodium formation; pharyngeal system development; thymus development; in utero embryonic development; male gonad development; peptidyl-threonine phosphorylation; positive regulation of cell motility; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; skeletal morphogenesis; regulation of protein binding; epithelial to mesenchymal transition; artery morphogenesis; negative regulation of transforming growth factor beta receptor signaling pathway

Disease: Multiple Self-healing Squamous Epithelioma, Susceptibility To
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 Research Articles on TGFBR1    1. Mutations in genes such as AKT2, CCNA1, MAP3K4, and TGFBR1, were associated significantly with Epstein-Barr-positive gastric tumors, compared with EBV-negative tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TGFBR1 antibodyPathways associated with anti-TGFBR1 antibody
 Reference Product  PubMed Publications
 TGFBR2 antibody  >127 publications with TGFBR1 and TGFBR2
 TGFB1 antibody  >61 publications with TGFBR1 and TGFB1
 SMAD2 antibody  >30 publications with TGFBR1 and SMAD2
 SMAD7 antibody  >15 publications with TGFBR1 and SMAD7
 SMAD4 antibody  >14 publications with TGFBR1 and SMAD4
 TGFB3 antibody  >9 publications with TGFBR1 and TGFB3
 SMURF2 antibody  >1 publications with TGFBR1 and SMURF2
 UBC antibody  >1 publications with TGFBR1 and UBC
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with anti-TGFBR1 antibodyOrgans/Tissues associated with anti-TGFBR1 antibody
 Disease Name  Pubmed Publications
 Loeys-Dietz Syndrome Antibodies  >63 publications with TGFBR1 and Loeys-Dietz Syndrome
 Heart Diseases Antibodies  >50 publications with TGFBR1 and Heart Diseases
 Aneurysm, Dissecting Antibodies  >38 publications with TGFBR1 and Aneurysm, Dissecting
 Colorectal Neoplasms Antibodies  >31 publications with TGFBR1 and Colorectal Neoplasms
 Disease Models, Animal Antibodies  >16 publications with TGFBR1 and Disease Models, Animal
 Inflammation Antibodies  >13 publications with TGFBR1 and Inflammation
 Fibrosis Antibodies  >11 publications with TGFBR1 and Fibrosis
 Lung Diseases Antibodies  >11 publications with TGFBR1 and Lung Diseases
 Lung Neoplasms Antibodies  >8 publications with TGFBR1 and Lung Neoplasms
 Pain Antibodies  >7 publications with TGFBR1 and Pain
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >52 publications with TGFBR1 and Vascular
 Blood Antibodies  >38 publications with TGFBR1 and Blood
 Connective Tissue Antibodies  >38 publications with TGFBR1 and Connective Tissue
 Muscle Antibodies  >31 publications with TGFBR1 and Muscle
 Heart Antibodies  >26 publications with TGFBR1 and Heart
 Lung Antibodies  >26 publications with TGFBR1 and Lung
 Bone Antibodies  >23 publications with TGFBR1 and Bone
 Skin Antibodies  >15 publications with TGFBR1 and Skin
 Embryonic Tissue Antibodies  >13 publications with TGFBR1 and Embryonic Tissue
 Kidney Antibodies  >13 publications with TGFBR1 and Kidney
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