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anti-TGFbeta RI antibody :: Rabbit TGFbeta RI Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9409092
Western Blot (WB)
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TGFbeta RI, Polyclonal Antibody

★Popular Item★
 Also Known As   

TGFbeta RI (Phospho-Ser165) Polyclonal Antibody

 Product Synonym Names    TGFb RI (Phospho-Ser165) Polyclonal Antibody; TGFBR1; ALK5; SKR4; TGF-beta receptor type-1; TGFR-1; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transfor
 Product Gene Name   

anti-TGFbeta RI antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    132800
 3D Structure    ModBase 3D Structure for P36897
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Phospho-TGFb RI (S165) Polyclonal Antibody detects endogenous levels of TGFb RI protein only when phosphorylated at S165.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Immunogen Type    peptide
 Immunogen Description    Synthesized peptide derived from human TGFb RI around the phosphorylation site of S165.
 Modification    Phospho-Ser165
 Target Species    Human
 Target Name    TGFb RI
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-TGFbeta RI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-TGFbeta RI antibody    Phospho-specific Ab
 Applications Tested/Suitable for anti-TGFbeta RI antibody   

Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-TGFbeta RI antibody    Immunofluorescence: 1:200- 1:1000
ELISA: 1:5000
Not yet tested in other applications
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 Western Blot (WB) of anti-TGFbeta RI antibody    Western Blot analysis of MOUSE-LIVER cells using Phospho-TGFb RI (S165) Polyclonal Antibody
anti-TGFbeta RI antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TGFbeta RI. It may not necessarily be applicable to this product.
 NCBI GI #    195963412
 NCBI GeneID    7046
 NCBI Accession #    NP_001124388.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001130916.2 [Other Products]
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 UniProt Primary Accession #    P36897 [Other Products]
 UniProt Secondary Accession #    Q6IR47; Q706C0; Q706C1 [Other Products]
 UniProt Related Accession #    P36897 [Other Products]
 Molecular Weight    47,690 Da
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 NCBI Official Full Name    TGF-beta receptor type-1 isoform 2
 NCBI Official Synonym Full Names    transforming growth factor, beta receptor 1
 NCBI Official Symbol    TGFBR1 [Similar Products]
 NCBI Official Synonym Symbols   
AAT5; ALK5; ESS1; LDS1; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4; tbetaR-I
[Similar Products]
 NCBI Protein Information    TGF-beta receptor type-1
 UniProt Protein Name    TGF-beta receptor type-1
 UniProt Synonym Protein Names   
Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I
 UniProt Gene Name    TGFBR1 [Similar Products]
 UniProt Synonym Gene Names    ALK5; SKR4; TGFR-1; ALK-5; ALK5; SKR4; TGF-beta receptor type I; TbetaR-I [Similar Products]
 UniProt Entry Name    TGFR1_HUMAN
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 NCBI Summary for TGFbeta RI    The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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 UniProt Comments for TGFbeta RI    Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
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 Research Articles on TGFbeta RI    1. Chinese Han family a pathogenic mutation (rs111426349, c.1459C >T) (TGFBR1) of familial thoracic aortic aneurysm was confirmed, which result in the amino acid substitution p.R487W.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TGFbeta RI antibodyPathways associated with anti-TGFbeta RI antibody
 Reference Product  PubMed Publications
 TGFBR2 antibody  >145 publications with TGFbeta RI and TGFBR2
 TGFB1 antibody  >66 publications with TGFbeta RI and TGFB1
 SMAD3 antibody  >46 publications with TGFbeta RI and SMAD3
 SMAD2 antibody  >40 publications with TGFbeta RI and SMAD2
 SMAD4 antibody  >19 publications with TGFbeta RI and SMAD4
 SMAD7 antibody  >15 publications with TGFbeta RI and SMAD7
 TGFB3 antibody  >13 publications with TGFbeta RI and TGFB3
 SMAD6 antibody  >2 publications with TGFbeta RI and SMAD6
 UBC antibody  >1 publications with TGFbeta RI and UBC
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with anti-TGFbeta RI antibodyOrgans/Tissues associated with anti-TGFbeta RI antibody
 Disease Name  Pubmed Publications
 Loeys-Dietz Syndrome Antibodies  >68 publications with TGFbeta RI and Loeys-Dietz Syndrome
 Heart Diseases Antibodies  >55 publications with TGFbeta RI and Heart Diseases
 Aneurysm, Dissecting Antibodies  >44 publications with TGFbeta RI and Aneurysm, Dissecting
 Colorectal Neoplasms Antibodies  >33 publications with TGFbeta RI and Colorectal Neoplasms
 Fibrosis Antibodies  >15 publications with TGFbeta RI and Fibrosis
 Inflammation Antibodies  >15 publications with TGFbeta RI and Inflammation
 Lung Diseases Antibodies  >13 publications with TGFbeta RI and Lung Diseases
 Neoplasms, Experimental Antibodies  >10 publications with TGFbeta RI and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >9 publications with TGFbeta RI and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >8 publications with TGFbeta RI and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >60 publications with TGFbeta RI and Vascular
 Blood Antibodies  >43 publications with TGFbeta RI and Blood
 Connective Tissue Antibodies  >42 publications with TGFbeta RI and Connective Tissue
 Muscle Antibodies  >35 publications with TGFbeta RI and Muscle
 Heart Antibodies  >31 publications with TGFbeta RI and Heart
 Bone Antibodies  >27 publications with TGFbeta RI and Bone
 Lung Antibodies  >27 publications with TGFbeta RI and Lung
 Skin Antibodies  >17 publications with TGFbeta RI and Skin
 Embryonic Tissue Antibodies  >15 publications with TGFbeta RI and Embryonic Tissue
 Kidney Antibodies  >14 publications with TGFbeta RI and Kidney
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