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anti-TGN46 antibody :: Rabbit anti-Primate TGN46 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS223325 anti-TGN46 antibody
Unit / Price
0.1 mL  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TGN46, Polyclonal Antibody

 Also Known As   

RABBIT ANTI HUMAN TGN46

 Product Gene Name   

anti-TGN46 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603062
 3D Structure    ModBase 3D Structure for O43493
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Primate
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 Form/Format    Serum
Serum - liquid
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 Perservative Stabilisers    0.02% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
 Antiserum Preparation    Antisera to human TGN46 were raised by repeated immunisation of rabbits with highly purified recombinant human TGN46.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-TGN46 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TGN46 antibody

   Rabbit anti Human TGN46 antibody recognizes Trans-Golgi network integral membrane protein 2, also known as TGN46, TGN38 homolog or Trans-Golgi network protein TGN51. TGN46 is a 480 amino acid ~110kDa single pass type I transmembrane glycoprotein associated with the trans golgi network membrane. TGN46 has been reported as being the best available marker for human trans-Golgi network.
 Applications Tested/Suitable for anti-TGN46 antibody   

Immunofluorescence (IF)*, Western Blot (WB)

 Application Notes for anti-TGN46 antibody    Immunofluorescence: Minimum Dilution: 1/50; Maximum Dilution: 1/100; Application Note: Fixation of tissues with 3% paraformaldehyde or methanol is recommended prior to using this antibody on immunofluorescence.
Western Blotting: Minimum Dilution: 1/500; Maximum Dilution: 1/000
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NCBI/Uniprot data below describe general gene information for TGN46. It may not necessarily be applicable to this product.
 NCBI GI #    332205947
 NCBI GeneID    10618
 NCBI Accession #    NP_001193769.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206840.1 [Other Products]
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 UniProt Primary Accession #    O43493 [Other Products]
 UniProt Secondary Accession #    O15282; O43492; O43499; O43500; O43501; Q53G68; Q53GV2; B2R686; B8ZZ88; D6W5K3; F8WBK2 [Other Products]
 UniProt Related Accession #    O43493 [Other Products]
 Molecular Weight    29,541 Da
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 NCBI Official Full Name    trans-Golgi network integral membrane protein 2 isoform 2
 NCBI Official Synonym Full Names    trans-golgi network protein 2
 NCBI Official Symbol    TGOLN2 [Similar Products]
 NCBI Official Synonym Symbols   
TGN38; TGN46; TGN48; TGN51; TTGN2
[Similar Products]
 NCBI Protein Information    trans-Golgi network integral membrane protein 2; TGN38 homolog; trans-Golgi network protein (46, 48, 51kD isoforms); trans-Golgi network protein TGN51
 UniProt Protein Name    Trans-Golgi network integral membrane protein 2
 UniProt Synonym Protein Names   
TGN38 homolog; TGN46; TGN48; Trans-Golgi network protein TGN51
 UniProt Gene Name    TGOLN2 [Similar Products]
 UniProt Synonym Gene Names    TGN46; TGN51 [Similar Products]
 UniProt Entry Name    TGON2_HUMAN
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 NCBI Summary for TGN46    This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for TGN46    TGOLN2: May be involved in regulating membrane traffic to and from trans-Golgi network. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p11.2

Cellular Component: nucleoplasm; Golgi apparatus; transport vesicle; plasma membrane; integral to membrane; trans-Golgi network

Molecular Function: protein binding
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 Research Articles on TGN46    1. These results indicate that hepatitis E virus (HEV)forms membrane-associated particles in the cytoplasm, and that the released HEV particles with a lipid membrane retain the antigenicity of TGOLN2 on their surface.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TGN46 antibodyDiseases associated with anti-TGN46 antibody
 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >7 publications with TGN46 and Brain Diseases
 Disease Models, Animal Antibodies  >4 publications with TGN46 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >3 publications with TGN46 and Cardiovascular Diseases
 Lung Diseases Antibodies  >2 publications with TGN46 and Lung Diseases
 Inflammation Antibodies  >2 publications with TGN46 and Inflammation
 Skin Diseases Antibodies  >1 publications with TGN46 and Skin Diseases
 Movement Disorders Antibodies  >1 publications with TGN46 and Movement Disorders
 Cell Transformation, Neoplastic Antibodies  >1 publications with TGN46 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >1 publications with TGN46 and Liver Diseases
 Fibrosis Antibodies  >1 publications with TGN46 and Fibrosis
Organs/Tissues associated with anti-TGN46 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >29 publications with TGN46 and Brain
 Nerve Antibodies  >16 publications with TGN46 and Nerve
 Kidney Antibodies  >12 publications with TGN46 and Kidney
 Liver Antibodies  >6 publications with TGN46 and Liver
 Blood Antibodies  >5 publications with TGN46 and Blood
 Muscle Antibodies  >4 publications with TGN46 and Muscle
 Heart Antibodies  >4 publications with TGN46 and Heart
 Skin Antibodies  >2 publications with TGN46 and Skin
 Lung Antibodies  >2 publications with TGN46 and Lung
 Vascular Antibodies  >2 publications with TGN46 and Vascular
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