NP_060575.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
THAP domain-containing protein 1 isoform 1
NCBI Official Synonym Full Names
THAP domain containing 1
NCBI Official Synonym Symbols
NCBI Protein Information
THAP domain-containing protein 1
UniProt Protein Name
THAP domain-containing protein 1
NCBI Summary for THAP1
The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
UniProt Comments for THAP1
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Research Articles on THAP1
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Products associated with anti-THAP1 antibody
Diseases associated with anti-THAP1 antibody
Organs/Tissues associated with anti-THAP1 antibody
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