NP_000452.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,449 Da
NCBI Official Full Name
thyroid hormone receptor beta
NCBI Official Synonym Full Names
thyroid hormone receptor, beta
NCBI Official Synonym Symbols
GRTH; PRTH; THR1; ERBA2; NR1A2; THRB1; THRB2; C-ERBA-2; C-ERBA-BETA [Similar Products]
NCBI Protein Information
thyroid hormone receptor beta; oncogene ERBA2; nuclear receptor subfamily 1 group A member 2; thyroid hormone nuclear receptor beta variant 1; thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
UniProt Protein Name
Thyroid hormone receptor beta
UniProt Synonym Protein Names
Nuclear receptor subfamily 1 group A member 2; c-erbA-2; c-erbA-beta
UniProt Synonym Gene Names
UniProt Entry Name
THB_HUMAN
NCBI Summary for THRB
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for THRB
TR-beta1: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Homolog of the viral oncogene erbB. Two splice variant isoforms have been described.
Protein type: Nuclear receptor; DNA-binding
Chromosomal Location of Human Ortholog: 3p24.2
Cellular Component: nucleoplasm; nuclear chromatin; nucleus
Molecular Function: protein binding; enzyme binding; DNA binding; zinc ion binding; chromatin DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription corepressor activity; transcription factor activity
Biological Process: negative regulation of female receptivity; transcription initiation from RNA polymerase II promoter; organ morphogenesis; sensory perception of sound; female courtship behavior; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; negative regulation of transcription from RNA polymerase II promoter; regulation of heart contraction
Disease: Thyroid Hormone Resistance, Selective Pituitary; Thyroid Hormone Resistance, Generalized, Autosomal Dominant; Thyroid Hormone Resistance, Generalized, Autosomal Recessive
Research Articles on THRB
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-THRB antibody
Pathways associated with anti-THRB antibody
Diseases associated with anti-THRB antibody
Organs/Tissues associated with anti-THRB antibody
|