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anti-TICAM1 antibody :: Rabbit anti-Human TICAM1 / TRIF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240996
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TICAM1 / TRIF, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human TICAM1 / TRIF

 Product Synonym Names    Anti-TICAM1 / TRIF Antibody (C-Terminus) IHC-plus; TICAM1; IIAE6; TRIF; PRVTIRB; TICAM-1; Human TICAM1; TRIF
 Product Gene Name   

anti-TICAM1 antibody

[Similar Products]
 Product Synonym Gene Name    TRIF [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614850
 3D Structure    ModBase 3D Structure for Q8IUC6
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Peptide comprised of 14 amino acids from the C-terminus of human TICAM1
 Purity/Purification    Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human TICAM1 / TRIF.
 Immunogen Type    Synthetic peptide
 Immunogen    TICAM1 / TRIF antibody was raised against synthetic peptide from human TICAM1 / TRIF.
 Antigen Modification    C-Terminus
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 Preparation and Storage    Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-TICAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TICAM1 antibody

   TRIF is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TRIF, along with other molecules such as TIRP, TIRAP, and MyD88, serves as an adaptor protein to several of the TLR molecules.
 Applications Tested/Suitable for anti-TICAM1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-TICAM1 antibody    IHC-P (10 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-TICAM1 antibody    Anti-TICAM1 / TRIF antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-TICAM1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-TICAM1 antibody    Western blot of TRIF in human lung cell lysates with TRIF antibody at (A) 2 and (B) 4 g/ml.
anti-TICAM1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TICAM1. It may not necessarily be applicable to this product.
 NCBI GI #    41281981
 NCBI GeneID    148022
 NCBI Accession #    NP_891549.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_182919.3 [Other Products]
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 UniProt Primary Accession #    Q8IUC6 [Other Products]
 UniProt Secondary Accession #    O75532; Q86XP8; Q96GA0; B3Y691 [Other Products]
 UniProt Related Accession #    Q8IUC6 [Other Products]
 Molecular Weight    76,422 Da
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 NCBI Official Full Name    TIR domain-containing adapter molecule 1
 NCBI Official Synonym Full Names    toll-like receptor adaptor molecule 1
 NCBI Official Symbol    TICAM1 [Similar Products]
 NCBI Official Synonym Symbols   
TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1
[Similar Products]
 NCBI Protein Information    TIR domain-containing adapter molecule 1; putative NF-kappa-B-activating protein 502H; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter protein inducing IFN-beta; proline-rich, vinculin and TIR domain-containing protein B; toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
 UniProt Protein Name    TIR domain-containing adapter molecule 1
 UniProt Synonym Protein Names   
Proline-rich, vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; MyD88-3; TIR domain-containing adapter protein inducing IFN-beta
 Protein Family    TIR domain-containing adapter molecule
 UniProt Gene Name    TICAM1 [Similar Products]
 UniProt Synonym Gene Names    PRVTIRB; TRIF; TICAM-1; MyD88-3; TIR domain-containing adapter protein inducing IFN-beta [Similar Products]
 UniProt Entry Name    TCAM1_HUMAN
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 NCBI Summary for TICAM1    This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
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 UniProt Comments for TICAM1    TICAM1: an adaptor protein involved in innate immunity against invading pathogens. Associates with TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Interacts with the TIR domain of TLR3. Interacts with AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3. Interacts with TRAFD1.

Protein type: Apoptosis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: endosome membrane; cytosol

Molecular Function: protein binding; signal transducer activity; protein kinase binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of nitric oxide biosynthetic process; positive regulation of protein binding; MyD88-independent toll-like receptor signaling pathway; regulation of protein homodimerization activity; positive regulation of interleukin-6 production; toll-like receptor 3 signaling pathway; positive regulation of tumor necrosis factor production; positive regulation of natural killer cell activation; activation of NF-kappaB transcription factor; positive regulation of chemokine biosynthetic process; response to exogenous dsRNA; positive regulation of protein ubiquitination; positive regulation of interferon-beta biosynthetic process; macrophage activation during immune response; positive regulation of B cell proliferation; lipopolysaccharide-mediated signaling pathway; toll-like receptor signaling pathway; innate immune response; inflammatory response; defense response to virus; toll-like receptor 4 signaling pathway

Disease: Herpes Simplex Encephalitis, Susceptibility To, 4
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 Research Articles on TICAM1    1. PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TICAM1 antibodyPathways associated with anti-TICAM1 antibody
 Reference Product  PubMed Publications
 TLR3 antibody  >95 publications with TICAM1 and TLR3
 TLR4 antibody  >93 publications with TICAM1 and TLR4
 IRF3 antibody  >55 publications with TICAM1 and IRF3
 TLR2 antibody  >27 publications with TICAM1 and TLR2
 TBK1 antibody  >21 publications with TICAM1 and TBK1
 TICAM2 antibody  >20 publications with TICAM1 and TICAM2
 TRAF6 antibody  >18 publications with TICAM1 and TRAF6
 TRAF3 antibody  >5 publications with TICAM1 and TRAF3
 RIPK1 antibody  >4 publications with TICAM1 and RIPK1
 RIPK3 antibody  >3 publications with TICAM1 and RIPK3
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
Diseases associated with anti-TICAM1 antibodyOrgans/Tissues associated with anti-TICAM1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >32 publications with TICAM1 and Inflammation
 Necrosis Antibodies  >31 publications with TICAM1 and Necrosis
 Liver Diseases Antibodies  >10 publications with TICAM1 and Liver Diseases
 Kidney Diseases Antibodies  >4 publications with TICAM1 and Kidney Diseases
 Disease Models, Animal Antibodies  >3 publications with TICAM1 and Disease Models, Animal
 Lung Diseases Antibodies  >3 publications with TICAM1 and Lung Diseases
 Premature Birth Antibodies  >2 publications with TICAM1 and Premature Birth
 Adenocarcinoma Antibodies  >2 publications with TICAM1 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >1 publications with TICAM1 and Carcinoma, Hepatocellular
 Insulin Resistance Antibodies  >1 publications with TICAM1 and Insulin Resistance
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >36 publications with TICAM1 and Blood
 Bone Antibodies  >13 publications with TICAM1 and Bone
 Kidney Antibodies  >9 publications with TICAM1 and Kidney
 Vascular Antibodies  >6 publications with TICAM1 and Vascular
 Lung Antibodies  >5 publications with TICAM1 and Lung
 Intestine Antibodies  >4 publications with TICAM1 and Intestine
 Placenta Antibodies  >3 publications with TICAM1 and Placenta
 Heart Antibodies  >3 publications with TICAM1 and Heart
 Skin Antibodies  >2 publications with TICAM1 and Skin
 Embryonic Tissue Antibodies  >2 publications with TICAM1 and Embryonic Tissue
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