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anti-TICAM2 antibody :: Rabbit TICAM2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS5400155 anti-TICAM2 antibody
Unit / Price
0.1 mg FITC  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TICAM2, Polyclonal Antibody

 Also Known As   

TICAM2 Antibody FITC-Conjugated

 Product Synonym Names    Putative NF-kappa-B-activating protein 502; TICAM2; TIR containing adapter molecule 2; TIR domain-containing adapter molecule 2; TIRAP3; TIRP; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; TRAM; TRIF-related adapter molecule antibody
 Product Gene Name   

anti-TICAM2 antibody

[Similar Products]
 Matching Pairs    Antibody: TICAM2 (MBS5400155)
Positive Control: TICAM2 (MBS543348)
 Antibody/Peptide Pairs    TICAM2 peptide (MBS544609) is used for blocking the activity of TICAM2 antibody (MBS5400155)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608321
 3D Structure    ModBase 3D Structure for Q86XR7
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Form/Format    FITC-Conjugated
 Concentration    0.50-0.75 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide corresponding to unique amino acid sequences on TRIF-related adapter molecule.
 Expression    Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).
 Molecular Function    phospholipid binding, signal transducer activity
 Structure    Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs i
 Subcellular Location    Isoform 1 : Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic Reticulum. Early endosome membrane. Late endosome membrane, Isoform 2 : Endoplasmic Reticulum. Early endosome membrane. Late endosome membrane, Isoform 2 : Endoplasmic Reticulum. Early end
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-TICAM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TICAM2 antibody

   FITC-Conjugated TRIF-related adapter molecule Antibody
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
 Applications Tested/Suitable for anti-TICAM2 antibody   

Dot Blot (DB), ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TICAM2 antibody    Dot Blot: 1:20,000
ELISA: 1:20,000
Western Blot: 1:500-1:750
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NCBI/Uniprot data below describe general gene information for TICAM2. It may not necessarily be applicable to this product.
 NCBI GI #    29470173
 NCBI GeneID    353376
 NCBI Accession #    AAO74498.1 [Other Products]
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 UniProt Primary Accession #    Q86XR7 [Other Products]
 UniProt Secondary Accession #    Q6JUT2; B3Y698 [Other Products]
 UniProt Related Accession #    Q86XR7 [Other Products]
 Molecular Weight    46,173 Da
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 NCBI Official Full Name    TRIF-related adapter molecule
 NCBI Official Synonym Full Names    toll like receptor adaptor molecule 2
 NCBI Official Symbol    TICAM2 [Similar Products]
 NCBI Official Synonym Symbols   
TIRP; TRAM; TIRAP3; MyD88-4; TICAM-2
[Similar Products]
 NCBI Protein Information    TIR domain-containing adapter molecule 2
 UniProt Protein Name    TIR domain-containing adapter molecule 2
 UniProt Synonym Protein Names   
Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; MyD88-4
 Protein Family    TIR domain-containing adapter molecule
 UniProt Gene Name    TICAM2 [Similar Products]
 UniProt Synonym Gene Names    TIRAP3; TIRP; TRAM; TICAM-2; MyD88-4 [Similar Products]
 UniProt Entry Name    TCAM2_HUMAN
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 NCBI Summary for TICAM2    TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]
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 UniProt Comments for TICAM2    Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
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 Research Articles on TICAM2    1. Data show that Toll/IL-1R domain-containing adaptor molecule (TICAM)-2 possesses two conserved acidic amino acids, D91 and E92, which regulate TICAM-2 self-activation and signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TICAM2 antibodyPathways associated with anti-TICAM2 antibody
 Reference Product  PubMed Publications
 TLR4 antibody  >30 publications with TICAM2 and TLR4
 TICAM1 antibody  >24 publications with TICAM2 and TICAM1
 CD14 antibody  >11 publications with TICAM2 and CD14
 TRAF6 antibody  >7 publications with TICAM2 and TRAF6
 IL1B antibody  >4 publications with TICAM2 and IL1B
 LY96 antibody  >3 publications with TICAM2 and LY96
 IL1R1 antibody  >1 publications with TICAM2 and IL1R1
 IRAK4 antibody  >1 publications with TICAM2 and IRAK4
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Caspase Activation Via Extrinsic Apoptotic Signalig Pathway antibodies  Caspase Activation Via Extrinsic Apoptotic Signalig Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 IKK Complex Recruitment Mediated By RIP1 Pathway antibodies  IKK Complex Recruitment Mediated By RIP1 Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Ligand-dependent Caspase Activation Pathway antibodies  Ligand-dependent Caspase Activation Pathway Diagram
Diseases associated with anti-TICAM2 antibodyOrgans/Tissues associated with anti-TICAM2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >11 publications with TICAM2 and Inflammation
 Necrosis Antibodies  >7 publications with TICAM2 and Necrosis
 Atherosclerosis Antibodies  >2 publications with TICAM2 and Atherosclerosis
 Drug-Induced Liver Injury Antibodies  >1 publications with TICAM2 and Drug-Induced Liver Injury
 Kidney Diseases Antibodies  >1 publications with TICAM2 and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with TICAM2 and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with TICAM2 and Cell Transformation, Neoplastic
 Heart Diseases Antibodies  >1 publications with TICAM2 and Heart Diseases
 Liver Diseases Antibodies  >1 publications with TICAM2 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with TICAM2 and Blood
 Bone Antibodies  >3 publications with TICAM2 and Bone
 Bone Marrow Antibodies  >3 publications with TICAM2 and Bone Marrow
 Liver Antibodies  >3 publications with TICAM2 and Liver
 Brain Antibodies  >3 publications with TICAM2 and Brain
 Kidney Antibodies  >2 publications with TICAM2 and Kidney
 Heart Antibodies  >2 publications with TICAM2 and Heart
 Vascular Antibodies  >2 publications with TICAM2 and Vascular
 Muscle Antibodies  >2 publications with TICAM2 and Muscle
 Thymus Antibodies  >1 publications with TICAM2 and Thymus
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