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anti-TICAM2 antibody :: Rabbit TICAM2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS540667
Western Blot (WB)
Unit / Price
0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TICAM2, Polyclonal Antibody

 Also Known As   

TICAM2 Antibody Affinity Purified

 Product Synonym Names    Putative NF-kappa-B-activating protein 502; TICAM2; TIR containing adapter molecule 2; TIR domain containing adaptor protein; TIR domain-containing adapter molecule 2; TIRAP3; TIRP; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; TRAM; TRIF-related adapter molecule antibody
 Product Gene Name   

anti-TICAM2 antibody

[Similar Products]
 Matching Pairs    Antibody: TICAM2 (MBS540667)
Positive Control: TICAM2 (MBS543313)
 Antibody/Peptide Pairs    TICAM2 peptide (MBS544569) is used for blocking the activity of TICAM2 antibody (MBS540667)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608321
 3D Structure    ModBase 3D Structure for Q86XR7
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Cat, Human, Monkey, Pig
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 Form/Format    Affinity Purified
 Concentration    0.60-0.65 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide taken within amino acid region 140-170 on human TIRAP3b long form protein.
 Expression    Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).
 Molecular Function    Phospholipid binding, signal transducer activity
 Structure    Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs i
 Subcellular Location    Isoform 1: Cytoplasm, Golgi apparatus, Cell membrane, Endoplasmic Reticulum, Early endosome membrane, Late endosome membrane. Isoform 2: Endoplasmic Reticulum, Early endosome membrane, Late endosome membrane
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-TICAM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TICAM2 antibody

   Affinity Purified TIRAP3b long form Antibody
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4.
 Product Categories/Family for anti-TICAM2 antibody    Primary Antibodies; TICAM2 Antibody
 Applications Tested/Suitable for anti-TICAM2 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TICAM2 antibody    Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:250
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 Western Blot (WB) of anti-TICAM2 antibody    anti-TICAM2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TICAM2. It may not necessarily be applicable to this product.
 NCBI GI #    37677661
 NCBI GeneID    100302736
 NCBI Accession #    AAQ97430.1 [Other Products]
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 UniProt Primary Accession #    Q86XR7 [Other Products]
 UniProt Secondary Accession #    Q6JUT2; B3Y698 [Other Products]
 Molecular Weight    46,173 Da
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 NCBI Official Full Name    TIRAP3b long form
 NCBI Official Synonym Full Names    TMED7-TICAM2 readthrough
 NCBI Official Symbol    TMED7-TICAM2 [Similar Products]
 NCBI Protein Information    TRAM adaptor with GOLD domain
 UniProt Protein Name    TIR domain-containing adapter molecule 2
 UniProt Synonym Protein Names   
Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; MyD88-4
 Protein Family    TIR domain-containing adapter molecule
 UniProt Gene Name    TICAM2 [Similar Products]
 UniProt Synonym Gene Names    TIRAP3; TIRP; TRAM; TICAM-2; MyD88-4 [Similar Products]
 UniProt Entry Name    TCAM2_HUMAN
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 NCBI Summary for TICAM2    This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]
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 UniProt Comments for TICAM2    Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TICAM2 antibodyDiseases associated with anti-TICAM2 antibody
 Products by Pathway  Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram
 Toll-like Receptor Signaling Pathway antibodies  Toll-like Receptor Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >1 publications with TICAM2 and Cell Transformation, Neoplastic
Organs/Tissues associated with anti-TICAM2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with TICAM2 and Blood
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