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anti-TIE2 antibody :: Rabbit anti-Human TIE2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9406636
Western Blot (WB)
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TIE2, Polyclonal Antibody

★Popular Item★
 Also Known As   

TIE2 (Phospho-Tyr992) Antibody

 Product Synonym Names    Angiopoietin-1 receptor,EC=2.7.10.1 Tunica interna endothelial cell kinase Tyrosine-protein kinase receptor TEK Tyrosine-protein kinase receptor TIE-2 hTIE2 p140 TEK CD202b TEK TIE2
 Product Gene Name   

anti-TIE2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600195
 3D Structure    ModBase 3D Structure for Q02763
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The Antibody detects endogenous levels of TIE2 only when phosphorylated at Tyr992.
 Purity/Purification    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Peptide-KLH
 Immunogen Description    Peptide sequence around phosphorylation site of tyrosine 992 (E-V-Y(p)-V-K) derived from Human TIE2.
 Modification    Phospho-Tyr992
 Target Name    TIE2
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-TIE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TIE2 antibody

   The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.Schooley K.A., Baum P.R. Oncogene 8:663-670(1993)Dunham I. Nature 429:369-374(2004)Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
 Product Categories/Family for anti-TIE2 antibody    Phospho-specific Ab
 Applications Tested/Suitable for anti-TIE2 antibody   

Western Blot (WB)

 Application Notes for anti-TIE2 antibody    Western blotting: 1:500~1:1000
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 Western Blot (WB) of anti-TIE2 antibody    Western blot analysis of extracts from HepG2 using TIE2 (Phospho-Tyr992) Antibody.The lane on the right is treated with the antigen-specific peptide.
anti-TIE2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TIE2. It may not necessarily be applicable to this product.
 NCBI GI #    88758596
 NCBI GeneID    7010
 NCBI Accession #    NP_000450.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000459.4 [Other Products]
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 UniProt Primary Accession #    Q02763 [Other Products]
 UniProt Secondary Accession #    Q5TCU2; Q8IV34; A8K6W0; B4DH20; B4DHD3; D3DRK5; E7EWI2 [Other Products]
 UniProt Related Accession #    Q02763 [Other Products]
 Molecular Weight    109,141 Da
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 NCBI Official Full Name    angiopoietin-1 receptor isoform 1
 NCBI Official Synonym Full Names    TEK tyrosine kinase, endothelial
 NCBI Official Symbol    TEK [Similar Products]
 NCBI Official Synonym Symbols   
TIE2; VMCM; TIE-2; VMCM1; CD202B
[Similar Products]
 NCBI Protein Information    angiopoietin-1 receptor
 UniProt Protein Name    Angiopoietin-1 receptor
 UniProt Synonym Protein Names   
Endothelial tyrosine kinase; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; hTIE2; p140 TEK; CD_antigen: CD202b
 Protein Family    Tyrosine-protein kinase receptor
 UniProt Gene Name    TEK [Similar Products]
 UniProt Synonym Gene Names    TIE2; VMCM; VMCM1; hTIE2 [Similar Products]
 UniProt Entry Name    TIE2_HUMAN
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 NCBI Summary for TIE2    This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
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 UniProt Comments for TIE2    TIE2: a receptor tyrosine kinase of the Tie family. Receptor for angiopoietin 1. Expressed almost exclusively in endothelial cells. May constitute the earliest mammalian endothelial cell lineage marker. Appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.

Protein type: Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Membrane protein, integral; TK group; Tie family

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: microvillus; focal adhesion; cell surface; basolateral plasma membrane; integral to plasma membrane; extracellular region; actin filament; intercellular junction; lipid raft; perinuclear region of cytoplasm; apical plasma membrane; stress fiber; basal plasma membrane; plasma membrane

Molecular Function: protein binding; protein-tyrosine kinase activity; growth factor binding; transmembrane receptor protein tyrosine kinase activity; receptor activity; ATP binding; protein kinase activity

Biological Process: response to peptide hormone stimulus; peptidyl-tyrosine phosphorylation; response to cAMP; protein amino acid autophosphorylation; cell-matrix adhesion; heart development; positive regulation of cytokine secretion during immune response; signal transduction; cell-cell adhesion; cell-cell signaling; positive regulation of focal adhesion formation; angiogenesis; endochondral ossification; Tie receptor signaling pathway; organ regeneration; regulation of establishment and/or maintenance of cell polarity; positive regulation of phosphoinositide 3-kinase activity; positive regulation of peptidyl-serine phosphorylation; protein oligomerization; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; negative regulation of angiogenesis; positive regulation of protein import into nucleus; response to estrogen stimulus; endothelial cell proliferation; negative regulation of inflammatory response; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; positive regulation of protein amino acid phosphorylation; regulation of vascular permeability; blood coagulation; leukocyte migration; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis

Disease: Venous Malformations, Multiple Cutaneous And Mucosal
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 Research Articles on TIE2    1. TIE-2 levels were changed at the organ level in lethal sepsis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TIE2 antibodyPathways associated with anti-TIE2 antibody
 Reference Product  PubMed Publications
 ANGPT2 antibody  >49 publications with TIE2 and ANGPT2
 ANGPT1 antibody  >41 publications with TIE2 and ANGPT1
 GRB14 antibody  >3 publications with TIE2 and GRB14
 DOK2 antibody  >3 publications with TIE2 and DOK2
 GRB2 antibody  >2 publications with TIE2 and GRB2
 PTPN11 antibody  >2 publications with TIE2 and PTPN11
 SHC1 antibody  >1 publications with TIE2 and SHC1
 ANGPT4 antibody  >1 publications with TIE2 and ANGPT4
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
Diseases associated with anti-TIE2 antibodyOrgans/Tissues associated with anti-TIE2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >66 publications with TIE2 and Cardiovascular Diseases
 Neovascularization, Pathologic Antibodies  >56 publications with TIE2 and Neovascularization, Pathologic
 Inflammation Antibodies  >51 publications with TIE2 and Inflammation
 Neoplasms, Experimental Antibodies  >23 publications with TIE2 and Neoplasms, Experimental
 Heart Diseases Antibodies  >22 publications with TIE2 and Heart Diseases
 Hypertension Antibodies  >17 publications with TIE2 and Hypertension
 Liver Diseases Antibodies  >16 publications with TIE2 and Liver Diseases
 Necrosis Antibodies  >16 publications with TIE2 and Necrosis
 Lung Neoplasms Antibodies  >15 publications with TIE2 and Lung Neoplasms
 Kidney Diseases Antibodies  >12 publications with TIE2 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >232 publications with TIE2 and Vascular
 Muscle Antibodies  >66 publications with TIE2 and Muscle
 Embryonic Tissue Antibodies  >64 publications with TIE2 and Embryonic Tissue
 Lung Antibodies  >58 publications with TIE2 and Lung
 Brain Antibodies  >40 publications with TIE2 and Brain
 Kidney Antibodies  >29 publications with TIE2 and Kidney
 Mouth Antibodies  >11 publications with TIE2 and Mouth
 Uterus Antibodies  >10 publications with TIE2 and Uterus
 Bladder Antibodies  >9 publications with TIE2 and Bladder
 Placenta Antibodies  >9 publications with TIE2 and Placenta
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