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anti-TIMP-2 antibody :: Rabbit TIMP-2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2536441
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TIMP-2, Polyclonal Antibody

★Popular Item★
 Also Known As   

TIMP-2 Polyclonal Antibody

 Product Synonym Names    TIMP2; Metalloproteinase inhibitor 2; CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2
 Product Gene Name   

anti-TIMP-2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    188825
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the Internal region of human TIMP-2.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TIMP-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-TIMP-2 antibody    Cancer; Cell biology; Epigenetics
 Applications Tested/Suitable for anti-TIMP-2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-TIMP-2 antibody    WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-TIMP-2 antibody    Western Blot analysis of various cells using TIMP-2 Polyclonal Antibody at dilution of 1:1000.
anti-TIMP-2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TIMP-2 antibody    Immunohistochemistry of paraffin-embedded Mouse kidney using TIMP-2 antibody at dilution of 1:200
anti-TIMP-2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TIMP-2. It may not necessarily be applicable to this product.
 NCBI GI #    298202
 NCBI GeneID    7077
 NCBI Accession #    AAB19474.1 [Other Products]
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 UniProt Secondary Accession #    Q16121; Q93006; Q9UDF7 [Other Products]
 UniProt Related Accession #    P16035 [Other Products]
 Molecular Weight    Calculated MW: 24
Observed MW: 30
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 NCBI Official Full Name    tissue inhibitor of metalloproteinase 2
 NCBI Official Synonym Full Names    TIMP metallopeptidase inhibitor 2
 NCBI Official Symbol    TIMP2 [Similar Products]
 NCBI Official Synonym Symbols   
DDC8; CSC-21K
[Similar Products]
 NCBI Protein Information    metalloproteinase inhibitor 2
 UniProt Protein Name    Metalloproteinase inhibitor 2
 UniProt Synonym Protein Names   
CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2
 UniProt Gene Name    TIMP2 [Similar Products]
 UniProt Synonym Gene Names    TIMP-2 [Similar Products]
 UniProt Entry Name    TIMP2_HUMAN
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 NCBI Summary for TIMP-2    This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TIMP-2    TIMP2: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Interacts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. Down-regulated by TGFB1. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Secreted; Secreted, signal peptide; Cell development/differentiation; Inhibitor; Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: basement membrane; cell soma; cell surface; extracellular region; extracellular space; growth cone; proteinaceous extracellular matrix

Molecular Function: enzyme activator activity; integrin binding; metal ion binding; metalloendopeptidase inhibitor activity; protease binding; protein binding

Biological Process: aging; central nervous system development; extracellular matrix disassembly; extracellular matrix organization and biogenesis; negative regulation of cell proliferation; negative regulation of membrane protein ectodomain proteolysis; negative regulation of metalloenzyme activity; negative regulation of mitotic cell cycle; negative regulation of Ras protein signal transduction; positive regulation of adenylate cyclase activity; positive regulation of MAPKKK cascade; positive regulation of neuron differentiation; regulation of Rap protein signal transduction; response to cytokine stimulus; response to drug; response to hormone stimulus
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 Research Articles on TIMP-2    1. Upregulation of EZH2, MMP2 and TIMP2 expression was correlated with metastasis of RCC to bone tissues ex vivo and in vitro.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TIMP-2 antibodyPathways associated with anti-TIMP-2 antibody
 Reference Product  PubMed Publications
 MMP2 antibody  >349 publications with TIMP-2 and MMP2
 MMP9 antibody  >211 publications with TIMP-2 and MMP9
 MMP14 antibody  >50 publications with TIMP-2 and MMP14
 MMP13 antibody  >31 publications with TIMP-2 and MMP13
 MMP8 antibody  >15 publications with TIMP-2 and MMP8
 MMP10 antibody  >14 publications with TIMP-2 and MMP10
 RECK antibody  >8 publications with TIMP-2 and RECK
 MMP16 antibody  >3 publications with TIMP-2 and MMP16
 FURIN antibody  >2 publications with TIMP-2 and FURIN
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
Diseases associated with anti-TIMP-2 antibodyOrgans/Tissues associated with anti-TIMP-2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >96 publications with TIMP-2 and Cardiovascular Diseases
 Neoplasm Metastasis Antibodies  >79 publications with TIMP-2 and Neoplasm Metastasis
 Neoplasm Invasiveness Antibodies  >77 publications with TIMP-2 and Neoplasm Invasiveness
 Fibrosis Antibodies  >69 publications with TIMP-2 and Fibrosis
 Inflammation Antibodies  >63 publications with TIMP-2 and Inflammation
 Heart Diseases Antibodies  >51 publications with TIMP-2 and Heart Diseases
 Disease Models, Animal Antibodies  >45 publications with TIMP-2 and Disease Models, Animal
 Liver Diseases Antibodies  >36 publications with TIMP-2 and Liver Diseases
 Kidney Diseases Antibodies  >34 publications with TIMP-2 and Kidney Diseases
 Necrosis Antibodies  >33 publications with TIMP-2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >160 publications with TIMP-2 and Blood
 Vascular Antibodies  >111 publications with TIMP-2 and Vascular
 Muscle Antibodies  >56 publications with TIMP-2 and Muscle
 Bone Antibodies  >54 publications with TIMP-2 and Bone
 Embryonic Tissue Antibodies  >54 publications with TIMP-2 and Embryonic Tissue
 Kidney Antibodies  >53 publications with TIMP-2 and Kidney
 Liver Antibodies  >52 publications with TIMP-2 and Liver
 Lung Antibodies  >51 publications with TIMP-2 and Lung
 Heart Antibodies  >47 publications with TIMP-2 and Heart
 Placenta Antibodies  >33 publications with TIMP-2 and Placenta
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