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anti-TIMP1 antibody :: Rabbit TIMP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2516667
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TIMP1, Polyclonal Antibody

★Popular Item★
 Also Known As   

TIMP1 Polyclonal Antibody

 Product Synonym Names    EPA; EPO; HCI; CLGI; TIMP
 Product Gene Name   

anti-TIMP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q6FGX5
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    0.5mg/mL (lot specific)
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 Immunogen    Recombinant protein of human TIMP1
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TIMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TIMP1 antibody

   This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
 Product Categories/Family for anti-TIMP1 antibody    Cancer; Cell biology; Epigenetics
 Applications Tested/Suitable for anti-TIMP1 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-TIMP1 antibody    IHC: 1:15-1:50
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 Immunohistochemistry (IHC) of anti-TIMP1 antibody    Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TIMP1 Polyclonal Antibody at dilution 1:15
anti-TIMP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TIMP1 antibody    Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TIMP1 Polyclonal Antibody at dilution 1:15
anti-TIMP1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TIMP1. It may not necessarily be applicable to this product.
 NCBI GI #    49456917
 NCBI GeneID    7076
 NCBI Accession #    CAG46779.1 [Other Products]
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 UniProt Primary Accession #    Q6FGX5 [Other Products]
 UniProt Related Accession #    P01033 [Other Products]
 Molecular Weight    23,171 Da
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 NCBI Official Full Name    TIMP1
 NCBI Official Synonym Full Names    TIMP metallopeptidase inhibitor 1
 NCBI Official Symbol    TIMP1 [Similar Products]
 NCBI Official Synonym Symbols   
EPA; EPO; HCI; CLGI; TIMP
[Similar Products]
 NCBI Protein Information    metalloproteinase inhibitor 1; TIMP-1; collagenase inhibitor; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1
 UniProt Protein Name    TIMP metallopeptidase inhibitor 1, isoform CRA_a
 UniProt Synonym Protein Names   
TIMP metallopeptidase inhibitor 1, isoform CRA_a
 Protein Family    Metalloproteinase inhibitor
 UniProt Gene Name    TIMP1 [Similar Products]
 UniProt Entry Name    Q6FGX5_HUMAN
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 NCBI Summary for TIMP1    This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TIMP1    TIMP1: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xp11.3-p11.23

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region; basement membrane

Molecular Function: metalloendopeptidase inhibitor activity; protein binding; protease binding; growth factor activity; metal ion binding; cytokine activity

Biological Process: response to peptide hormone stimulus; platelet activation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; negative regulation of metalloenzyme activity; platelet degranulation; response to cytokine stimulus; positive regulation of cell proliferation; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis; blood coagulation; aging; negative regulation of apoptosis
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 Research Articles on TIMP1    1. We found no valuable cut-offs for the TIMP1 and TIMP1/Cr values in hydronephrosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TIMP1 antibodyDiseases associated with anti-TIMP1 antibody
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >166 publications with TIMP1 and Fibrosis
 Inflammation Antibodies  >149 publications with TIMP1 and Inflammation
 Cardiovascular Diseases Antibodies  >142 publications with TIMP1 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >106 publications with TIMP1 and Vascular Diseases
 Disease Models, Animal Antibodies  >100 publications with TIMP1 and Disease Models, Animal
 Liver Diseases Antibodies  >92 publications with TIMP1 and Liver Diseases
 Necrosis Antibodies  >86 publications with TIMP1 and Necrosis
 Heart Diseases Antibodies  >73 publications with TIMP1 and Heart Diseases
 Female Urogenital Diseases Antibodies  >64 publications with TIMP1 and Female Urogenital Diseases
 Liver Cirrhosis Antibodies  >59 publications with TIMP1 and Liver Cirrhosis
Organs/Tissues associated with anti-TIMP1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >277 publications with TIMP1 and Blood
 Vascular Antibodies  >131 publications with TIMP1 and Vascular
 Liver Antibodies  >121 publications with TIMP1 and Liver
 Muscle Antibodies  >110 publications with TIMP1 and Muscle
 Lung Antibodies  >97 publications with TIMP1 and Lung
 Bone Antibodies  >81 publications with TIMP1 and Bone
 Heart Antibodies  >80 publications with TIMP1 and Heart
 Connective Tissue Antibodies  >65 publications with TIMP1 and Connective Tissue
 Kidney Antibodies  >61 publications with TIMP1 and Kidney
 Embryonic Tissue Antibodies  >58 publications with TIMP1 and Embryonic Tissue
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