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anti-TIMP3 antibody :: Rabbit TIMP3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2524959
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TIMP3, Polyclonal Antibody

★Popular Item★
 Also Known As   

TIMP3 Polyclonal Antibody

 Product Synonym Names    SFD; K222; K222TA2; HSMRK222
 Product Gene Name   

anti-TIMP3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    136900
 3D Structure    ModBase 3D Structure for P35625
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    0.5mg/mL (lot specific)
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 Immunogen    Recombinant protein of human TIMP3
 Calculated Molecular Weight: 24kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TIMP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TIMP3 antibody

   This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
 Product Categories/Family for anti-TIMP3 antibody    Cancer; Cell biology; Epigenetics
 Applications Tested/Suitable for anti-TIMP3 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TIMP3 antibody    WB: 1:200-1:1000
IHC: 1:15-1:50
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 Western Blot (WB) of anti-TIMP3 antibody    Western Blot analysis of Huvec cell using TIMP3 Polyclonal Antibody at dilution of 1:250
anti-TIMP3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TIMP3 antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer using TIMP3 Polyclonal Antibody at dilution of 1:20
anti-TIMP3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TIMP3 antibody    Immunohistochemistry of paraffin-embedded Human cervical cancer using TIMP3 Polyclonal Antibody at dilution of 1:20
anti-TIMP3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TIMP3. It may not necessarily be applicable to this product.
 NCBI GI #    47678717
 NCBI GeneID    7078
 NCBI Accession #    CAG30479.1 [Other Products]
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 UniProt Primary Accession #    P35625 [Other Products]
 UniProt Secondary Accession #    Q5THV4; Q9UC74; Q9UGS2; B2RBY9 [Other Products]
 UniProt Related Accession #    P35625 [Other Products]
 Molecular Weight    24,145 Da
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 NCBI Official Full Name    TIMP3
 NCBI Official Synonym Full Names    TIMP metallopeptidase inhibitor 3
 NCBI Official Symbol    TIMP3 [Similar Products]
 NCBI Official Synonym Symbols   
SFD; K222; K222TA2; HSMRK222
[Similar Products]
 NCBI Protein Information    metalloproteinase inhibitor 3; MIG-5 protein; TIMP-3; protein MIG-5; tissue inhibitor of metalloproteinases 3
 UniProt Protein Name    Metalloproteinase inhibitor 3
 UniProt Synonym Protein Names   
Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3
 Protein Family    Metalloproteinase inhibitor
 UniProt Gene Name    TIMP3 [Similar Products]
 UniProt Synonym Gene Names    TIMP-3 [Similar Products]
 UniProt Entry Name    TIMP3_HUMAN
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 NCBI Summary for TIMP3    This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TIMP3    TIMP3: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Interacts with EFEMP1. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; basement membrane; nucleus

Molecular Function: metalloendopeptidase inhibitor activity; protein binding; protease binding; metal ion binding

Biological Process: negative regulation of metalloenzyme activity; visual perception; response to cytokine stimulus; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis

Disease: Fundus Dystrophy, Pseudoinflammatory, Of Sorsby
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 Research Articles on TIMP3    1. Data show that gene polymorphisms of TIMP metallopeptidase inhibitors TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) were associated with the susceptibility of hepatocellular carcinoma among Taiwan women.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TIMP3 antibodyPathways associated with anti-TIMP3 antibody
 Reference Product  PubMed Publications
 MMP2 antibody  >74 publications with TIMP3 and MMP2
 MMP9 antibody  >65 publications with TIMP3 and MMP9
 GSTP1 antibody  >52 publications with TIMP3 and GSTP1
 MMP3 antibody  >37 publications with TIMP3 and MMP3
 ADAM17 antibody  >21 publications with TIMP3 and ADAM17
 TGFB1 antibody  >19 publications with TIMP3 and TGFB1
 EFEMP1 antibody  >9 publications with TIMP3 and EFEMP1
 TP53 antibody  >8 publications with TIMP3 and TP53
 OSM antibody  >2 publications with TIMP3 and OSM
 Products by Pathway  Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Oncostatin M Signaling Pathway antibodies  Oncostatin M Signaling Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
Diseases associated with anti-TIMP3 antibodyOrgans/Tissues associated with anti-TIMP3 antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >73 publications with TIMP3 and Adenocarcinoma
 Necrosis Antibodies  >64 publications with TIMP3 and Necrosis
 Inflammation Antibodies  >60 publications with TIMP3 and Inflammation
 Cardiovascular Diseases Antibodies  >50 publications with TIMP3 and Cardiovascular Diseases
 Neoplasm Metastasis Antibodies  >46 publications with TIMP3 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >37 publications with TIMP3 and Disease Models, Animal
 Breast Neoplasms Antibodies  >36 publications with TIMP3 and Breast Neoplasms
 Liver Diseases Antibodies  >31 publications with TIMP3 and Liver Diseases
 Neoplasms, Experimental Antibodies  >29 publications with TIMP3 and Neoplasms, Experimental
 Heart Diseases Antibodies  >26 publications with TIMP3 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >74 publications with TIMP3 and Blood
 Vascular Antibodies  >74 publications with TIMP3 and Vascular
 Eye Antibodies  >71 publications with TIMP3 and Eye
 Liver Antibodies  >46 publications with TIMP3 and Liver
 Lung Antibodies  >42 publications with TIMP3 and Lung
 Muscle Antibodies  >34 publications with TIMP3 and Muscle
 Brain Antibodies  >30 publications with TIMP3 and Brain
 Heart Antibodies  >29 publications with TIMP3 and Heart
 Embryonic Tissue Antibodies  >29 publications with TIMP3 and Embryonic Tissue
 Bone Antibodies  >27 publications with TIMP3 and Bone
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