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anti-M6PRBP1 antibody :: Rabbit anti-Human, Rat TIP47 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151454
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TIP47 (M6PRBP1), Polyclonal Antibody

 Also Known As   

TIP47 Antibody

 Product Synonym Names    TIP47; PP17; TIP47; M6PRBP1; Perilipin-3; 47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; mannose-6-phosphate receptor binding protein 1
 Product Gene Name   

anti-M6PRBP1 antibody

[Similar Products]
 Antibody/Peptide Pairs    TIP47 peptide (MBS152707) is used for blocking the activity of TIP47 antibody (MBS151454)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602702
 3D Structure    ModBase 3D Structure for O60664
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Purity/Purification    TIP47 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    TIP47 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human TIP47.
 Buffer    TIP47 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    TIP47 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-M6PRBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-M6PRBP1 antibody

   TIP47 Antibody: Tail-interacting protein (TIP47) is a cytosolic protein essential for the transport of mannose-6-phosphate receptors (MPRs) from endosomes to the trans-Golgi compartments in cells. TIP47 is recruited from the cytoplasm to the late endosomal surface by the Ras-associated protein Rab9 GTPase, enabling it to bind more efficiently to MPR cytoplasmic domains. Recently, it was shown that TIP47 regulates the expression of Rab9, as expression of siRNA to TIP47 in transfected cells dramatically decreased the half-life of the Rab9 protein in addition to stabilizing the subcellular localization of Rab9. At least two isoforms of TIP47 are known to exist.
 Applications Tested/Suitable for anti-M6PRBP1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-M6PRBP1 antibody    TIP47 antibody can be used for the detection of TIP47 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-M6PRBP1 antibody    Western blot analysis of TIP47 in Daudi cell lysate with TIP47 antibody at (A) 0.5 and (B) 1 μg/mL.
anti-M6PRBP1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-M6PRBP1 antibody    Immunohistochemistry of TIP47 in rat liver tissue with TIP47 antibody at 10 μg/mL.
anti-M6PRBP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-M6PRBP1 antibody    Immunofluorescence of TIP47 in Rat Liver cells with TIP47 antibody at 20 μg/mL.
anti-M6PRBP1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for M6PRBP1. It may not necessarily be applicable to this product.
 NCBI GI #    68846601
 NCBI GeneID    10226
 NCBI Accession #    O60664.2 [Other Products]
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 UniProt Primary Accession #    O60664 [Other Products]
 UniProt Secondary Accession #    Q53G77; Q9BS03; Q9UBD7; Q9UP92; A8K4Y9; K7EQF4 [Other Products]
 UniProt Related Accession #    O60664 [Other Products]
 Molecular Weight    45,803 Da
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 NCBI Official Full Name    Perilipin-3
 NCBI Official Synonym Full Names    perilipin 3
 NCBI Official Symbol    PLIN3 [Similar Products]
 NCBI Official Synonym Symbols   
PP17; TIP47; M6PRBP1
[Similar Products]
 NCBI Protein Information    perilipin-3; placental protein 17; 47 kDa MPR-binding protein; cargo selection protein TIP47; tail-interacting protein, 47 kD; mannose-6-phosphate receptor-binding protein 1
 UniProt Protein Name    Perilipin-3
 UniProt Synonym Protein Names   
47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; Cargo selection protein TIP47; Mannose-6-phosphate receptor-binding protein 1; Placental protein 17; PP17
 UniProt Gene Name    PLIN3 [Similar Products]
 UniProt Synonym Gene Names    M6PRBP1; TIP47; 47 kDa MPR-binding protein; PP17 [Similar Products]
 UniProt Entry Name    PLIN3_HUMAN
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 NCBI Summary for M6PRBP1    Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]
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 UniProt Comments for M6PRBP1    perilipin 3: a membrane-associated protein and a coat protein for lipid droplets (LDs). It has been described as a mannose-6-phosphate receptor (MPR) binding protein required for endosome-to-Golgi transport of MPRs, but this function has been disputed. Interacts with M6PR and IGF2R via their cytoplasmic domains. Affects hepatic lipid and glucose metabolism. Belongs to the perilipin family. 3 isoforms of the human protein are produced by alternative splicing. Isoform 2 may exist as a homodimer known as PP17C.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; membrane; cytoplasm; endosome membrane; lipid particle; endosome

Molecular Function: protein binding

Biological Process: vesicle-mediated transport
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 Research Articles on M6PRBP1    1. Skeletal muscle perilipin 3 and coatomer proteins are increased following exercise and are associated with fat oxidation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-M6PRBP1 antibodyDiseases associated with anti-M6PRBP1 antibody
 Reference Product  PubMed Publications
 M6PR antibody  >16 publications with M6PRBP1 and M6PR
 IGF2R antibody  >16 publications with M6PRBP1 and IGF2R
 RAB9A antibody  >7 publications with M6PRBP1 and RAB9A
 RHOBTB3 antibody  >1 publications with M6PRBP1 and RHOBTB3
 SPG20 antibody  >1 publications with M6PRBP1 and SPG20
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >10 publications with M6PRBP1 and Liver Diseases
 Carcinoma Antibodies  >10 publications with M6PRBP1 and Carcinoma
 Fatty Liver Antibodies  >10 publications with M6PRBP1 and Fatty Liver
 Uterine Cervical Neoplasms Antibodies  >5 publications with M6PRBP1 and Uterine Cervical Neoplasms
 Kidney Diseases Antibodies  >4 publications with M6PRBP1 and Kidney Diseases
 Carcinoma, Squamous Cell Antibodies  >3 publications with M6PRBP1 and Carcinoma, Squamous Cell
 Inflammation Antibodies  >2 publications with M6PRBP1 and Inflammation
 Liver Neoplasms Antibodies  >2 publications with M6PRBP1 and Liver Neoplasms
 Liver Cirrhosis Antibodies  >1 publications with M6PRBP1 and Liver Cirrhosis
 Proteinuria Antibodies  >1 publications with M6PRBP1 and Proteinuria
Organs/Tissues associated with anti-M6PRBP1 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >18 publications with M6PRBP1 and Muscle
 Liver Antibodies  >14 publications with M6PRBP1 and Liver
 Blood Antibodies  >13 publications with M6PRBP1 and Blood
 Connective Tissue Antibodies  >8 publications with M6PRBP1 and Connective Tissue
 Bone Antibodies  >6 publications with M6PRBP1 and Bone
 Kidney Antibodies  >5 publications with M6PRBP1 and Kidney
 Placenta Antibodies  >5 publications with M6PRBP1 and Placenta
 Embryonic Tissue Antibodies  >4 publications with M6PRBP1 and Embryonic Tissue
 Heart Antibodies  >3 publications with M6PRBP1 and Heart
 Cervix Antibodies  >3 publications with M6PRBP1 and Cervix
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