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anti-TICAM2 antibody :: Rabbit TIRP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150354
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TIRP (TICAM2), Polyclonal Antibody

 Also Known As   

TIRP Antibody

 Product Synonym Names    TIRP; TIRP; TRAM; TIRAP3; MyD88-4; TICAM-2; TIRP; TIR domain-containing adapter molecule 2; Putative NF-kappa-B-activating protein 502; toll-like receptor adaptor molecule 2
 Product Gene Name   

anti-TICAM2 antibody

[Similar Products]
 Antibody/Peptide Pairs    TIRP peptide (MBS152317) is used for blocking the activity of TIRP antibody (MBS150354)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608321
 3D Structure    ModBase 3D Structure for Q86XR7
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    TIRP Antibody is Ion exchange chromatography purified.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    TIRP antibody was raised against a peptide corresponding to amino acids near the C-terminus of human TIRP.
 Buffer    TIRP Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    TIRP antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-TICAM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TICAM2 antibody

   TIRP Antibody: TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-κB. Expression of TIRP appears to be essential for TLR4 signalling.
 Applications Tested/Suitable for anti-TICAM2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-TICAM2 antibody    TIRP antibody can be used for detection of TIRP by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-TICAM2 antibody    Western blot analysis of TIRP in human (A), mouse (B), and rat (C) kidney cell lysates with TIRP antibody (C2) at 1 μg/mL.
anti-TICAM2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TICAM2 antibody    Immunohistochemical staining of mouse kidney using TIRP antibody at 2 μg/mL.
anti-TICAM2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-TICAM2 antibody    Immunofluorescence of TIRP in Mouse Kidney cells with TIRP antibody at 20 μg/mL.
anti-TICAM2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for TICAM2. It may not necessarily be applicable to this product.
 NCBI GI #    32435943
 NCBI GeneID    100302736
 NCBI Accession #    AAP81748 [Other Products]
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 UniProt Primary Accession #    Q86XR7 [Other Products]
 UniProt Secondary Accession #    Q6JUT2; B3Y698 [Other Products]
 Molecular Weight    46,173 Da
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 NCBI Official Full Name    TIR domain-containing adapter protein
 NCBI Official Synonym Full Names    TMED7-TICAM2 readthrough
 NCBI Official Symbol    TMED7-TICAM2 [Similar Products]
 NCBI Protein Information    TRAM adaptor with GOLD domain; TMED7-TICAM2 read-through transcript
 UniProt Protein Name    TIR domain-containing adapter molecule 2
 UniProt Synonym Protein Names   
Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; MyD88-4
 Protein Family    TIR domain-containing adapter molecule
 UniProt Gene Name    TICAM2 [Similar Products]
 UniProt Synonym Gene Names    TIRAP3; TIRP; TRAM; TICAM-2; MyD88-4 [Similar Products]
 UniProt Entry Name    TCAM2_HUMAN
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 NCBI Summary for TICAM2    This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]
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 UniProt Comments for TICAM2    TICAM2: a toll-like receptor adapter that participates in induction of type 1 interferons. Transiently phosphorylated on serine-16 during LPS/Toll-like receptor 4 (TLR4) signaling. Activated TLR4 associates with four adapter proteins, MyD88, TIRAP, TICAM-1 (Trif), and TICAM-2.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q23.1

Cellular Component: Golgi apparatus; late endosome membrane; endoplasmic reticulum; early endosome membrane; early endosome; late endosome; plasma membrane; endosome membrane

Molecular Function: signal transducer activity; phospholipid binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon-gamma production; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway; positive regulation of interleukin-6 production; innate immune response; toll-like receptor 3 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TICAM2 antibodyPathways associated with anti-TICAM2 antibody
 Reference Product  PubMed Publications
 IRAK1 antibody  >1 publications with TICAM2 and IRAK1
 Products by Pathway  Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram
 Toll-like Receptor Signaling Pathway antibodies  Toll-like Receptor Signaling Pathway Diagram
Diseases associated with anti-TICAM2 antibodyOrgans/Tissues associated with anti-TICAM2 antibody
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >1 publications with TICAM2 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with TICAM2 and Blood
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