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anti-TL1A antibody :: Rabbit anti-Human TL1A TL1A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS535934 anti-TL1A antibody
Unit / Price
0.05 mg  /  $370 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TL1A, Polyclonal Antibody

 Also Known As   

TL1A antibody

 Product Synonym Names    Polyclonal TL1A; Anti-TL1A; TL1A; TLA-1; TL-1A; TLA 1; TNFSF15; VEGI
 Product Gene Name   

anti-TL1A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604052
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human TL1A
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 Form/Format    Lyophilized from PBS, pH 7.2.
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 Biological Significance    TL-1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL-1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NF kb activation, caspase activity, and apoptosis in responding cell lines.
 Immunogen    TL1A antibody was raised in rabbit using highly pure recombinant human TL-1A as the immunogen.
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 Preparation and Storage    Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-TL1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TL1A antibody

   Affinity purified Rabbit polyclonal TL1A antibody
 Product Categories/Family for anti-TL1A antibody    Cytokines & Growth Factors; Purified Polyclonal Antibodies
 Applications Tested/Suitable for anti-TL1A antibody   

ELISA (EIA), Inhibition, Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for TL1A. It may not necessarily be applicable to this product.
 NCBI GI #    23510445
 NCBI GeneID    9966
 NCBI Accession #    NP_005109.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005118.3 [Other Products]
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 UniProt Secondary Accession #    Q3SX69; Q5VJK8; Q5VWH1; Q8NFE9 [Other Products]
 UniProt Related Accession #    O95150 [Other Products]
 Molecular Weight    22.0 kDa (predicted detection band MW)
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 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 15 isoform VEGI-251
 NCBI Official Synonym Full Names    tumor necrosis factor (ligand) superfamily, member 15
 NCBI Official Symbol    TNFSF15 [Similar Products]
 NCBI Official Synonym Symbols   
TL1; TL1A; VEGI; VEGI192A
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 15
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 15
 UniProt Synonym Protein Names   
TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor
 UniProt Gene Name    TNFSF15 [Similar Products]
 UniProt Synonym Gene Names    TL1; VEGI [Similar Products]
 UniProt Entry Name    TNF15_HUMAN
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 NCBI Summary for TL1A    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
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 UniProt Comments for TL1A    TNFSF15: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cytokine; Apoptosis

Chromosomal Location of Human Ortholog: 9q32

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: death receptor binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: caspase activation; cytokine metabolic process; activation of NF-kappaB-inducing kinase; immune response; signal transduction; positive regulation of cytokine secretion
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 Research Articles on TL1A    1. DR3 is expressed in some interstitial vascular endothelial cells (EC) in human kidney in situ; these EC also respond to its ligand TL1A by activating NF-kappaB.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TL1A antibodyPathways associated with anti-TL1A antibody
 Reference Product  PubMed Publications
 TNFRSF25 antibody  >40 publications with TL1A and TNFRSF25
 TNFRSF6B antibody  >15 publications with TL1A and TNFRSF6B
 IL13 antibody  >5 publications with TL1A and IL13
 IFNG antibody  >2 publications with TL1A and IFNG
 TNFSF4 antibody  >2 publications with TL1A and TNFSF4
 TNFRSF1A antibody  >1 publications with TL1A and TNFRSF1A
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
Diseases associated with anti-TL1A antibodyOrgans/Tissues associated with anti-TL1A antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >184 publications with TL1A and Necrosis
 Inflammation Antibodies  >52 publications with TL1A and Inflammation
 Colitis, Ulcerative Antibodies  >30 publications with TL1A and Colitis, Ulcerative
 Disease Models, Animal Antibodies  >14 publications with TL1A and Disease Models, Animal
 Enteritis Antibodies  >9 publications with TL1A and Enteritis
 Fibrosis Antibodies  >7 publications with TL1A and Fibrosis
 Atherosclerosis Antibodies  >6 publications with TL1A and Atherosclerosis
 Lung Diseases Antibodies  >5 publications with TL1A and Lung Diseases
 Cardiovascular Diseases Antibodies  >5 publications with TL1A and Cardiovascular Diseases
 Diarrhea Antibodies  >4 publications with TL1A and Diarrhea
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >99 publications with TL1A and Blood
 Intestine Antibodies  >28 publications with TL1A and Intestine
 Embryonic Tissue Antibodies  >10 publications with TL1A and Embryonic Tissue
 Kidney Antibodies  >9 publications with TL1A and Kidney
 Lung Antibodies  >8 publications with TL1A and Lung
 Brain Antibodies  >4 publications with TL1A and Brain
 Eye Antibodies  >4 publications with TL1A and Eye
 Thyroid Antibodies  >2 publications with TL1A and Thyroid
 Prostate Antibodies  >1 publications with TL1A and Prostate
 Testis Antibodies  >1 publications with TL1A and Testis
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