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anti-TLR2 antibody :: Goat TLR2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS448048 (SPECIAL PROMOTIONAL PRICING for a limited time)
Unit / Price
0.6 mg  /  $285 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TLR2, Polyclonal Antibody

★Popular Item★
 Also Known As   

TLR2 Polyclonal Antibody

 Product Synonym Names    Anti-TLR2; CD282; TIL4; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4 antibody
 Product Gene Name   

anti-TLR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.12 (153684252..153706091). Location: 4q32
 OMIM    246300
 3D Structure    ModBase 3D Structure for O60603
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Reacts against human, rat, mouse, canine, and monkey proteins
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 Specificity    Using liver, MDA-MD-435S and RAW264.7 cell lysates detects a band 85-90 kDa by Western blot.
 Form/Format    Polyclonal antibody supplied as (3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.
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 Gene Identifier    ENSG00000137462
 Immunogen    Purified recombinant peptide derived from within residues 736 aa to the C-terminus of human TLR2 produced in E. coli.
 Antigen    Purified recombinant peptide derived from within residues 736 aa to the C-terminus of human TLR2 produced in E. coli.
 Handling    The antibody solution should be gently mixed before use.
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 Preparation and Storage    Store at -20 degree C for long term storage. Store at 2-8 degree C for up to one month.Avoid freeze/thaw cycles
 Other Notes    Small volumes of anti-TLR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TLR2 antibody

   Toll-like receptor 2

Goat polyclonal antibody to TLR2. It is a 84 kDa type I transmembrane glycoprotein and a member of TLR family. It contains many leucine-rich repeat sequences and the intracellular Toll Interleukin Receptor Domain. TLR2 forms heterodimer with TLR1 and TLR6. It is expressed in peripheral blood leukocytes, and highly expressed in monocytes in bone marrow, lymph nodes, and spleen. It is also detectable in other tissues. This protein recognizes molecular patterns of bacteria, fungi, protozoan pathogens and stimulates pro-inflammatory cytokines as part of innate immunity.
 Applications Tested/Suitable for anti-TLR2 antibody   

Western Blot (WB)

 Application Notes for anti-TLR2 antibody    Western Blot: 1:500-1:2,000
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 Reactivity Chart of anti-TLR2 antibody    anti-TLR2 antibody Reactivity Chart image
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 Testing Data of anti-TLR2 antibody    anti-TLR2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for TLR2. It may not necessarily be applicable to this product.
 NCBI GI #    19718734
 NCBI GeneID    7097
 NCBI Accession #    NP_003255.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003264.3 [Other Products]
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 UniProt Primary Accession #    O60603 [Other Products]
 UniProt Secondary Accession #    O15454; Q8NI00; B3Y612; D1CS45; D1CS48; D1CS49 [Other Products]
 UniProt Related Accession #    O60603 [Other Products]
 Molecular Weight    89,838 Da
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 NCBI Official Full Name    toll-like receptor 2
 NCBI Official Synonym Full Names    toll-like receptor 2
 NCBI Official Symbol    TLR2 [Similar Products]
 NCBI Official Synonym Symbols   
TIL4; CD282
[Similar Products]
 NCBI Protein Information    toll-like receptor 2; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4
 UniProt Protein Name    Toll-like receptor 2
 UniProt Synonym Protein Names   
Toll/interleukin-1 receptor-like protein 4
 Protein Family    Toll-like receptor
 UniProt Gene Name    TLR2 [Similar Products]
 UniProt Synonym Gene Names    TIL4 [Similar Products]
 UniProt Entry Name    TLR2_HUMAN
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 NCBI Summary for TLR2    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TLR2    Function: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

Subunit structure: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 or TLR6. Interacts with CNPY3

By similarity. Interacts with ATG16L1. Ref.10 Ref.12

Subcellular location: Membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.

Domain: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12

By similarity.The ATG16L1-binding motif mediates interaction with ATG16L1 (Ref.12).

Post-translational modification: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.

Polymorphism: Genetic variations in TLR2 are associated with susceptibility to leprosy [

MIM:246300]. Leprosy is a chronic disease associated with depressed cellular (but not humoral) immunity, the bacterium requires a lower temperature than 37 degrees Celsius and thrives particularly in peripheral Schwann cells and macrophages. The Trp-677 polymorphism in the intracellular domain of TLR2 has a role in susceptibility to lepromatous leprosy. Wild-type TLR2 mediates CD14-enhanced Mycobacterium leprae-dependent activation of NFKB1, but TLR2 containing the Trp-677 polymorphism did not. The impaired function of the Trp-677 polymorphism provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy.

Sequence similarities: Belongs to the Toll-like receptor family.Contains 19 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 TIR domain.
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 Research Articles on TLR2    1. This study provides evidence that the TLR2 gene is involved in the susceptibility to ocular Behcet's disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TLR2 antibodyPathways associated with anti-TLR2 antibody
 Reference Product  PubMed Publications
 MYD88 antibody  >990 publications with TLR2 and MYD88
 CD14 antibody  >682 publications with TLR2 and CD14
 TLR1 antibody  >556 publications with TLR2 and TLR1
 TLR6 antibody  >418 publications with TLR2 and TLR6
 IL6 antibody  >114 publications with TLR2 and IL6
 TIRAP antibody  >108 publications with TLR2 and TIRAP
 LY96 antibody  >68 publications with TLR2 and LY96
 IRAK1 antibody  >52 publications with TLR2 and IRAK1
 TOLLIP antibody  >30 publications with TLR2 and TOLLIP
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Beta Defensins Pathway antibodies  Beta Defensins Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
Diseases associated with anti-TLR2 antibodyOrgans/Tissues associated with anti-TLR2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1821 publications with TLR2 and Inflammation
 Necrosis Antibodies  >1364 publications with TLR2 and Necrosis
 Disease Models, Animal Antibodies  >440 publications with TLR2 and Disease Models, Animal
 Lung Diseases Antibodies  >382 publications with TLR2 and Lung Diseases
 Neoplasms Antibodies  >250 publications with TLR2 and Neoplasms
 Atherosclerosis Antibodies  >191 publications with TLR2 and Atherosclerosis
 Liver Diseases Antibodies  >161 publications with TLR2 and Liver Diseases
 Asthma Antibodies  >130 publications with TLR2 and Asthma
 Heart Diseases Antibodies  >121 publications with TLR2 and Heart Diseases
 Fibrosis Antibodies  >102 publications with TLR2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2288 publications with TLR2 and Blood
 Lung Antibodies  >523 publications with TLR2 and Lung
 Bone Marrow Antibodies  >411 publications with TLR2 and Bone Marrow
 Liver Antibodies  >334 publications with TLR2 and Liver
 Brain Antibodies  >260 publications with TLR2 and Brain
 Kidney Antibodies  >250 publications with TLR2 and Kidney
 Skin Antibodies  >232 publications with TLR2 and Skin
 Heart Antibodies  >157 publications with TLR2 and Heart
 Muscle Antibodies  >155 publications with TLR2 and Muscle
 Mouth Antibodies  >142 publications with TLR2 and Mouth
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