Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow TLR4 rightarrow Polyclonal TLR4  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Collagen Type II (COL2) ELISA Kit
 • Lysolecithin ELISA Kit
 • Crystal Proteins beta (CRYbeta) ELISA Kit
 • Secreted Frizzled-Related Protein 1 (SFRP1) ELISA Kit
 • Placental Protein 13 (PP13) ELISA Kit
 • Heparin ELISA Kit
 • sCD4 ELISA Kit
 • Collagen Type VII (COL7) ELISA Kit
 • Alcohol Dehydrogenase 1 (ADH1) ELISA Kit
 • Endothelial-Leukocyte Adhesion Molecule 1 (ELAM-1) ELISA Kit
 • Kruppel Like Factor 15 (KLF15) ELISA Kit
 • sCD105-Soluble Endoglin ELISA Kit
 • Big Endothelin (BIG ET) ELISA Kit
 • Cyclophosphamide (CTX) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-TLR4 antibody :: Rabbit anti-Human TLR4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS5400094 anti-TLR4 antibody
Unit / Price
0.1 mg FITC  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TLR4, Polyclonal Antibody

 Also Known As   

TLR4 Antibody FITC-Conjugated

 Product Synonym Names    ARMD10; CD284; Homolog of Drosophila toll; hToll; TLR 4; Toll (Drosophila) homolog; TOLL; Toll Endotoxin Hyporesponsiveness; Toll like receptor 4 antibody
 Product Gene Name   

anti-TLR4 antibody

[Similar Products]
 Matching Pairs    Antibody: TLR4 (MBS5400094)
Positive Control: TLR4 (MBS543323)
 Antibody/Peptide Pairs    TLR4 peptide (MBS544579) is used for blocking the activity of TLR4 antibody (MBS5400094)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    603030
 3D Structure    ModBase 3D Structure for O00206
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Form/Format    FITC-Conjugated
 Concentration    0.66-0.8 ug/ul in antibody stabilization buffer (lot specific)
Section Bar
 Immunogen    Synthetic peptide taken within amino acid region 970-1000 on human TLR4 protein.
 Expression    Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.
 Molecular Function    Receptor, lipopolysaccharide binding, transmembrane signaling receptor activity
 Structure    Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via the
 Subcellular Location    Cell membrane; Single-pass type I membrane protein
Section Bar
 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-TLR4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-TLR4 antibody

   FITC-Conjugated Toll-like receptor 4 Antibody
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+.
 Applications Tested/Suitable for anti-TLR4 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TLR4 antibody    Dot Blot: 1:20,000
ELISA: 1:20,000
Western Blot: 1:500
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TLR4. It may not necessarily be applicable to this product.
 NCBI GI #    6175873
 NCBI GeneID    7099
 NCBI Accession #    AAF05316.1 [Other Products]
Section Bar
 UniProt Primary Accession #    O00206 [Other Products]
 UniProt Secondary Accession #    Q5VZI8; Q5VZI9; Q9UK78; Q9UM57; A8K1Y8; A9XLP9; A9XLQ0; A9XLQ1; B4E194; D1CS52; D1CS53 [Other Products]
 UniProt Related Accession #    O00206 [Other Products]
 Molecular Weight    73,301 Da
Table BarTOPTable Bar
 NCBI Official Full Name    toll-like receptor 4
 NCBI Official Synonym Full Names    toll like receptor 4
 NCBI Official Symbol    TLR4 [Similar Products]
 NCBI Official Synonym Symbols   
TOLL; CD284; TLR-4; ARMD10
[Similar Products]
 NCBI Protein Information    toll-like receptor 4
 UniProt Protein Name    Toll-like receptor 4
 UniProt Synonym Protein Names   
hToll; CD_antigen: CD284
 Protein Family    Toll-like receptor
 UniProt Gene Name    TLR4 [Similar Products]
 UniProt Entry Name    TLR4_HUMAN
Section Bar
 NCBI Summary for TLR4    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Section Bar
 UniProt Comments for TLR4    TLR4: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS- independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific. Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4. Interacts with CNPY3. Interacts with HSP90B1. The interaction with both CNPY3 and HSP90B1 is required for proper folding in the endoplasmic reticulum. Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells. Belongs to the Toll-like receptor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 9q33.1

Cellular Component: cell surface; cytoplasm; endosome membrane; external side of plasma membrane; integral to plasma membrane; intrinsic to plasma membrane; lipopolysaccharide receptor complex; perinuclear region of cytoplasm; plasma membrane

Molecular Function: lipopolysaccharide binding; lipopolysaccharide receptor activity; protein binding; receptor activity; transmembrane receptor activity

Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; astrocyte development; B cell proliferation during immune response; defense response to bacterium; defense response to Gram-negative bacterium; detection of fungus; detection of lipopolysaccharide; I-kappaB kinase/NF-kappaB cascade; I-kappaB phosphorylation; immune response; inflammatory response; innate immune response; interferon-gamma production; interleukin-1 beta secretion; lipopolysaccharide-mediated signaling pathway; macrophage activation; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of interferon-gamma production; negative regulation of interleukin-17 production; negative regulation of interleukin-23 production; negative regulation of interleukin-6 production; negative regulation of MyD88-independent toll-like receptor signaling pathway; negative regulation of osteoclast differentiation; negative regulation of tumor necrosis factor production; positive regulation of B cell proliferation; positive regulation of chemokine production; positive regulation of inflammatory response; positive regulation of interferon-alpha production; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of interferon-gamma production; positive regulation of interleukin-1 production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 biosynthetic process; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 biosynthetic process; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of MHC class II biosynthetic process; positive regulation of NF-kappaB import into nucleus; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor production; production of nitric oxide during acute inflammatory response; regulation of cytokine secretion; regulation of dendritic cell cytokine production; response to lipopolysaccharide; T-helper 1 type immune response; toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway

Disease: Macular Degeneration, Age-related, 10
Table BarTOPTable Bar
 Research Articles on TLR4    1. Authors determined the effects of T. suis soluble products (SPs) on Toll-like receptor-4 (TLR4)- In addition, T. suis SPs induce Rab7b, a negative regulator of TLR4 signalling
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-TLR4 antibodyDiseases associated with anti-TLR4 antibody
 Reference Product  PubMed Publications
 MYD88 antibody  >2165 publications with TLR4 and MYD88
 HMGB1 antibody  >543 publications with TLR4 and HMGB1
 LY96 antibody  >356 publications with TLR4 and LY96
 IRAK2 antibody  >271 publications with TLR4 and IRAK2
 TRAF6 antibody  >265 publications with TLR4 and TRAF6
 TIRAP antibody  >193 publications with TLR4 and TIRAP
 TICAM1 antibody  >115 publications with TLR4 and TICAM1
 IRAK4 antibody  >87 publications with TLR4 and IRAK4
 TICAM2 antibody  >30 publications with TLR4 and TICAM2
 TRAF3 antibody  >22 publications with TLR4 and TRAF3
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4971 publications with TLR4 and Inflammation
 Necrosis Antibodies  >3045 publications with TLR4 and Necrosis
 Sepsis Antibodies  >920 publications with TLR4 and Sepsis
 Liver Diseases Antibodies  >596 publications with TLR4 and Liver Diseases
 Atherosclerosis Antibodies  >491 publications with TLR4 and Atherosclerosis
 Reperfusion Injury Antibodies  >392 publications with TLR4 and Reperfusion Injury
 Lung Injury Antibodies  >382 publications with TLR4 and Lung Injury
 Heart Diseases Antibodies  >341 publications with TLR4 and Heart Diseases
 Fibrosis Antibodies  >314 publications with TLR4 and Fibrosis
 Carcinoma Antibodies  >276 publications with TLR4 and Carcinoma
Organs/Tissues associated with anti-TLR4 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4731 publications with TLR4 and Blood
 Lung Antibodies  >1176 publications with TLR4 and Lung
 Liver Antibodies  >1142 publications with TLR4 and Liver
 Bone Antibodies  >1028 publications with TLR4 and Bone
 Bone Marrow Antibodies  >842 publications with TLR4 and Bone Marrow
 Vascular Antibodies  >817 publications with TLR4 and Vascular
 Brain Antibodies  >806 publications with TLR4 and Brain
 Intestine Antibodies  >701 publications with TLR4 and Intestine
 Kidney Antibodies  >542 publications with TLR4 and Kidney
 Muscle Antibodies  >524 publications with TLR4 and Muscle
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions