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anti-TLR5 antibody :: Rabbit TLR5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS540533 anti-TLR5 antibody
Unit / Price
0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TLR5, Polyclonal Antibody

★Popular Item★
 Also Known As   

TLR5 Antibody

 Product Synonym Names    SLEB1; TIL3; Toll like receptor 5; Toll/interleukin 1 receptor like protein 3 antibody
 Product Gene Name   

anti-TLR5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109100
 3D Structure    ModBase 3D Structure for O60602
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Cat, Human, Mouse, Pig
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 Form/Format    Affinity Purified
 Concentration    0.75 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide taken within amino acid region 195-225 on human TLR5 protein.
 Expression    Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.
 Molecular Function    Receptor, interleukin-1 receptor binding, transmembrane signalling receptor activity
 Structure    Binds MYD88 via their respective TIR domains (By similarity). Homodimer both in the absence and presence of ligand.
 Subcellular Location    Membrane; Single-pass type I membrane protein
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-TLR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TLR5 antibody

   Affinity Purified Toll-like receptor 5 Antibody
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
 Product Categories/Family for anti-TLR5 antibody    Primary Antibodies; Immunology; Innate Immunity; Macrophage / Inflammation; TLR5 Antibody
 Applications Tested/Suitable for anti-TLR5 antibody   

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-TLR5 antibody    Dot Blot: 1:20,000
ELISA: 1:20,000
Immunoprecipitation: 1:200
Western Blot: 1:500
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NCBI/Uniprot data below describe general gene information for TLR5. It may not necessarily be applicable to this product.
 NCBI GI #    215274239
 NCBI GeneID    7100
 NCBI Accession #    O60602.4 [Other Products]
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 UniProt Primary Accession #    O60602 [Other Products]
 UniProt Secondary Accession #    O15456; Q32MI2; Q32MI3; B1AZ05; B3Y633; B9VJ63; D1CS80; D3DTB8 [Other Products]
 UniProt Related Accession #    O60602 [Other Products]
 Molecular Weight    97,834 Da
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 NCBI Official Full Name    Toll-like receptor 5
 NCBI Official Synonym Full Names    toll like receptor 5
 NCBI Official Symbol    TLR5 [Similar Products]
 NCBI Official Synonym Symbols   
SLE1; TIL3; SLEB1; MELIOS
[Similar Products]
 NCBI Protein Information    toll-like receptor 5
 UniProt Protein Name    Toll-like receptor 5
 UniProt Synonym Protein Names   
Toll/interleukin-1 receptor-like protein 3
 Protein Family    Toll-like receptor
 UniProt Gene Name    TLR5 [Similar Products]
 UniProt Synonym Gene Names    TIL3 [Similar Products]
 UniProt Entry Name    TLR5_HUMAN
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 NCBI Summary for TLR5    This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
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 UniProt Comments for TLR5    TLR5: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the Toll-like receptor family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q41-q42

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: interleukin-1 receptor binding; receptor activity; transmembrane receptor activity

Biological Process: defense response to Gram-negative bacterium; inflammatory response; innate immune response; male gonad development; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of nitric oxide biosynthetic process; positive regulation of toll-like receptor signaling pathway; regulation of cytokine secretion; toll-like receptor 5 signaling pathway

Disease: Legionnaire Disease, Susceptibility To; Melioidosis, Susceptibility To; Systemic Lupus Erythematosus, Susceptibility To, 1
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 Research Articles on TLR5    1. p53-dependent amplification of transcriptional response to TLR5 activation required expression of NFkappaB subunit p65 and was mediated by several molecular mechanisms
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TLR5 antibodyPathways associated with anti-TLR5 antibody
 Reference Product  PubMed Publications
 MYD88 antibody  >153 publications with TLR5 and MYD88
 IL17C antibody  >21 publications with TLR5 and IL17C
 RELA antibody  >13 publications with TLR5 and RELA
 ICAM1 antibody  >11 publications with TLR5 and ICAM1
 IRAK4 antibody  >8 publications with TLR5 and IRAK4
 DUOX2 antibody  >2 publications with TLR5 and DUOX2
 NFKB1 antibody  >2 publications with TLR5 and NFKB1
 SIGIRR antibody  >1 publications with TLR5 and SIGIRR
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With The TLR Signaling Cascade Pathway antibodies  Diseases Associated With The TLR Signaling Cascade Pathway Diagram
 Diseases Of Immune System Pathway antibodies  Diseases Of Immune System Pathway Diagram
 IRAK4 Deficiency (TLR5) Pathway antibodies  IRAK4 Deficiency (TLR5) Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
Diseases associated with anti-TLR5 antibodyOrgans/Tissues associated with anti-TLR5 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >319 publications with TLR5 and Inflammation
 Necrosis Antibodies  >135 publications with TLR5 and Necrosis
 Lung Diseases Antibodies  >68 publications with TLR5 and Lung Diseases
 Fibrosis Antibodies  >33 publications with TLR5 and Fibrosis
 Liver Diseases Antibodies  >31 publications with TLR5 and Liver Diseases
 Kidney Diseases Antibodies  >24 publications with TLR5 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >24 publications with TLR5 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >14 publications with TLR5 and Neoplasms, Experimental
 Lupus Erythematosus, Systemic Antibodies  >14 publications with TLR5 and Lupus Erythematosus, Systemic
 Heart Diseases Antibodies  >11 publications with TLR5 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >119 publications with TLR5 and Lung
 Liver Antibodies  >62 publications with TLR5 and Liver
 Kidney Antibodies  >52 publications with TLR5 and Kidney
 Skin Antibodies  >40 publications with TLR5 and Skin
 Brain Antibodies  >24 publications with TLR5 and Brain
 Uterus Antibodies  >21 publications with TLR5 and Uterus
 Mouth Antibodies  >18 publications with TLR5 and Mouth
 Connective Tissue Antibodies  >8 publications with TLR5 and Connective Tissue
 Ovary Antibodies  >7 publications with TLR5 and Ovary
 Trachea Antibodies  >7 publications with TLR5 and Trachea
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