NP_058624.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
toll-like receptor 5
NCBI Official Synonym Full Names
toll-like receptor 5
NCBI Protein Information
toll-like receptor 5
UniProt Protein Name
Toll-like receptor 5
UniProt Entry Name
TLR5_MOUSE
UniProt Comments for Tlr5
TLR5: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the Toll-like receptor family.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: membrane; integral to membrane
Molecular Function: protein binding; transmembrane receptor activity; interleukin-1 receptor binding
Biological Process: toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of cytokine production; regulation of cytokine secretion; positive regulation of nitric oxide biosynthetic process; immune system process; defense response to bacterium; innate immune response; inflammatory response; signal transduction; positive regulation of toll-like receptor signaling pathway
Product References and Citations for anti-Tlr5 antibody
Sebastiani, G., et al., Genomics 64(3):230-240 (2000).
Research Articles on Tlr5
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Products associated with anti-Tlr5 antibody
Diseases associated with anti-Tlr5 antibody
Organs/Tissues associated with anti-Tlr5 antibody
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