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anti-TLR8 antibody :: Rabbit TLR8 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2522945
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TLR8, Polyclonal Antibody

★Popular Item★
 Also Known As   

TLR8 Polyclonal Antibody

 Product Synonym Names    CD288
 Product Gene Name   

anti-TLR8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300366
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    2mg/mL (lot specific)
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 Immunogen    Recombinant protein of human TLR8
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TLR8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TLR8 antibody

   The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
 Product Categories/Family for anti-TLR8 antibody    Epigenetics
 Applications Tested/Suitable for anti-TLR8 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-TLR8 antibody    IHC: 1:50-1:200
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 Immunohistochemistry (IHC) of anti-TLR8 antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TLR8 Polyclonal Antibody at dilution 1:40
anti-TLR8 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TLR8 antibody    Immunohistochemistry of paraffin-embedded Human colon cancer tissue using TLR8 Polyclonal Antibody at dilution 1:40
anti-TLR8 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TLR8. It may not necessarily be applicable to this product.
 NCBI GI #    20302168
 NCBI GeneID    51311
 NCBI Accession #    NP_619542.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_138636.5 [Other Products]
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 UniProt Secondary Accession #    Q495P4; Q6UXL6; Q9NYG9; B3Y654; D1CS70; D1CS76 [Other Products]
 UniProt Related Accession #    Q9NR97 [Other Products]
 Molecular Weight    121,764 Da
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 NCBI Official Full Name    toll-like receptor 8 isoform 2
 NCBI Official Synonym Full Names    toll-like receptor 8
 NCBI Official Symbol    TLR8 [Similar Products]
 NCBI Official Synonym Symbols   
CD288
[Similar Products]
 NCBI Protein Information    toll-like receptor 8
 UniProt Protein Name    Toll-like receptor 8
 UniProt Synonym Protein Names   
CD_antigen: CD288
 Protein Family    Toll-like receptor
 UniProt Gene Name    TLR8 [Similar Products]
 UniProt Entry Name    TLR8_HUMAN
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 NCBI Summary for TLR8    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TLR8    TLR8: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane; endosome membrane

Molecular Function: single-stranded RNA binding; DNA binding; RNA binding; double-stranded RNA binding; receptor activity; drug binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; regulation of cytokine secretion; response to virus; positive regulation of interleukin-8 biosynthetic process; microglial cell activation; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 8 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of innate immune response; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; immunoglobulin mediated immune response; inflammatory response; defense response to virus; positive regulation of interferon-gamma biosynthetic process
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 Research Articles on TLR8    1. In vitro treatment of PBMCs with R484 hijacks the pro inflammatory immune process triggered by TLRs7/8 to mediate anti-inflammatory response.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TLR8 antibodyPathways associated with anti-TLR8 antibody
 Reference Product  PubMed Publications
 TLR7 antibody  >450 publications with TLR8 and TLR7
 TLR9 antibody  >231 publications with TLR8 and TLR9
 TLR3 antibody  >224 publications with TLR8 and TLR3
 MYD88 antibody  >71 publications with TLR8 and MYD88
 CD40 antibody  >16 publications with TLR8 and CD40
 UNC93B1 antibody  >8 publications with TLR8 and UNC93B1
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram
 Regulation Of Toll-like Receptor Signaling Pathway antibodies  Regulation Of Toll-like Receptor Signaling Pathway Diagram
 TRAF6 Mediated IRF7 Activation In TLR7/8 Or 9 Signaling Pathway antibodies  TRAF6 Mediated IRF7 Activation In TLR7/8 Or 9 Signaling Pathway Diagram
 TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation Pathway antibodies  TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation Pathway Diagram
 Toll Like Receptor 7/8 (TLR7/8) Cascade Pathway antibodies  Toll Like Receptor 7/8 (TLR7/8) Cascade Pathway Diagram
 Toll Like Receptor 9 (TLR9) Cascade Pathway antibodies  Toll Like Receptor 9 (TLR9) Cascade Pathway Diagram
 Toll-Like Receptors Cascades Pathway antibodies  Toll-Like Receptors Cascades Pathway Diagram
 Toll-like Receptor Signaling Pathway antibodies  Toll-like Receptor Signaling Pathway Diagram
Diseases associated with anti-TLR8 antibodyOrgans/Tissues associated with anti-TLR8 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >121 publications with TLR8 and Inflammation
 Necrosis Antibodies  >91 publications with TLR8 and Necrosis
 Skin Diseases Antibodies  >27 publications with TLR8 and Skin Diseases
 Lung Diseases Antibodies  >22 publications with TLR8 and Lung Diseases
 Death Antibodies  >14 publications with TLR8 and Death
 Heart Diseases Antibodies  >11 publications with TLR8 and Heart Diseases
 Skin Neoplasms Antibodies  >10 publications with TLR8 and Skin Neoplasms
 Kidney Diseases Antibodies  >9 publications with TLR8 and Kidney Diseases
 Fibrosis Antibodies  >7 publications with TLR8 and Fibrosis
 Uterine Cervical Neoplasms Antibodies  >4 publications with TLR8 and Uterine Cervical Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >301 publications with TLR8 and Blood
 Lung Antibodies  >36 publications with TLR8 and Lung
 Spleen Antibodies  >27 publications with TLR8 and Spleen
 Brain Antibodies  >22 publications with TLR8 and Brain
 Kidney Antibodies  >21 publications with TLR8 and Kidney
 Intestine Antibodies  >15 publications with TLR8 and Intestine
 Vascular Antibodies  >13 publications with TLR8 and Vascular
 Uterus Antibodies  >8 publications with TLR8 and Uterus
 Placenta Antibodies  >5 publications with TLR8 and Placenta
 Connective Tissue Antibodies  >3 publications with TLR8 and Connective Tissue
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