NP_057694.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
toll-like receptor 8 isoform 1
NCBI Official Synonym Full Names
toll-like receptor 8
NCBI Official Synonym Symbols
NCBI Protein Information
toll-like receptor 8
UniProt Protein Name
Toll-like receptor 8
UniProt Synonym Protein Names
CD_antigen: CD288
UniProt Entry Name
TLR8_HUMAN
NCBI Summary for TLR8
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
UniProt Comments for TLR8
TLR8: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: Xp22
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane; endosome membrane
Molecular Function: single-stranded RNA binding; DNA binding; RNA binding; double-stranded RNA binding; receptor activity; drug binding
Biological Process: I-kappaB kinase/NF-kappaB cascade; regulation of cytokine secretion; response to virus; positive regulation of interleukin-8 biosynthetic process; microglial cell activation; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 8 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of innate immune response; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; immunoglobulin mediated immune response; toll-like receptor 9 signaling pathway; inflammatory response; defense response to virus; positive regulation of interferon-gamma biosynthetic process
Research Articles on TLR8
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Products associated with anti-TLR8 antibody
Pathways associated with anti-TLR8 antibody
Diseases associated with anti-TLR8 antibody
Organs/Tissues associated with anti-TLR8 antibody
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