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anti-TMED10 antibody :: Rabbit anti-Human, Mouse TMED10 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7044754
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TMED10, Polyclonal Antibody

★Popular Item★
 Also Known As   

TMED10 Antibody

 Product Synonym Names    Transmembrane emp24 domain-containing protein 10; 21 kDa transmembrane-trafficking protein; S31III125; S31I125; Tmp-21-I; Transmembrane protein Tmp21; p23; p24 family protein delta-1; p24delta1; p24delta; TMED10; TMP21
 Product Gene Name   

anti-TMED10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605406
 3D Structure    ModBase 3D Structure for P49755
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Transmembrane emp24 domain-containing protein 10 protein (35-190AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-68398
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TMED10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TMED10 antibody

   Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus.
 Applications Tested/Suitable for anti-TMED10 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-TMED10 antibody    Western blot
All lanes:  TMED10antibody at 4.88ug/ml
Lane 1 : Hela whole cell lysate
Lane 2 : Mouse liver tissue
Lane 3 : Mouse lung tissue
Lane 4 : 293T whole cell lysate
Lane 5 : NIH/3T3 whole cell lysate
Lane 6 : U87 whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 25 kDa
Observed band size: 25 kDa

anti-TMED10 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TMED10 antibody    Immunohistochemistry of paraffin-embedded human testis tissue using MBS7044754 at dilution 1:100
anti-TMED10 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TMED10 antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7044754 at dilution 1:100
anti-TMED10 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TMED10. It may not necessarily be applicable to this product.
 NCBI GI #    98986464
 NCBI GeneID    10972
 NCBI Accession #    NP_006818.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_006827.5 [Other Products]
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 UniProt Primary Accession #    P49755 [Other Products]
 UniProt Secondary Accession #    Q15602; Q16536; Q86TC2; Q86TS5; B2R605 [Other Products]
 UniProt Related Accession #    P49755 [Other Products]
 Molecular Weight    24,976 Da
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 NCBI Official Full Name    transmembrane emp24 domain-containing protein 10
 NCBI Official Synonym Full Names    transmembrane p24 trafficking protein 10
 NCBI Official Symbol    TMED10 [Similar Products]
 NCBI Official Synonym Symbols   
p23; TMP21; p24d1; S31I125; Tmp-21-I; S31III125; P24(DELTA)
[Similar Products]
 NCBI Protein Information    transmembrane emp24 domain-containing protein 10
 UniProt Protein Name    Transmembrane emp24 domain-containing protein 10
 UniProt Synonym Protein Names   
21 kDa transmembrane-trafficking protein; S31III125; S31I125; Tmp-21-I; Transmembrane protein Tmp21; p23; p24 family protein delta-1; p24delta1; p24delta
 Protein Family    Transmembrane protein
 UniProt Gene Name    TMED10 [Similar Products]
 UniProt Synonym Gene Names    TMP21; S31I125; p24delta1 [Similar Products]
 UniProt Entry Name    TMEDA_HUMAN
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 NCBI Summary for TMED10    This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TMED10    TMED10: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus. Predominantly homodimeric and to lesser extent monomeric in endoplasmic reticulum. Homodimer and monomer in endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED7 and TMED9. Interacts with TMED2. Associates with the COPI vesicle coat (coatomer); TMED10:TMED2 heterotetramers are proposed to be involved in coatomer association. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED10. Interacts with ARF1 (GDP- bound); the interaction probably involves a TMED10 oligomer. Interacts with SEC23A; indicative for an association of TMED10 with the COPII vesicle coat. Interacts with CD59, SEC24B, SEC24C and SEC24D. Interacts with MPPE1/PGAP5. Interacts with F2LR1. Interacts with KDELR2; the interaction is disrupted by KDELR2 ligand. Found in a complex composed at least of SURF4, TMED2 and TMED10. Associates with the presenilin- dependent gamma-secretase complex. Ubiquitous. Belongs to the EMP24/GP25L family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: cis-Golgi network; COPI-coated vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; ER-Golgi intermediate compartment; ER-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; integral to membrane; plasma membrane; secretory granule membrane; trans-Golgi network transport vesicle; transport vesicle; zymogen granule membrane

Molecular Function: protein binding; syntaxin binding

Biological Process: COPI coating of Golgi vesicle; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; intracellular protein transport; regulated secretory pathway; retrograde vesicle-mediated transport, Golgi to ER; vesicle targeting, to, from or within Golgi
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 Research Articles on TMED10    1. Study demonstrates that NleF binds to the human Tmp21 protein and subsequently disrupts intracellular protein trafficking.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TMED10 antibodyPathways associated with anti-TMED10 antibody
 Reference Product  PubMed Publications
 TMED7 antibody  >1 publications with TMED10 and TMED7
 TMED2 antibody  >1 publications with TMED10 and TMED2
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 COPI-dependent Golgi-to-ER Retrograde Traffic Pathway antibodies  COPI-dependent Golgi-to-ER Retrograde Traffic Pathway Diagram
 COPI-mediated Anterograde Transport Pathway antibodies  COPI-mediated Anterograde Transport Pathway Diagram
 COPII (Coat Protein 2) Mediated Vesicle Transport Pathway antibodies  COPII (Coat Protein 2) Mediated Vesicle Transport Pathway Diagram
 Cargo Concentration In The ER Pathway antibodies  Cargo Concentration In The ER Pathway Diagram
 ER To Golgi Anterograde Transport Pathway antibodies  ER To Golgi Anterograde Transport Pathway Diagram
 Golgi-to-ER Retrograde Transport Pathway antibodies  Golgi-to-ER Retrograde Transport Pathway Diagram
 Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway antibodies  Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
Diseases associated with anti-TMED10 antibodyOrgans/Tissues associated with anti-TMED10 antibody
 Disease Name  Pubmed Publications
 Death Antibodies  >2 publications with TMED10 and Death
 Carcinoma, Hepatocellular Antibodies  >1 publications with TMED10 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >1 publications with TMED10 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1 publications with TMED10 and Vascular
 Bone Antibodies  >1 publications with TMED10 and Bone
 Heart Antibodies  >1 publications with TMED10 and Heart
 Connective Tissue Antibodies  >1 publications with TMED10 and Connective Tissue
 Placenta Antibodies  >1 publications with TMED10 and Placenta
 Embryonic Tissue Antibodies  >1 publications with TMED10 and Embryonic Tissue
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