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anti-TMEM184C antibody :: Rabbit TMEM184C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151029
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TMEM184C, Polyclonal Antibody

 Also Known As   

TMEM184C Antibody

 Product Synonym Names    TMEM184C; TMEM34; TMEM34; PRO1355; Transmembrane protein 184C; Transmembrane protein 34; transmembrane protein 184C
 Product Gene Name   

anti-TMEM184C antibody

[Similar Products]
 Antibody/Peptide Pairs    TMEM184C peptide (MBS152228) is used for blocking the activity of TMEM184C antibody (MBS151029)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    613937
 3D Structure    ModBase 3D Structure for Q9NVA4
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    TMEM184C Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    TMEM184C antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TMEM184C.
 Buffer    TMEM184C Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    TMEM184C antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-TMEM184C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TMEM184C antibody

   TMEM184C Antibody: Anaplastic thyroid cancer is one of the most lethal forms of cancer, but the precise carcinogenic mechanism has not been identified. TMEM184C, also known as TMEM34, was identified in a cDNA microarray analysis as being down-regulated in anaplastic thyroid cancers compared to normal thyroid tissues. TMEM184C protein expression was also lower in cell lines derived from these types of cancers compared to that of normal thyroid tissues or cell lines based on other types of thyroid cancers. Furthermore, transfection of TMEM34 into KTA2 cells led to the inhibition of cell growth, suggesting that TMEM184C might act as a tumor suppressor in anaplastic thyroid cancers.
 Applications Tested/Suitable for anti-TMEM184C antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-TMEM184C antibody    TMEM184C antibody can be used for detection of TMEM184C by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-TMEM184C antibody    Western blot analysis of TMEM184C in mouse heart tissue lysate with TMEM184C antibody at 1 μg/mL.
anti-TMEM184C antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-TMEM184C antibody    Immunofluorescence of TMEM184C in mouse heart tissue with TMEM184B antibody at 20 μg/mL.
anti-TMEM184C antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-TMEM184C antibody    Immunohistochemistry of TMEM184C in mouse heart tissue with TMEM184C antibody at 5 μg/mL.
anti-TMEM184C antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TMEM184C. It may not necessarily be applicable to this product.
 NCBI GI #    190358512
 NCBI GeneID    55751
 NCBI Accession #    NP_060711 [Other Products]
 NCBI GenBank Nucleotide #    NM_018241.2 [Other Products]
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 UniProt Primary Accession #    Q9NVA4 [Other Products]
 UniProt Secondary Accession #    Q86X84; Q969I7; Q9NXM2; D3DP04 [Other Products]
 UniProt Related Accession #    Q9NVA4 [Other Products]
 Molecular Weight    30,522 Da
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 NCBI Official Full Name    transmembrane protein 184C
 NCBI Official Synonym Full Names    transmembrane protein 184C
 NCBI Official Symbol    TMEM184C [Similar Products]
 NCBI Official Synonym Symbols   
TMEM34
[Similar Products]
 NCBI Protein Information    transmembrane protein 184C; transmembrane protein 34
 UniProt Protein Name    Transmembrane protein 184C
 UniProt Synonym Protein Names   
Transmembrane protein 34
 Protein Family    Transmembrane protein
 UniProt Gene Name    TMEM184C [Similar Products]
 UniProt Synonym Gene Names    TMEM34 [Similar Products]
 UniProt Entry Name    T184C_HUMAN
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 UniProt Comments for TMEM184C    TMEM184C: Possible tumor suppressor which may play a role in cell growth. Belongs to the TMEM184 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q31.23

Cellular Component: integral to membrane
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 Research Articles on TMEM184C    1. Recently, by cDNA microarray anal., we identified transmembrane protein 34 (TMEM34) that down-regulated in anaplastic thyroid cancer cell lines as compared to normal thyroid tissues. Transfection of TMEM34 into KTA2 cells led to inhibition of cell growth
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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