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anti-TMPRSS11D antibody :: Goat TMPRSS11D/HAT Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421933 anti-TMPRSS11D antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TMPRSS11D/HAT, Polyclonal Antibody

 Also Known As   

Goat anti-TMPRSS11D/HAT Antibody

 Product Synonym Names    TMPRSS11D; transmembrane protease, serine 11D; HAT; MGC150587; MGC150588; airway trypsin like protease; airway trypsin-like protease; TMPRSS11D antibody; transmembrane protease; serine 11D antibody; HAT antibody; MGC150587 antibody; MGC150588 antibody; airway trypsin like protease antibody; airway trypsin-like protease antibody; TMPRSS11D / HAT
 Product Gene Name   

anti-TMPRSS11D antibody

[Similar Products]
 Product Synonym Gene Name    HAT [Similar Products]
 Antibody/Peptide Pairs    TMPRSS11D / HAT peptide (MBS425138) is used for blocking the activity of TMPRSS11D/HAT antibody (MBS421933)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    HNNYKSATHE ND
 OMIM    605369
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-HNNYKSATHEND, from the internal region of the protein sequence according to NP_004253.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-TMPRSS11D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TMPRSS11D antibody   

Peptide ELISA (EIA)

 Application Notes for anti-TMPRSS11D antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Preliminary experiments gave an approx 20kDa band in lysates of HepG2 after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 46.3kDa according to NP_004253.1. The 20kDa band was successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for TMPRSS11D. It may not necessarily be applicable to this product.
 NCBI GI #    4758508
 NCBI GeneID    9407
 NCBI Accession #    NP_004253.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004262.2 [Other Products]
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 UniProt Secondary Accession #    Q08AF6 [Other Products]
 UniProt Related Accession #    O60235 [Other Products]
 Molecular Weight    46,263 Da
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 NCBI Official Full Name    transmembrane protease serine 11D
 NCBI Official Synonym Full Names    transmembrane protease, serine 11D
 NCBI Official Symbol    TMPRSS11D [Similar Products]
 NCBI Official Synonym Symbols   
HAT
[Similar Products]
 NCBI Protein Information    transmembrane protease serine 11D
 UniProt Protein Name    Transmembrane protease serine 11D
 UniProt Synonym Protein Names   
Airway trypsin-like protease
 Protein Family    Transmembrane protease serine
 UniProt Gene Name    TMPRSS11D [Similar Products]
 UniProt Synonym Gene Names    HAT [Similar Products]
 UniProt Entry Name    TM11D_HUMAN
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 NCBI Summary for TMPRSS11D    This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TMPRSS11D    TMPRSS11D: May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Belongs to the peptidase S1 family.

Protein type: EC 3.4.21.-; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 4q13.2

Cellular Component: extracellular region; integral to plasma membrane

Molecular Function: peptidase activity; serine-type endopeptidase activity

Biological Process: proteolysis; respiratory gaseous exchange
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 Research Articles on TMPRSS11D    1. H9N2 viruses with R-S-S-R or R-S-R-R cleavage sites in hemagglutinin are activated by matriptase in addition to HAT and TMPRSS2 and, therefore, can be activated in a wide range of tissues what may affect virus spread, tissue tropism and pathogenicity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-TMPRSS11D antibodyOrgans/Tissues associated with anti-TMPRSS11D antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >1 publications with TMPRSS11D and Kidney Diseases
 Necrosis Antibodies  >1 publications with TMPRSS11D and Necrosis
 Weight Loss Antibodies  >1 publications with TMPRSS11D and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Trachea Antibodies  >1 publications with TMPRSS11D and Trachea
 Uterus Antibodies  >1 publications with TMPRSS11D and Uterus
 Uncharacterized Tissue Antibodies  >1 publications with TMPRSS11D and Uncharacterized Tissue
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