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anti-TRAF1 antibody :: Rabbit TNF receptor-associated factor 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS714029 anti-TRAF1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TNF receptor-associated factor 1 (TRAF1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human TNF receptor-associated factor 1 polyclonal Antibody

 Product Synonym Names    TNF receptor-associated factor 1; TRAF1; EBI6; MGC:10353
 Product Gene Name   

anti-TRAF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601711
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human TRAF1
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1831 / sc-1830 / sc-983 / sc-7186
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TRAF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TRAF1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for TRAF1. It may not necessarily be applicable to this product.
 NCBI GI #    6707734
 NCBI GeneID    7185
 NCBI Accession #    Q13077.1 [Other Products]
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 UniProt Secondary Accession #    Q658U1; Q8NF13; B4DJ77 [Other Products]
 UniProt Related Accession #    Q13077 [Other Products]
 Molecular Weight    33,296 Da [Similar Products]
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 NCBI Official Full Name    TNF receptor-associated factor 1
 NCBI Official Synonym Full Names    TNF receptor-associated factor 1
 NCBI Official Symbol    TRAF1 [Similar Products]
 NCBI Official Synonym Symbols   
EBI6; MGC:10353
[Similar Products]
 NCBI Protein Information    TNF receptor-associated factor 1; Epstein-Bar virus-induced protein 6
 UniProt Protein Name    TNF receptor-associated factor 1
 UniProt Synonym Protein Names   
Epstein-Barr virus-induced protein 6
 Protein Family    TNF receptor-associated factor
 UniProt Gene Name    TRAF1 [Similar Products]
 UniProt Synonym Gene Names    EBI6 [Similar Products]
 UniProt Entry Name    TRAF1_HUMAN
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 NCBI Summary for TRAF1    The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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 UniProt Comments for TRAF1    TRAF1: Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Homotrimer. Heterotrimer with TRAF2. Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2. Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2. Interacts with NFATC2IP, TRAFD1 and with HIVEP3. Interacts with MAP3K14. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q33-q34

Cellular Component: cytoplasm

Molecular Function: protein binding; zinc ion binding; thioesterase binding; ubiquitin protein ligase binding; tumor necrosis factor receptor binding

Biological Process: apoptosis; protein complex assembly; signal transduction; activation of NF-kappaB transcription factor
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 Research Articles on TRAF1    1. These findings suggest that the rs0818488 in TRAF1/C5 region is not associated with rheumatoid arthritis in Iranian population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TRAF1 antibodyPathways associated with anti-TRAF1 antibody
 Reference Product  PubMed Publications
 TRAF2 antibody  >223 publications with TRAF1 and TRAF2
 TRADD antibody  >153 publications with TRAF1 and TRADD
 CD40 antibody  >81 publications with TRAF1 and CD40
 CASP8 antibody  >55 publications with TRAF1 and CASP8
 RIPK1 antibody  >34 publications with TRAF1 and RIPK1
 BIRC2 antibody  >12 publications with TRAF1 and BIRC2
 BIRC3 antibody  >7 publications with TRAF1 and BIRC3
 TNFRSF1A antibody  >3 publications with TRAF1 and TNFRSF1A
 TNFRSF1B antibody  >3 publications with TRAF1 and TNFRSF1B
 CD40LG antibody  >2 publications with TRAF1 and CD40LG
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 EBV LMP1 Signaling Pathway antibodies  EBV LMP1 Signaling Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 HIV-1 Nef: Negative Effector Of Fas And TNF-alpha Pathway antibodies  HIV-1 Nef: Negative Effector Of Fas And TNF-alpha Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
Diseases associated with anti-TRAF1 antibodyOrgans/Tissues associated with anti-TRAF1 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >411 publications with TRAF1 and Necrosis
 Arthritis, Rheumatoid Antibodies  >85 publications with TRAF1 and Arthritis, Rheumatoid
 Inflammation Antibodies  >59 publications with TRAF1 and Inflammation
 Carcinoma Antibodies  >30 publications with TRAF1 and Carcinoma
 Nervous System Diseases Antibodies  >18 publications with TRAF1 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >17 publications with TRAF1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >15 publications with TRAF1 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >14 publications with TRAF1 and Cell Transformation, Neoplastic
 Gastrointestinal Diseases Antibodies  >13 publications with TRAF1 and Gastrointestinal Diseases
 Hematologic Diseases Antibodies  >9 publications with TRAF1 and Hematologic Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >139 publications with TRAF1 and Blood
 Kidney Antibodies  >26 publications with TRAF1 and Kidney
 Skin Antibodies  >16 publications with TRAF1 and Skin
 Brain Antibodies  >16 publications with TRAF1 and Brain
 Lung Antibodies  >13 publications with TRAF1 and Lung
 Lymph Node Antibodies  >12 publications with TRAF1 and Lymph Node
 Lymph Antibodies  >11 publications with TRAF1 and Lymph
 Embryonic Tissue Antibodies  >7 publications with TRAF1 and Embryonic Tissue
 Intestine Antibodies  >6 publications with TRAF1 and Intestine
 Eye Antibodies  >6 publications with TRAF1 and Eye
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