NP_001071122.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,385 Da
NCBI Official Full Name
tumor necrosis factor alpha-induced protein 8 isoform b
NCBI Official Synonym Full Names
TNF alpha induced protein 8
NCBI Official Synonym Symbols
NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13 [Similar Products]
NCBI Protein Information
tumor necrosis factor alpha-induced protein 8
UniProt Protein Name
Tumor necrosis factor alpha-induced protein 8
UniProt Synonym Protein Names
Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1
UniProt Synonym Gene Names
UniProt Entry Name
TFIP8_HUMAN
UniProt Comments for TNFAIP8
TNFAIP8: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. Belongs to the TNFAIP8 family. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 5q23.1
Cellular Component: cytoplasm
Molecular Function: caspase inhibitor activity; protein binding
Biological Process: negative regulation of apoptosis
Research Articles on TNFAIP8
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Diseases associated with anti-TNFAIP8 antibody
Organs/Tissues associated with anti-TNFAIP8 antibody
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