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anti-TNFRSF10B antibody :: Rabbit anti-Human, Mouse TNFRSF10B / Killer / DR5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240830
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TNFRSF10B / Killer / DR5, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human TNFRSF10B / Killer / DR5

 Product Synonym Names    Anti-TNFRSF10B / Killer / DR5 Antibody (C-Terminus) IHC-plus; TNFRSF10B; Cytotoxic TRAIL receptor-2; CD262 antigen; DR5; Death receptor 5; KILLER; TRAIL-R2; TRICK2B; TRAILR2; TRICK2A; TRICKB; TRICK2; CD262; Fas-like protein; TRAIL receptor 2; ZTNFR9; Human TNFRSF10B; Killer; DR5
 Product Gene Name   

anti-TNFRSF10B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 603612
 3D Structure    ModBase 3D Structure for O14763
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    peptide corresponding to amino acids near the carboxy terminus of human DR5 precursor
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    A peptide corresponding to amino acids near the carboxy terminus of human DR5 precursor.
 Immunogen Type    Synthetic peptide
 Immunogen    TNFRSF10B / Killer / DR5 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DR5 precursor.
 Antigen Modification    C-Terminus
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-TNFRSF10B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TNFRSF10B antibody

   Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently.
 Product Categories/Family for anti-TNFRSF10B antibody    Family: TNF Receptor
 Applications Tested/Suitable for anti-TNFRSF10B antibody   

Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB)

 Application Notes for anti-TNFRSF10B antibody    ICC, IHC-P (5 - 10 ug/ml), WB (1:250 - 1:500)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-TNFRSF10B antibody    Anti-DR5 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-TNFRSF10B antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-TNFRSF10B antibody    Immunofluorescence of DR5 in HeLa cells with DR5 antibody at 20 ug/ml.
anti-TNFRSF10B antibody Immunofluorescence (IF) image
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 Immunocytochemistry (ICC) of anti-TNFRSF10B antibody    Immunocytochemistry of DR5 in HeLa cells with DR5 antibody at 5 ug/ml.
anti-TNFRSF10B antibody Immunocytochemistry (ICC) (ICC) image
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 Western Blot (WB) of anti-TNFRSF10B antibody    Western blot of DR5 in HeLa (H) and K562 (K) cell lysates with DR5 antibody at 2 ug/ml.
anti-TNFRSF10B antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TNFRSF10B. It may not necessarily be applicable to this product.
 NCBI GI #    224494019
 NCBI GeneID    8795
 NCBI Accession #    NP_003833.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_003842.4 [Other Products]
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 UniProt Primary Accession #    O14763 [Other Products]
 UniProt Secondary Accession #    O14720; O15508; O15517; O15531; Q6UXM8; Q7Z360; Q9BVE0 [Other Products]
 UniProt Related Accession #    O14763 [Other Products]
 Molecular Weight    45,083 Da
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 10B isoform 1
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 10b
 NCBI Official Symbol    TNFRSF10B [Similar Products]
 NCBI Official Synonym Symbols   
DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 10B; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; TNF receptor superfamily member 10b; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer)
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 10B
 UniProt Synonym Protein Names   
Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD_antigen: CD262
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF10B [Similar Products]
 UniProt Synonym Gene Names    DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; TRAIL receptor 2; TRAIL-R2 [Similar Products]
 UniProt Entry Name    TR10B_HUMAN
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 NCBI Summary for TNFRSF10B    The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for TNFRSF10B    TRAIL-R2: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Homotrimer. Can interact with TRADD and RIPK1. Regulated by p53/TP53. Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p22-p21

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding; TRAIL binding; receptor activity

Biological Process: caspase activation; regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; cell surface receptor linked signal transduction; induction of apoptosis via death domain receptors; apoptosis; activation of NF-kappaB-inducing kinase

Disease: Squamous Cell Carcinoma, Head And Neck
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 Research Articles on TNFRSF10B    1. results provide novel insights into the role of ATF3 as an essential transcription factor for p53-independent DR5 induction upon both ZER and CCB treatment, and this may be a useful biomarker for TRAIL-based anticancer therapy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNFRSF10B antibodyPathways associated with anti-TNFRSF10B antibody
 Reference Product  PubMed Publications
 TNFSF10 antibody  >2783 publications with TNFRSF10B and TNFSF10
 CASP8 antibody  >788 publications with TNFRSF10B and CASP8
 FADD antibody  >421 publications with TNFRSF10B and FADD
 CFLAR antibody  >158 publications with TNFRSF10B and CFLAR
 TRADD antibody  >48 publications with TNFRSF10B and TRADD
 CASP10 antibody  >36 publications with TNFRSF10B and CASP10
 TP53 antibody  >31 publications with TNFRSF10B and TP53
 RIPK1 antibody  >22 publications with TNFRSF10B and RIPK1
 IKBKB antibody  >16 publications with TNFRSF10B and IKBKB
 IKBKG antibody  >1 publications with TNFRSF10B and IKBKG
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Caspase-8 Activation By Cleavage Pathway antibodies  Caspase-8 Activation By Cleavage Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
Diseases associated with anti-TNFRSF10B antibodyOrgans/Tissues associated with anti-TNFRSF10B antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2070 publications with TNFRSF10B and Necrosis
 Leukemia Antibodies  >254 publications with TNFRSF10B and Leukemia
 Liver Diseases Antibodies  >166 publications with TNFRSF10B and Liver Diseases
 Breast Neoplasms Antibodies  >164 publications with TNFRSF10B and Breast Neoplasms
 Lung Neoplasms Antibodies  >154 publications with TNFRSF10B and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >150 publications with TNFRSF10B and Neoplasms, Experimental
 Lung Diseases Antibodies  >145 publications with TNFRSF10B and Lung Diseases
 Colonic Neoplasms Antibodies  >141 publications with TNFRSF10B and Colonic Neoplasms
 Inflammation Antibodies  >136 publications with TNFRSF10B and Inflammation
 Carcinoma, Hepatocellular Antibodies  >114 publications with TNFRSF10B and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >484 publications with TNFRSF10B and Blood
 Liver Antibodies  >221 publications with TNFRSF10B and Liver
 Lung Antibodies  >205 publications with TNFRSF10B and Lung
 Prostate Antibodies  >163 publications with TNFRSF10B and Prostate
 Brain Antibodies  >107 publications with TNFRSF10B and Brain
 Vascular Antibodies  >79 publications with TNFRSF10B and Vascular
 Kidney Antibodies  >76 publications with TNFRSF10B and Kidney
 Skin Antibodies  >65 publications with TNFRSF10B and Skin
 Bone Marrow Antibodies  >59 publications with TNFRSF10B and Bone Marrow
 Muscle Antibodies  >37 publications with TNFRSF10B and Muscle
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