NP_001183.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 17
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 17
NCBI Protein Information
tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 17
UniProt Synonym Protein Names
B-cell maturation protein
UniProt Synonym Gene Names
UniProt Entry Name
TNR17_HUMAN
NCBI Summary for TNFRSF17
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
UniProt Comments for TNFRSF17
TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
Protein type: Membrane protein, integral; Oncoprotein; Receptor, misc.
Chromosomal Location of Human Ortholog: 16p13.1
Cellular Component: integral to membrane; plasma membrane; endomembrane system
Molecular Function: receptor activity
Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction
Research Articles on TNFRSF17
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Products associated with anti-TNFRSF17 antibody
Pathways associated with anti-TNFRSF17 antibody
Diseases associated with anti-TNFRSF17 antibody
Organs/Tissues associated with anti-TNFRSF17 antibody
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