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anti-TOMM70A antibody :: Rabbit TOM70 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150544
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TOM70 (TOMM70A), Polyclonal Antibody

★Popular Item★
 Also Known As   

TOM70 Antibody

 Product Synonym Names    TOM70; KIAA0719; TOM70; Mitochondrial import receptor subunit TOM70; Mitochondrial precursor proteins import receptor; translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
 Product Gene Name   

anti-TOMM70A antibody

[Similar Products]
 Antibody/Peptide Pairs    TOM70 peptide (MBS152688) is used for blocking the activity of TOM70 antibody (MBS150544)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606081
 3D Structure    ModBase 3D Structure for O94826
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    TOM70 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    TOM70 antibody was raised against a 15 amino acid synthetic peptide near the center of human TOM70.
 Buffer    TOM70 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    TOM70 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-TOMM70A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TOMM70A antibody

   TOM70 Antibody: The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. TOM70, an important member of the TOM complex, contains a tetratricopeptide repeat domain similar to those found in cytosolic chaperones such as Hsp90 and Hsc70 and provides a docking site for these proteins. This interaction is thought to be a critical first step in the TOM70-dependent mitochondrial import, followed by contact between the preprotein and TOM70. After targeting to TOM70, preproteins are translocated through the outer membrane via the TOM40 import pore complex. The precise mechanism of how preproteins progress from TOM70 to TOM40 to full translocation is still unclear. At least two isoforms of TOM70 are known to exist.
 Applications Tested/Suitable for anti-TOMM70A antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-TOMM70A antibody    TOM70 antibody can be used for detection of TOM70 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-TOMM70A antibody    Western blot analysis of TOM70 in rat brain tissue lysate with TOM70 antibody at (A) 1 and (B) 2 μg/mL.
anti-TOMM70A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TOMM70A antibody    Immunohistochemistry of TOM70 in mouse brain tissue with TOM70 antibody at 2.5 μg/mL.
anti-TOMM70A antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-TOMM70A antibody    Immunofluorescence of TOM70 in Mouse Brain cells with TOM70 antibody at 20 μg/mL.
anti-TOMM70A antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for TOMM70A. It may not necessarily be applicable to this product.
 NCBI GI #    54607135
 NCBI GeneID    9868
 NCBI Accession #    NP_055635 [Other Products]
 NCBI GenBank Nucleotide #    NM_014820.4 [Other Products]
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 UniProt Primary Accession #    O94826 [Other Products]
 UniProt Secondary Accession #    D3DN48 [Other Products]
 UniProt Related Accession #    O94826 [Other Products]
 Molecular Weight    67,455 Da
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 NCBI Official Full Name    mitochondrial import receptor subunit TOM70
 NCBI Official Synonym Full Names    translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
 NCBI Official Symbol    TOMM70A [Similar Products]
 NCBI Protein Information    mitochondrial import receptor subunit TOM70; translocase of outer membrane 70 kDa subunit; mitochondrial precursor proteins import receptor
 UniProt Protein Name    Mitochondrial import receptor subunit TOM70
 UniProt Synonym Protein Names   
Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit
 UniProt Gene Name    TOMM70A [Similar Products]
 UniProt Synonym Gene Names    KIAA0719; TOM70 [Similar Products]
 UniProt Entry Name    TOM70_HUMAN
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 NCBI Summary for TOMM70A    This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. [provided by RefSeq, Oct 2011]
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 UniProt Comments for TOMM70A    TOMM70A: Receptor that accelerates the import of all mitochondrial precursor proteins. Belongs to the Tom70 family.

Protein type: Receptor, protein translocating; Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q12.2

Cellular Component: mitochondrial outer membrane translocase complex; mitochondrion; membrane; integral to membrane

Molecular Function: protein binding; protein transmembrane transporter activity

Biological Process: cellular protein metabolic process; protein targeting to mitochondrion
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 Research Articles on TOMM70A    1. Blockade of mitochondrial protein import triggers the recruitment of PARK2, by PINK1, to the TOMM machinery.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TOMM70A antibodyPathways associated with anti-TOMM70A antibody
 Reference Product  PubMed Publications
 TIMM9 antibody  >1 publications with TOMM70A and TIMM9
 TOMM40 antibody  >1 publications with TOMM70A and TOMM40
 TOMM20 antibody  >1 publications with TOMM70A and TOMM20
 TOMM22 antibody  >1 publications with TOMM70A and TOMM22
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mitochondrial Protein Import Pathway antibodies  Mitochondrial Protein Import Pathway Diagram
Diseases associated with anti-TOMM70A antibodyOrgans/Tissues associated with anti-TOMM70A antibody
 Disease Name  Pubmed Publications
 Movement Disorders Antibodies  >1 publications with TOMM70A and Movement Disorders
 Liver Diseases Antibodies  >1 publications with TOMM70A and Liver Diseases
 Necrosis Antibodies  >1 publications with TOMM70A and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with TOMM70A and Liver
 Brain Antibodies  >2 publications with TOMM70A and Brain
 Prostate Antibodies  >1 publications with TOMM70A and Prostate
 Thyroid Antibodies  >1 publications with TOMM70A and Thyroid
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