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anti-TOSO antibody :: Rabbit TOSO Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS221472
Testing Data #1
Unit / Price
0.1 mg  /  $325 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TOSO, Polyclonal Antibody

★Popular Item★
 Also Known As   

RABBIT ANTI HUMAN TOSO (C-TERMINAL)

 Product Gene Name   

anti-TOSO antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606015
 3D Structure    ModBase 3D Structure for O60667
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse (Expected from Sequence), Rat (Expected from Sequence)
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 Specificity    This item detects an epitope within the C-terminal (CT) region of human Toso, also known as Fas Apoptotic Inhibitory Molecule 3 (FAIM3). Toso is expressed by lymphoid and haematopoietic cells and is up-regulated by T-cell activation. Toso expressing cells have increased resistance to Fas-, FADD-, and TNFalpha-induced apoptosis. Toso is membrane bound, and is thought to directly bind to FADD, disrupting DISC formation and thus inhibiting caspase-8 activation.

Toso is a potential proto-oncogene, and could be a therapeutic target for use in the treatment of autoimmune diseases. Despite its predicted molecular weight, Toso often migrates at 60kDa in SDS PAGE.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 0.5 mg/ml (lot specific)
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 Perservative Stabilisers    0.02% Sodium Azide
 Immunogen    A 13 amino acid peptide from near the carboxy terminus of human Toso.
Buffer Solution
 Antiserum Preparation    Antisera to human Toso were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-TOSO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TOSO antibody

   MBS221472 detects an epitope within the C-terminal (CT) region of human Toso, also known as Fas Apoptotic Inhibitory Molecule 3 (FAIM3). Toso is expressed by lymphoid and haematopoietic cells and is up-regulated by T-cell activation. Toso expressing cells have increased resistance to Fas-, FADD-, and TNFalpha-induced apoptosis. Toso is membrane bound, and is thought to directly bind to FADD, disrupting DISC formation and thus inhibiting caspase-8 activation. Toso is a potential proto-oncogene, and could be a therapeutic target for use in the treatment of autoimmune diseases. Despite its predicted molecular weight, Toso often migrates at 60kDa in SDS PAGE.
 Applications Tested/Suitable for anti-TOSO antibody   

Western Blot (WB)

 Application Notes for anti-TOSO antibody    Western Blot: This item detects a band of approximately 43kDa in human lung tissue lysate.
Western Blotting: Minimum Dilution: 1; Maximum Dilution: 2ug/ml
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 Testing Data #1 of anti-TOSO antibody    Western blot analysis of human lung lysate probed with Rabbit anti Human TOSO (MBS221472)
anti-TOSO antibody Testing Data #1 image
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NCBI/Uniprot data below describe general gene information for TOSO. It may not necessarily be applicable to this product.
 NCBI GI #    216547554
 NCBI GeneID    9214
 NCBI Accession #    NP_001135945.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001142473.1 [Other Products]
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 UniProt Primary Accession #    O60667 [Other Products]
 UniProt Secondary Accession #    A8K7J2; B7Z6Z0; D9MWM3 [Other Products]
 UniProt Related Accession #    O60667 [Other Products]
 Molecular Weight    33,828 Da
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 NCBI Official Full Name    fas apoptotic inhibitory molecule 3 isoform b
 NCBI Official Synonym Full Names    Fas apoptotic inhibitory molecule 3
 NCBI Official Symbol    FAIM3 [Similar Products]
 NCBI Official Synonym Symbols   
FCMR; TOSO
[Similar Products]
 NCBI Protein Information    fas apoptotic inhibitory molecule 3; Fc mu receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso
 UniProt Protein Name    Fas apoptotic inhibitory molecule 3
 UniProt Synonym Protein Names   
Regulator of Fas-induced apoptosis Toso
 UniProt Gene Name    FAIM3 [Similar Products]
 UniProt Synonym Gene Names    TOSO [Similar Products]
 UniProt Entry Name    FAIM3_HUMAN
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 NCBI Summary for TOSO    Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
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 UniProt Comments for TOSO    FAIM3: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: extracellular region; integral to membrane

Biological Process: immune system process; cellular defense response; negative regulation of apoptosis
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 Research Articles on TOSO    1. Overexpression of TOSO gene is associated with chronic lymphocytic leukemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TOSO antibodyDiseases associated with anti-TOSO antibody
 Reference Product  PubMed Publications
 CD19 antibody  >1 publications with TOSO and CD19
 Disease Name  Pubmed Publications
 Demyelinating Diseases Antibodies  >1 publications with TOSO and Demyelinating Diseases
 Disease Models, Animal Antibodies  >1 publications with TOSO and Disease Models, Animal
 Liver Diseases Antibodies  >1 publications with TOSO and Liver Diseases
 Inflammation Antibodies  >1 publications with TOSO and Inflammation
 Necrosis Antibodies  >1 publications with TOSO and Necrosis
Organs/Tissues associated with anti-TOSO antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with TOSO and Blood
 Liver Antibodies  >1 publications with TOSO and Liver
 Placenta Antibodies  >1 publications with TOSO and Placenta
 Spleen Antibodies  >1 publications with TOSO and Spleen
 Lung Antibodies  >1 publications with TOSO and Lung
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