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anti-TOX3 antibody :: Rabbit anti-Human, Mouse TOX3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7046650
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TOX3, Polyclonal Antibody

★Popular Item★
 Also Known As   

TOX3 Antibody

 Product Synonym Names    TOX high mobility group box family member 3; CAG trinucleotide repeat-containing gene F9 protein; Trinucleotide repeat-containing gene 9 protein; TOX3; CAGF9; TNRC9
 Product Gene Name   

anti-TOX3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    611416
 3D Structure    ModBase 3D Structure for O15405
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human TOX high mobility group box family member 3 protein
 Conjugate    Non-conjugated
 Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TOX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TOX3 antibody

   Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.
 Applications Tested/Suitable for anti-TOX3 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Western Blot (WB) of anti-TOX3 antibody    Western blot
All lanes: TOX3 antibody at 9 ug/ml
Lane 1: Mouse heart tissue
Lane 2: Mouse spleen tissue
Lane 3: Mouse brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 63 kDa
Observed band size: 63,24 kDa

anti-TOX3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TOX3 antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS7046650 at dilution of 1:100
anti-TOX3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TOX3 antibody    Immunofluorescent analysis of HepG-2 cells using MBS7046650 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-TOX3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TOX3. It may not necessarily be applicable to this product.
 NCBI GI #    226054295
 NCBI GeneID    27324
 NCBI Accession #    NP_001073899.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001080430.3 [Other Products]
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 UniProt Primary Accession #    O15405 [Other Products]
 UniProt Secondary Accession #    B4DRD0; B5MCW4 [Other Products]
 UniProt Related Accession #    O15405 [Other Products]
 Molecular Weight    63,100 Da
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 NCBI Official Full Name    TOX high mobility group box family member 3 isoform 1
 NCBI Official Synonym Full Names    TOX high mobility group box family member 3
 NCBI Official Symbol    TOX3 [Similar Products]
 NCBI Official Synonym Symbols   
CAGF9; TNRC9
[Similar Products]
 NCBI Protein Information    TOX high mobility group box family member 3
 UniProt Protein Name    TOX high mobility group box family member 3
 UniProt Synonym Protein Names   
CAG trinucleotide repeat-containing gene F9 protein; Trinucleotide repeat-containing gene 9 protein
 Protein Family    TOX high mobility group box family
 UniProt Gene Name    TOX3 [Similar Products]
 UniProt Synonym Gene Names    CAGF9; TNRC9 [Similar Products]
 UniProt Entry Name    TOX3_HUMAN
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 NCBI Summary for TOX3    The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
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 UniProt Comments for TOX3    TOX3: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 16q12.1

Molecular Function: chromatin binding; estrogen response element binding; phosphoprotein binding; protein binding; protein homodimerization activity

Biological Process: negative regulation of neuron apoptosis; positive regulation of transcription, DNA-dependent
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 Research Articles on TOX3    1. The TOX3 SNPs rs3803662 C > T, rs12443621 A > G and rs8051542 C > T were all correlated with increased risk of breast cancer in the European and Asian populations, but not in the African one.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TOX3 antibodyDiseases associated with anti-TOX3 antibody
 Reference Product  PubMed Publications
 FGFR2 antibody  >32 publications with TOX3 and FGFR2
 MAP3K1 antibody  >18 publications with TOX3 and MAP3K1
 LSP1 antibody  >18 publications with TOX3 and LSP1
 MRPS30 antibody  >6 publications with TOX3 and MRPS30
 RAD51B antibody  >2 publications with TOX3 and RAD51B
 FOS antibody  >1 publications with TOX3 and FOS
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >53 publications with TOX3 and Breast Neoplasms
 Breast Neoplasms, Male Antibodies  >9 publications with TOX3 and Breast Neoplasms, Male
 Nervous System Diseases Antibodies  >6 publications with TOX3 and Nervous System Diseases
 Lung Neoplasms Antibodies  >3 publications with TOX3 and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >2 publications with TOX3 and Ovarian Neoplasms
 Disease Models, Animal Antibodies  >2 publications with TOX3 and Disease Models, Animal
 Inflammation Antibodies  >2 publications with TOX3 and Inflammation
 Hypertension Antibodies  >1 publications with TOX3 and Hypertension
 Nerve Degeneration Antibodies  >1 publications with TOX3 and Nerve Degeneration
 Kidney Diseases Antibodies  >1 publications with TOX3 and Kidney Diseases
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