NP_775489.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tryptophan 5-hydroxylase 2
NCBI Official Synonym Full Names
tryptophan hydroxylase 2
NCBI Official Synonym Symbols
NCBI Protein Information
tryptophan 5-hydroxylase 2
UniProt Protein Name
Tryptophan 5-hydroxylase 2
UniProt Synonym Protein Names
Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2
UniProt Synonym Gene Names
UniProt Entry Name
TPH2_HUMAN
NCBI Summary for TPH2
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Jul 2008]
UniProt Comments for TPH2
TPH2: an enzyme that is rate-limiting in the biosynthesis of serotonin. It catalyzes the biopterin dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Its expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells. Two alternatively spliced isoforms have been described. Isoform 2 appears to be expressed exclusively in the brain, and is expressed at significantly higher levels in the raphe nuclei than isoform 1.
Protein type: Oxidoreductase; Amino Acid Metabolism - tryptophan; EC 1.14.16.4
Chromosomal Location of Human Ortholog: 12q21.1
Cellular Component: neuron projection; cytosol
Molecular Function: amino acid binding; tryptophan 5-monooxygenase activity; iron ion binding
Biological Process: circadian rhythm; response to nutrient levels; response to estrogen stimulus; indolalkylamine biosynthetic process; aromatic amino acid family metabolic process; response to glucocorticoid stimulus; response to activity; response to calcium ion; serotonin biosynthetic process
Disease: Major Depressive Disorder; Attention Deficit-hyperactivity Disorder, Susceptibility To, 7
Product References and Citations for anti-TPH2 antibody
Khatua,A.K., et.al., Virology 400 (1), 68-75 (2010) Koning,F.A., et.al., J. Virol. 83 (18), 9474-9485 (2009)
Research Articles on TPH2
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Products associated with anti-TPH2 antibody
Pathways associated with anti-TPH2 antibody
Diseases associated with anti-TPH2 antibody
Organs/Tissues associated with anti-TPH2 antibody
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