NP_001036816.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 33 kDa Predicted: 33 kDa
NCBI Official Full Name
tropomyosin alpha-3 chain isoform Tpm3.2cy
NCBI Official Synonym Full Names
tropomyosin 3
NCBI Official Synonym Symbols
TM3; TM5; TRK; CFTD; NEM1; TM-5; TM30; CAPM1; TM30nm; TPM3nu; TPMsk3; hscp30; HEL-189; HEL-S-82p; OK/SW-cl.5 [Similar Products]
NCBI Protein Information
tropomyosin alpha-3 chain
UniProt Protein Name
Tropomyosin alpha-3 chain
UniProt Synonym Protein Names
Gamma-tropomyosin; Tropomyosin-3; Tropomyosin-5; hTM5
UniProt Synonym Gene Names
NCBI Summary for TPM3
This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
UniProt Comments for TPM3
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Research Articles on TPM3
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Products associated with anti-TPM3 antibody
Pathways associated with anti-TPM3 antibody
Diseases associated with anti-TPM3 antibody
Organs/Tissues associated with anti-TPM3 antibody
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