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anti-TPPP antibody :: Goat TPPP/p25 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422281
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TPPP/p25, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-TPPP/p25 Antibody

 Product Synonym Names    brain specific protein p25 alpha, glycogen synthase kinase 3 (GSK3) inhibitor p24, p24, p25, p25alpha, TPPP/p25, TPPP1, tubulin polymerization promoting protein, tubulin polymerization-promoting protein, TPPP
 Product Gene Name   

anti-TPPP antibody

[Similar Products]
 Product Synonym Gene Name    p25 [Similar Products]
 Antibody/Peptide Pairs    TPPP/p25 peptide (MBS427274) is used for blocking the activity of TPPP/p25 antibody (MBS422281)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DPSKDRAAKR LSLES
 OMIM    608773
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse, Rat

Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-DPSKDRAAKRLSLES, from the internal region of the protein sequence according to NP_008961.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-TPPP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TPPP antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TPPP antibody    Peptide ELISA: antibody detection limit dilution 1:32000.
Western blot: Approx 26kDa band observed in Human Brain (Cerebellum), Mouse and Rat Brain lysates (calculated MW of 23.7kDa according to NP_008961.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Acevedo et al, Exp Cell Res. 2007 Dec 10;313(20):4091-106; PMID: 18028908). Recommended concentration: 0.001-0.01ug/ml. Primary incubation was 1 hour. An additional band of unknown identity was also consistently observed at 17kDa. This band was successfully blocked by incubation with the immunizing peptide.
IHC: In paraffin embedded Human Cerebellum shows strong staining of axonal bundles through the granular layer. Recommended concentration: 1-2ug/ml. Paraffin embedded Human Cortex. Recommended concentration: 3.75ug/ml.
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 Western Blot (WB) of anti-TPPP antibody    (0. 001ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-TPPP antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-TPPP antibody    (0. 001ug/ml) staining of Mouse (A) and Rat (B) Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence
anti-TPPP antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TPPP antibody    (2ug/ml) staining of paraffin embedded Human Cerebellum. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.
anti-TPPP antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry of anti-TPPP antibody    Negative Control showing staining of paraffin embedded Human Cerebellum, with no primary antibody.
anti-TPPP antibody Immunohistochemistry (IHC) image
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 Immunohistochemistry of anti-TPPP antibody    (3.75ug/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-TPPP antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for TPPP. It may not necessarily be applicable to this product.
 NCBI GI #    5902018
 NCBI GeneID    11076
 NCBI Accession #    NP_008961.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007030.2 [Other Products]
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 UniProt Related Accession #    O94811 [Other Products]
 Molecular Weight    23,694 Da
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 NCBI Official Full Name    tubulin polymerization-promoting protein
 NCBI Official Synonym Full Names    tubulin polymerization promoting protein
 NCBI Official Symbol    TPPP [Similar Products]
 NCBI Official Synonym Symbols   
p24; p25; TPPP1; TPPP/p25; p25alpha
[Similar Products]
 NCBI Protein Information    tubulin polymerization-promoting protein
 UniProt Protein Name    Tubulin polymerization-promoting protein
 UniProt Synonym Protein Names   
25 kDa brain-specific protein; TPPP/p25; p24; p25-alpha
 Protein Family    Tubulin polymerization-promoting protein
 UniProt Gene Name    TPPP [Similar Products]
 UniProt Synonym Gene Names    TPPP1; TPPP [Similar Products]
 UniProt Entry Name    TPPP_HUMAN
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 UniProt Comments for TPPP    TPPP: May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. Belongs to the TPPP family.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 5p15.3

Cellular Component: cytoplasm; microtubule; myelin sheath; nucleus; perinuclear region of cytoplasm

Molecular Function: microtubule binding; protein binding; tubulin binding

Biological Process: microtubule bundle formation; microtubule polymerization; positive regulation of protein complex assembly; positive regulation of protein polymerization
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 Research Articles on TPPP    1. Epigenetic changes in TPPP, in combination with experiences of maltreatment, may confer risk for depression in children.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TPPP antibodyPathways associated with anti-TPPP antibody
 Reference Product  PubMed Publications
 SNCA antibody  >4 publications with TPPP and SNCA
 LIMK1 antibody  >2 publications with TPPP and LIMK1
 GAPDH antibody  >1 publications with TPPP and GAPDH
 ROCK1 antibody  >1 publications with TPPP and ROCK1
 Products by Pathway  Pathway Diagram
 Glial Cell Differentiation Pathway antibodies  Glial Cell Differentiation Pathway Diagram
 Regulation Of Microtubule Cytoskeleton Pathway antibodies  Regulation Of Microtubule Cytoskeleton Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
Diseases associated with anti-TPPP antibodyOrgans/Tissues associated with anti-TPPP antibody
 Disease Name  Pubmed Publications
 Atrophy Antibodies  >11 publications with TPPP and Atrophy
 Mental Disorders Antibodies  >3 publications with TPPP and Mental Disorders
 Nervous System Malformations Antibodies  >2 publications with TPPP and Nervous System Malformations
 Neurobehavioral Manifestations Antibodies  >2 publications with TPPP and Neurobehavioral Manifestations
 Memory Disorders Antibodies  >1 publications with TPPP and Memory Disorders
 Neoplasm Metastasis Antibodies  >1 publications with TPPP and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >1 publications with TPPP and Neoplasms, Experimental
 Necrosis Antibodies  >1 publications with TPPP and Necrosis
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with TPPP and Prenatal Exposure Delayed Effects
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >47 publications with TPPP and Nerve
 Brain Antibodies  >41 publications with TPPP and Brain
 Blood Antibodies  >2 publications with TPPP and Blood
 Lung Antibodies  >2 publications with TPPP and Lung
 Pancreas Antibodies  >1 publications with TPPP and Pancreas
 Skin Antibodies  >1 publications with TPPP and Skin
 Kidney Antibodies  >1 publications with TPPP and Kidney
 Intestine Antibodies  >1 publications with TPPP and Intestine
 Ovary Antibodies  >1 publications with TPPP and Ovary
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