NP_003780.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tumor necrosis factor receptor type 1-associated DEATH domain protein
NCBI Official Synonym Full Names
TNFRSF1A-associated via death domain
NCBI Official Synonym Symbols
NCBI Protein Information
tumor necrosis factor receptor type 1-associated DEATH domain protein; TNFR1-associated death domain protein; tumor necrosis factor receptor type 1 associated death domain protein; tumor necrosis factor receptor-1-associated protein
UniProt Protein Name
Tumor necrosis factor receptor type 1-associated DEATH domain protein
UniProt Synonym Protein Names
TNFRSF1A-associated via death domain
UniProt Synonym Gene Names
UniProt Entry Name
TRADD_HUMAN
NCBI Summary for TRADD
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]
UniProt Comments for TRADD
TRADD: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP. Found in all examined tissues.
Protein type: Apoptosis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 16q22
Cellular Component: cytoskeleton; cytoplasm; cytosol; nucleus; receptor complex; lipid raft
Molecular Function: identical protein binding; protein binding; signal transducer activity; protein complex binding; tumor necrosis factor receptor binding; kinase binding; molecular adaptor activity
Biological Process: positive regulation of hair follicle development; caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; induction of apoptosis via death domain receptors; tumor necrosis factor-mediated signaling pathway; protein heterooligomerization; positive regulation of apoptosis; apoptosis; signal transduction; activation of NF-kappaB transcription factor
Research Articles on TRADD
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Products associated with anti-TRADD antibody
Pathways associated with anti-TRADD antibody
Diseases associated with anti-TRADD antibody
Organs/Tissues associated with anti-TRADD antibody
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