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anti-TRAF4 antibody :: Rabbit TRAF4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7605152 (SPECIAL PROMOTIONAL PRICING for a limited time) anti-TRAF4 antibody
Unit / Price
0.1 mg  /  $180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRAF4, Polyclonal Antibody

 Also Known As   

TRAF4 Rabbit Polyclonal

 Product Gene Name   

anti-TRAF4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602464
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    >=95% as determined by SDS-PAGE
Immunogen Affinity Purified
 Form/Format    Liquid
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 Immunogen    TNF receptor-associated factor 4
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 Preparation and Storage    PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TRAF4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TRAF4 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for TRAF4. It may not necessarily be applicable to this product.
 NCBI GI #    22027622
 NCBI GeneID    9618
 NCBI Accession #    NP_004286.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004295.3 [Other Products]
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 UniProt Secondary Accession #    O75615; Q14848; Q2KJU4; Q2PJN8 [Other Products]
 UniProt Related Accession #    Q9BUZ4 [Other Products]
 Molecular Weight    22,841 Da
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 NCBI Official Full Name    TNF receptor-associated factor 4
 NCBI Official Synonym Full Names    TNF receptor associated factor 4
 NCBI Official Symbol    TRAF4 [Similar Products]
 NCBI Official Synonym Symbols   
CART1; MLN62; RNF83
[Similar Products]
 NCBI Protein Information    TNF receptor-associated factor 4
 UniProt Protein Name    TNF receptor-associated factor 4
 UniProt Synonym Protein Names   
Cysteine-rich domain associated with RING and Traf domains protein 1; Metastatic lymph node gene 62 protein; MLN 62; RING finger protein 83
 Protein Family    TNF receptor-associated factor
 UniProt Gene Name    TRAF4 [Similar Products]
 UniProt Synonym Gene Names    CART1; MLN62; RNF83; MLN 62 [Similar Products]
 UniProt Entry Name    TRAF4_HUMAN
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 NCBI Summary for TRAF4    This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TRAF4    TRAF4: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Belongs to the TNF receptor-associated factor family. B subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; DNA-binding

Chromosomal Location of Human Ortholog: 17q11-q12

Cellular Component: cytoplasm; cytoskeleton; nucleus; perinuclear region of cytoplasm; plasma membrane; tight junction

Molecular Function: DNA binding; protein binding; protein kinase binding; thioesterase binding; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; WW domain binding; zinc ion binding

Biological Process: activation of NF-kappaB-inducing kinase; apoptosis; positive regulation of JNK cascade; positive regulation of protein kinase activity; protein ubiquitination; regulation of apoptosis; respiratory gaseous exchange; respiratory tube development; signal transduction
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 Research Articles on TRAF4    1. The TRAF4-ERK5 is a dominant pathway in human skin squamous cell carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TRAF4 antibodyPathways associated with anti-TRAF4 antibody
 Reference Product  PubMed Publications
 TRAF6 antibody  >28 publications with TRAF4 and TRAF6
 SMURF1 antibody  >3 publications with TRAF4 and SMURF1
 NOD2 antibody  >3 publications with TRAF4 and NOD2
 TGFB1I1 antibody  >3 publications with TRAF4 and TGFB1I1
 USP7 antibody  >2 publications with TRAF4 and USP7
 MAP3K4 antibody  >1 publications with TRAF4 and MAP3K4
 NGFR antibody  >1 publications with TRAF4 and NGFR
 Products by Pathway  Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Small Cell Lung Cancer Pathway antibodies  Small Cell Lung Cancer Pathway Diagram
 Small Cell Lung Cancer Pathway antibodies  Small Cell Lung Cancer Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
Diseases associated with anti-TRAF4 antibodyOrgans/Tissues associated with anti-TRAF4 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >88 publications with TRAF4 and Necrosis
 Breast Neoplasms Antibodies  >26 publications with TRAF4 and Breast Neoplasms
 Nervous System Diseases Antibodies  >8 publications with TRAF4 and Nervous System Diseases
 Inflammation Antibodies  >8 publications with TRAF4 and Inflammation
 Lung Neoplasms Antibodies  >5 publications with TRAF4 and Lung Neoplasms
 Disease Models, Animal Antibodies  >5 publications with TRAF4 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >4 publications with TRAF4 and Neoplasm Metastasis
 Liver Diseases Antibodies  >2 publications with TRAF4 and Liver Diseases
 Kidney Diseases Antibodies  >2 publications with TRAF4 and Kidney Diseases
 Prostatic Neoplasms Antibodies  >2 publications with TRAF4 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >17 publications with TRAF4 and Blood
 Bone Antibodies  >10 publications with TRAF4 and Bone
 Lung Antibodies  >8 publications with TRAF4 and Lung
 Vascular Antibodies  >7 publications with TRAF4 and Vascular
 Nerve Antibodies  >7 publications with TRAF4 and Nerve
 Liver Antibodies  >4 publications with TRAF4 and Liver
 Connective Tissue Antibodies  >4 publications with TRAF4 and Connective Tissue
 Lymph Node Antibodies  >4 publications with TRAF4 and Lymph Node
 Lymph Antibodies  >4 publications with TRAF4 and Lymph
 Kidney Antibodies  >4 publications with TRAF4 and Kidney
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