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anti-TREM2 antibody :: Goat anti-Mouse TREM-2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS622648 anti-TREM2 antibody
Unit / Price
0.1 mg  /  $560 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TREM-2 (TREM2), Polyclonal Antibody

 Also Known As   

TREM-2 (Trem2, Triggering Receptor Expressed on Monocytes 2)

 Product Synonym Names    Anti -TREM-2 (Trem2, Triggering Receptor Expressed on Monocytes 2)
 Product Gene Name   

anti-TREM2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (41126246..41130922, complement). Location: 6p21.1
 3D Structure    ModBase 3D Structure for Q5TCX1
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Mouse
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 Specificity    Recognizes mouse TREM2. Sequence homology: rat.
 Purity/Purification    Affinity Purified
Purified by affinity chromatography.
 Form/Format    Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
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 Immunogen    Synthetic peptide corresponding to C-QVEHSTSRNQET, from the internal region of mouse TREM2 (NP_112544.1).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-TREM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TREM2 antibody

   TREM-2 (Triggering Receptor Expressed by Myeloid cells) is an Ig superfamily cell surface receptor that activates a number of myeloid cell types. It is a member of a small gene family located on human chromosome 6p21 and mouse chromosome 17 in a region linked to the MHC. A single human TREM-2 gene has been described, however, two closely related orthologs were reported in mouse. The proteins differ by only three amino acids and were designated TREM-2a and TREM-2b. TREM-2 is type I transmembrane protein consisting of a single extracellular immunoglobulin (V-like) domain, a transmembrane domain with a positively charged lysine residue, and a short cytoplasmic tail. It associates with the signal adapter protein, DAP12, for signaling and function. DAP12 has a cytoplasmic ITAM that is phosphorylated upon ligand binding leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM-2 is expressed by immature monocyte-derived dendritic cells (DC), and expression is down-regulated upon activation of DC by microbial products and costimulatory signals. Ligation of TREM-2 on immature DC with anti-TREM-2 antibodies results in partial DC activation and the up-regulation of CCR7 and some co-stimulatory molecules. A role for TREM-2 in the functioning of osteoclasts and microglia is suggested by the discovery that homozygous loss-of-function mutations in either TREM-2 or DAP12 result in Nasu-Hakola disease characterized by a combination of presenile demetia and bone cysts. In vitro studies indicate that the differentiation of myeloid precursors into osteoclasts is dramatically impaired in TREM-2 deficient individuals.
 Product Categories/Family for anti-TREM2 antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-TREM2 antibody   

Western Blot (WB)

 Application Notes for anti-TREM2 antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:16,000
Western Blot: 0.3-1ug/ml detects an ~28kDa band observed in Mouse Liver lysates (calculated MW of 24.5kDa according to NP_112544.1).
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NCBI/Uniprot data below describe general gene information for TREM2. It may not necessarily be applicable to this product.
 NCBI GI #    9507203
 NCBI GeneID    54209
 NCBI Accession #    NP_061838.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_018965.2 [Other Products]
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 UniProt Primary Accession #    Q5TCX1 [Other Products]
 UniProt Secondary Accession #    A6NDG2 [Other Products]
 UniProt Related Accession #    Q5TCX0; Q5TCX1; Q9NZC2 [Other Products]
 Molecular Weight    25,447 Da [Similar Products]
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 NCBI Official Full Name    triggering receptor expressed on myeloid cells 2
 NCBI Official Synonym Full Names    triggering receptor expressed on myeloid cells 2
 NCBI Official Symbol    TREM2 [Similar Products]
 NCBI Official Synonym Symbols   
TREM-2; Trem2a; Trem2b; Trem2c
[Similar Products]
 NCBI Protein Information    triggering receptor expressed on myeloid cells 2; OTTHUMP00000016368; OTTHUMP00000016369; triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2a
 UniProt Protein Name    Triggering receptor expressed on myeloid cells 2
 Protein Family    Triggering receptor expressed on myeloid cells
 UniProt Gene Name    TREM2 [Similar Products]
 UniProt Entry Name    Q5TCX1_HUMAN
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 NCBI Summary for TREM2    The protein encoded by this gene is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). [provided by RefSeq]
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 UniProt Comments for TREM2    TREM2: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: intracellular membrane-bound organelle; plasma membrane; integral to membrane; extracellular region

Molecular Function: peptidoglycan binding; lipopolysaccharide binding; receptor activity

Biological Process: axon guidance; positive regulation of peptidyl-tyrosine phosphorylation; detection of lipopolysaccharide; detection of peptidoglycan; innate immune response; positive regulation of calcium-mediated signaling; humoral immune response; positive regulation of antigen processing and presentation of peptide antigen via MHC class II

Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
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 Research Articles on TREM2    1. Mutations in TREM2 lead to pure early-onset dementia without bone cysts
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TREM2 antibodyPathways associated with anti-TREM2 antibody
 Reference Product  PubMed Publications
 TYROBP antibody  >35 publications with TREM2 and TYROBP
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Other Semaphorin Interactions Pathway antibodies  Other Semaphorin Interactions Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram
Diseases associated with anti-TREM2 antibodyOrgans/Tissues associated with anti-TREM2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >25 publications with TREM2 and Inflammation
 Dementia Antibodies  >24 publications with TREM2 and Dementia
 Neoplasms Antibodies  >12 publications with TREM2 and Neoplasms
 Necrosis Antibodies  >8 publications with TREM2 and Necrosis
 Neurodegenerative Diseases Antibodies  >7 publications with TREM2 and Neurodegenerative Diseases
 Demyelinating Diseases Antibodies  >7 publications with TREM2 and Demyelinating Diseases
 Bone Diseases, Developmental Antibodies  >5 publications with TREM2 and Bone Diseases, Developmental
 Arteriosclerosis Antibodies  >3 publications with TREM2 and Arteriosclerosis
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >3 publications with TREM2 and Encephalomyelitis, Autoimmune, Experimental
 Melanoma, Experimental Antibodies  >1 publications with TREM2 and Melanoma, Experimental
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >25 publications with TREM2 and Brain
 Lung Antibodies  >8 publications with TREM2 and Lung
 Ovary Antibodies  >2 publications with TREM2 and Ovary
 Kidney Antibodies  >1 publications with TREM2 and Kidney
 Adipose Tissue Antibodies  >1 publications with TREM2 and Adipose Tissue
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