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anti-TREM2 antibody :: Goat TREM2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420713
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TREM2, Polyclonal Antibody

 Also Known As   

Goat anti-TREM2 Antibody

 Product Synonym Names    TREM2; triggering receptor expressed on myeloid cells 2; TREM-2; Trem2a; Trem2b; Trem2c; OTTHUMP00000039771; triggering receptor expressed on myeloid cells 2a; TREM2 antibody; triggering receptor expressed on myeloid cells 2 antibody; TREM-2 antibody; Trem2a antibody; Trem2b antibody; Trem2c antibody; OTTHUMP00000039771 antibody; triggering receptor expressed on myeloid cells 2a antibody
 Product Gene Name   

anti-TREM2 antibody

[Similar Products]
 Antibody/Peptide Pairs    TREM2 peptide (MBS426601) is used for blocking the activity of TREM2 antibody (MBS420713)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    HGQKPGTHPP SELD
 OMIM    221770
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-HGQKPGTHPPSELD, from the C Terminus of the protein sequence according to NP_061838.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-TREM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TREM2 antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-TREM2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Spleen shows staining of macrophages. Recommended concentration, 2-3ug/ml.
Western Blot: Preliminary experiments gave bands at approx 80kDa and 30kDa in Human Brain (Cerebellum) lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 25.4kDa according to NP_061838.1. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
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 Immunohistochemistry (IHC) of anti-TREM2 antibody    (2.5ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-TREM2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TREM2. It may not necessarily be applicable to this product.
 NCBI GI #    9507203
 NCBI GeneID    54209
 NCBI Accession #    NP_061838.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_018965.3 [Other Products]
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 UniProt Secondary Accession #    Q8N5H8; Q8WYN6 [Other Products]
 UniProt Related Accession #    Q9NZC2 [Other Products]
 Molecular Weight    24,669 Da
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 NCBI Official Full Name    triggering receptor expressed on myeloid cells 2 isoform 1
 NCBI Official Synonym Full Names    triggering receptor expressed on myeloid cells 2
 NCBI Official Symbol    TREM2 [Similar Products]
 NCBI Official Synonym Symbols   
TREM-2; Trem2a; Trem2b; Trem2c
[Similar Products]
 NCBI Protein Information    triggering receptor expressed on myeloid cells 2
 UniProt Protein Name    Triggering receptor expressed on myeloid cells 2
 UniProt Synonym Protein Names   
Triggering receptor expressed on monocytes 2
 Protein Family    Triggering receptor expressed on myeloid cells
 UniProt Gene Name    TREM2 [Similar Products]
 UniProt Synonym Gene Names    TREM-2 [Similar Products]
 UniProt Entry Name    TREM2_HUMAN
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 NCBI Summary for TREM2    This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
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 UniProt Comments for TREM2    TREM2: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: extracellular region; integral to membrane; intracellular membrane-bound organelle; plasma membrane

Molecular Function: lipopolysaccharide binding; peptidoglycan binding; receptor activity

Biological Process: detection of lipopolysaccharide; detection of peptidoglycan; humoral immune response; innate immune response; phagocytosis, engulfment; positive regulation of antigen processing and presentation of peptide antigen via MHC class II; positive regulation of calcium-mediated signaling; positive regulation of peptidyl-tyrosine phosphorylation; regulation of immune response

Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
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 Research Articles on TREM2    1. Elevated expression of TREM2 is associated with Alzheimer's disease pathology.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TREM2 antibodyPathways associated with anti-TREM2 antibody
 Reference Product  PubMed Publications
 TYROBP antibody  >75 publications with TREM2 and TYROBP
 SYK antibody  >8 publications with TREM2 and SYK
 PLXNA1 antibody  >3 publications with TREM2 and PLXNA1
 VAV3 antibody  >1 publications with TREM2 and VAV3
 SEMA6D antibody  >1 publications with TREM2 and SEMA6D
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
Diseases associated with anti-TREM2 antibodyOrgans/Tissues associated with anti-TREM2 antibody
 Disease Name  Pubmed Publications
 Dementia Antibodies  >140 publications with TREM2 and Dementia
 Alzheimer Disease Antibodies  >113 publications with TREM2 and Alzheimer Disease
 Inflammation Antibodies  >71 publications with TREM2 and Inflammation
 Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy Antibodies  >29 publications with TREM2 and Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
 Disease Models, Animal Antibodies  >27 publications with TREM2 and Disease Models, Animal
 Necrosis Antibodies  >17 publications with TREM2 and Necrosis
 Lung Diseases Antibodies  >13 publications with TREM2 and Lung Diseases
 Memory Disorders Antibodies  >8 publications with TREM2 and Memory Disorders
 Cognition Disorders Antibodies  >7 publications with TREM2 and Cognition Disorders
 Cardiovascular Diseases Antibodies  >7 publications with TREM2 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >123 publications with TREM2 and Brain
 Lung Antibodies  >18 publications with TREM2 and Lung
 Eye Antibodies  >3 publications with TREM2 and Eye
 Ovary Antibodies  >2 publications with TREM2 and Ovary
 Kidney Antibodies  >1 publications with TREM2 and Kidney
 Adipose Tissue Antibodies  >1 publications with TREM2 and Adipose Tissue
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