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anti-TRH antibody :: Rabbit anti-Human TRH TRH Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS534472 anti-TRH antibody
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 Product Name   

TRH, Polyclonal Antibody

★Popular Item★
 Also Known As   

TRH antibody

 Product Synonym Names    Polyclonal TRH; Anti-TRH; Thyrotropin Releasing Hormone
 Product Gene Name   

anti-TRH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    613879
 3D Structure    ModBase 3D Structure for P20396
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 Clonality    Polyclonal
 Isotype    IgG1
 Host    Rabbit
 Species Reactivity    Human TRH
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 Form/Format    Supplied as whole antiserum containing 0.09% NaN3. Dilute in PBS immediately before use.
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 Biological Significance    Thyrotropin Releasing Hormone is produced in thehypothalamus and stimulates the release of ThyroidStimulating Hormone (TSH) in the pituitary.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    TRH antibody was raised in rabbit using a synthetic peptide conjugated with KLH as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-TRH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TRH antibody

   Rabbit polyclonal TRH antibody
 Product Categories/Family for anti-TRH antibody    Hormones & Steroids
 Applications Tested/Suitable for anti-TRH antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC)

 Application Notes for anti-TRH antibody    IHC: 1:50
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NCBI/Uniprot data below describe general gene information for TRH. It may not necessarily be applicable to this product.
 NCBI GI #    6005920
 NCBI GeneID    7200
 NCBI Accession #    NP_009048 [Other Products]
 NCBI GenBank Nucleotide #    NM_007117.4 [Other Products]
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 UniProt Primary Accession #    P20396 [Other Products]
 UniProt Secondary Accession #    Q2TB83; B2R8R1 [Other Products]
 UniProt Related Accession #    P20396 [Other Products]
 Molecular Weight    27,404 Da
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 NCBI Official Full Name    thyrotropin releasing hormone preproprotein
 NCBI Official Synonym Full Names    thyrotropin-releasing hormone
 NCBI Official Symbol    TRH [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    thyrotropin releasing hormone
 UniProt Protein Name    Pro-thyrotropin-releasing hormone
 UniProt Synonym Protein Names   
 Protein Family    Thyrotropin-releasing hormone
 UniProt Gene Name    TRH [Similar Products]
 UniProt Synonym Gene Names    Pro-TRH; TRH; TRF [Similar Products]
 UniProt Entry Name    TRH_HUMAN
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 NCBI Summary for TRH    This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]
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 UniProt Comments for TRH    TRH: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes. Belongs to the TRH family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q13.3-q21

Cellular Component: plasma membrane; extracellular region; nucleus; secretory granule

Molecular Function: neuropeptide hormone activity; thyrotropin-releasing hormone activity

Biological Process: hormone-mediated signaling; negative regulation of glutamate secretion; eating behavior; positive regulation of insulin secretion; histamine metabolic process; signal transduction; adult walking behavior; response to ethanol; cell-cell signaling; response to glucose stimulus; response to hypoxia; response to cold; positive regulation of gamma-aminobutyric acid secretion; response to corticosterone stimulus

Disease: Thyrotropin-releasing Hormone Deficiency
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 Research Articles on TRH    1. TRH, LH-RH and substance P are not affected in Alzheimer disease and Down's syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TRH antibodyPathways associated with anti-TRH antibody
 Reference Product  PubMed Publications
 PRL antibody  >1759 publications with TRH and PRL
 CCK antibody  >64 publications with TRH and CCK
 TRHR antibody  >52 publications with TRH and TRHR
 NTS antibody  >17 publications with TRH and NTS
 GRP antibody  >8 publications with TRH and GRP
 OXT antibody  >6 publications with TRH and OXT
 NPS antibody  >2 publications with TRH and NPS
 GNRH1 antibody  >1 publications with TRH and GNRH1
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Thyroxine (Thyroid Hormone) Production Pathway antibodies  Thyroxine (Thyroid Hormone) Production Pathway Diagram
Diseases associated with anti-TRH antibodyOrgans/Tissues associated with anti-TRH antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2010 publications with TRH and Nervous System Diseases
 Brain Diseases Antibodies  >1697 publications with TRH and Brain Diseases
 Depressive Disorder Antibodies  >335 publications with TRH and Depressive Disorder
 Disease Models, Animal Antibodies  >133 publications with TRH and Disease Models, Animal
 Hypertension Antibodies  >114 publications with TRH and Hypertension
 Seizures Antibodies  >94 publications with TRH and Seizures
 Weight Loss Antibodies  >91 publications with TRH and Weight Loss
 Hypothermia Antibodies  >91 publications with TRH and Hypothermia
 Pain Antibodies  >90 publications with TRH and Pain
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4695 publications with TRH and Brain
 Testis Antibodies  >104 publications with TRH and Testis
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