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anti-TRIB2 antibody :: Rabbit anti-Human TRIB2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS628598 anti-TRIB2 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRIB2, Polyclonal Antibody

 Also Known As   

TRIB2, NT (Tribbles Homolog 2, TRB-2, TRB2)

 Product Synonym Names    Anti -TRIB2, NT (Tribbles Homolog 2, TRB-2, TRB2)
 Product Gene Name   

anti-TRIB2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (12856998..12882860). Location: 2p24.3
 OMIM    609462
 3D Structure    ModBase 3D Structure for Q92519
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human TRIB2.
 Purity/Purification    Affinity Purified
Purified by ammonium sulfate precipitation.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
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 Immunogen    Synthetic peptide selected from the N-terminal region of human TRIB2 (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-TRIB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TRIB2 antibody

   TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.
 Product Categories/Family for anti-TRIB2 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-TRIB2 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-TRIB2 antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
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NCBI/Uniprot data below describe general gene information for TRIB2. It may not necessarily be applicable to this product.
 NCBI GI #    11056054
 NCBI GeneID    28951
 NCBI Accession #    NP_067675.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021643.3 [Other Products]
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 UniProt Primary Accession #    Q92519 [Other Products]
 UniProt Secondary Accession #    B2R851; D6W510 [Other Products]
 UniProt Related Accession #    Q92519 [Other Products]
 Molecular Weight    38,801 Da [Similar Products]
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 NCBI Official Full Name    tribbles homolog 2
 NCBI Official Synonym Full Names    tribbles homolog 2 (Drosophila)
 NCBI Official Symbol    TRIB2 [Similar Products]
 NCBI Official Synonym Symbols   
C5FW; TRB2; GS3955; FLJ57420
[Similar Products]
 NCBI Protein Information    tribbles homolog 2; OTTHUMP00000115687
 UniProt Protein Name    Tribbles homolog 2
 Protein Family    Tribbles
 UniProt Gene Name    TRIB2 [Similar Products]
 UniProt Synonym Gene Names    TRB2 [Similar Products]
 UniProt Entry Name    TRIB2_HUMAN
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 NCBI Summary for TRIB2    This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
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 UniProt Comments for TRIB2    TRB2: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; CAMK group; Trbl family

Chromosomal Location of Human Ortholog: 2p24.3

Cellular Component: cytoskeleton; cytoplasm

Molecular Function: protein kinase inhibitor activity; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity; nucleotide binding; transcription factor binding; protein kinase activity

Biological Process: negative regulation of interleukin-10 biosynthetic process; regulation of MAP kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein kinase activity; negative regulation of fat cell differentiation; protein amino acid phosphorylation
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 Research Articles on TRIB2    1. our data demonstrate that Trib2 can bind both COP1 and C/EBP-alpha, leading to degradation of C/EBP-alpha.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-TRIB2 antibodyOrgans/Tissues associated with anti-TRIB2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >14 publications with TRIB2 and Neoplasms
 Leukemia Antibodies  >13 publications with TRIB2 and Leukemia
 Leukemia, Myeloid Antibodies  >9 publications with TRIB2 and Leukemia, Myeloid
 Leukemia, Myeloid, Acute Antibodies  >7 publications with TRIB2 and Leukemia, Myeloid, Acute
 Nervous System Diseases Antibodies  >6 publications with TRIB2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >3 publications with TRIB2 and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with TRIB2 and Cell Transformation, Neoplastic
 Leukemia, Lymphocytic, Chronic, B-Cell Antibodies  >2 publications with TRIB2 and Leukemia, Lymphocytic, Chronic, B-Cell
 Uveitis Antibodies  >2 publications with TRIB2 and Uveitis
 Leukemia, T-Cell Antibodies  >2 publications with TRIB2 and Leukemia, T-Cell
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >2 publications with TRIB2 and Eye
 Lung Antibodies  >1 publications with TRIB2 and Lung
 Embryonic Tissue Antibodies  >1 publications with TRIB2 and Embryonic Tissue
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