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anti-TRIM23 antibody :: Rabbit anti-Human TRIM23 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7044622
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRIM23, Polyclonal Antibody

★Popular Item★
 Also Known As   

TRIM23 Antibody

 Product Synonym Names    E3 ubiquitin-protein ligase TRIM23; ADP-ribosylation factor domain-containing protein 1; GTP-binding protein ARD-1; RING finger protein 46; Tripartite motif-containing protein 23; TRIM23; ARD1; ARFD1; RNF46
 Product Gene Name   

anti-TRIM23 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601747
 3D Structure    ModBase 3D Structure for P36406
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human E3 ubiquitin-protein ligase TRIM23 protein (N-280AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-26292 / sc-130046
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TRIM23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TRIM23 antibody

   Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.
 Applications Tested/Suitable for anti-TRIM23 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-TRIM23 antibody    Western blot
All lanes: TRIM23 antibody at 2.67 ug/ml+ Raw264.7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 65,64,62 kDa
Observed band size: 64 kDa

anti-TRIM23 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TRIM23 antibody    Immunohistochemistry of paraffin-embedded human thyroid tissue using MBS7044622 at dilution of 1:100
anti-TRIM23 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TRIM23. It may not necessarily be applicable to this product.
 NCBI GI #    4502197
 NCBI GeneID    373
 NCBI Accession #    NP_001647.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001656.3 [Other Products]
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 UniProt Primary Accession #    P36406 [Other Products]
 UniProt Secondary Accession #    Q9BZY4; Q9BZY5 [Other Products]
 UniProt Related Accession #    P36406 [Other Products]
 Molecular Weight    61,068 Da
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 NCBI Official Full Name    E3 ubiquitin-protein ligase TRIM23 isoform alpha
 NCBI Official Synonym Full Names    tripartite motif containing 23
 NCBI Official Symbol    TRIM23 [Similar Products]
 NCBI Official Synonym Symbols   
ARD1; ARFD1; RNF46
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase TRIM23
 UniProt Protein Name    E3 ubiquitin-protein ligase TRIM23
 UniProt Synonym Protein Names   
ADP-ribosylation factor domain-containing protein 1; GTP-binding protein ARD-1; RING finger protein 46; Tripartite motif-containing protein 23
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    TRIM23 [Similar Products]
 UniProt Synonym Gene Names    ARD1; ARFD1; RNF46 [Similar Products]
 UniProt Entry Name    TRI23_HUMAN
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 NCBI Summary for TRIM23    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TRIM23    TRIM23: Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.-; Ligase

Chromosomal Location of Human Ortholog: 5q12.3

Cellular Component: Golgi membrane; lysosomal membrane

Molecular Function: enzyme activator activity; GDP binding; GTP binding; GTPase activity; identical protein binding; protein binding; ubiquitin-protein ligase activity

Biological Process: protein ubiquitination
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 Research Articles on TRIM23    1. TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARgamma2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-TRIM23 antibodyOrgans/Tissues associated with anti-TRIM23 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2 publications with TRIM23 and Necrosis
 Liver Diseases Antibodies  >1 publications with TRIM23 and Liver Diseases
 Adenocarcinoma Antibodies  >1 publications with TRIM23 and Adenocarcinoma
 Kidney Diseases Antibodies  >1 publications with TRIM23 and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with TRIM23 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with TRIM23 and Neoplasm Metastasis
 Carcinoma, Hepatocellular Antibodies  >1 publications with TRIM23 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with TRIM23 and Liver
 Blood Antibodies  >3 publications with TRIM23 and Blood
 Muscle Antibodies  >1 publications with TRIM23 and Muscle
 Connective Tissue Antibodies  >1 publications with TRIM23 and Connective Tissue
 Vascular Antibodies  >1 publications with TRIM23 and Vascular
 Brain Antibodies  >1 publications with TRIM23 and Brain
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