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anti-Trim30 antibody :: Rabbit anti-Mouse, Rat TRIM30 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150767
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRIM30, Polyclonal Antibody

 Also Known As   

TRIM30 Antibody

 Product Synonym Names    TRIM30; Rpt1; Rpt-1; Trim30; Rpt1; Tripartite motif-containing protein 30A; Down regulatory protein of interleukin-2 receptor; tripartite motif-containing 30
 Product Gene Name   

anti-Trim30 antibody

[Similar Products]
 Antibody/Peptide Pairs    TRIM30 peptide (MBS152756) is used for blocking the activity of TRIM30 antibody (MBS150767)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P15533
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse, Rat
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 Purity/Purification    TRIM30 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    TRIM30 antibody was raised against a 24 amino acid synthetic peptide near the amino terminus of the mouse TRIM30.
 Buffer    TRIM30 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    TRIM30 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-Trim30 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Trim30 antibody

   TRIM30 Antibody: TRIM30 belongs to a family of the tripartite motif (TRIM) proteins involved in the regulation of cell proliferation, differentiation, development, oncogenesis, apoptosis and antiviral responses. The TRIM protein family is an expanding family of RING ('really interesting new gene') proteins, also known as RBCC proteins as they contain an RBCC motif, which comprises a RING domain, one or two B-boxes and a predicted coiled-coil region. Studies have shown that some TRIM family members are critical to innate immunity; TRIM5, TRIM19 and TRIM25, for example, have been shown to restrict viral infection. A recent study shows that TRIM30 functions as a negative modulator of the TLR signaling pathway, by targeting TAB2 and TAB3, and contributes to the inhibition of TLR-mediated NF-κB activation. The importance of TRIM30 in the attenuation or termination of NF-κB activation suggests that targeting of TAB2 and TAB3 by TRIM30alpha may be a mechanism for modulating many types of immune responses.
 Applications Tested/Suitable for anti-Trim30 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-Trim30 antibody    TRIM30 antibody can be used for detection of TRIM30 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-Trim30 antibody    Western blot analysis of TRIM30 in mouse heart tissue lysate with TRIM30 antibody at (A) 1 and (B) 2 μg/mL.
anti-Trim30 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-Trim30 antibody    Immunohistochemistry of TRIM30 in mouse ovary tissue with TRIM30 antibody at 10 μg/mL.
anti-Trim30 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-Trim30 antibody    Immunofluorescence of TRIM30 in Human Ovary cells with TRIM30 antibody at 20 μg/mL.
anti-Trim30 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for Trim30. It may not necessarily be applicable to this product.
 NCBI GI #    125347379
 NCBI GeneID    20128
 NCBI Accession #    NP_033125 [Other Products]
 NCBI GenBank Nucleotide #    NM_009099.2 [Other Products]
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 UniProt Primary Accession #    P15533 [Other Products]
 UniProt Secondary Accession #    Q3UV85; Q3UZ29; Q99K55; Q99PQ7; Q99PQ8; Q99PQ9 [Other Products]
 UniProt Related Accession #    P15533 [Other Products]
 Molecular Weight    17,414 Da
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 NCBI Official Full Name    tripartite motif-containing protein 30A
 NCBI Official Synonym Full Names    tripartite motif-containing 30A
 NCBI Official Symbol    Trim30a [Similar Products]
 NCBI Official Synonym Symbols   
Rpt1; Rpt-1; Trim30
[Similar Products]
 NCBI Protein Information    tripartite motif-containing protein 30A; tripartite motif protein 30; tripartite motif-containing 30; regulatory protein, T lymphocyte 1; down regulatory protein of interleukin-2 receptor
 UniProt Protein Name    Tripartite motif-containing protein 30A
 UniProt Synonym Protein Names   
Down regulatory protein of interleukin-2 receptor; Tripartite motif-containing protein 30
 UniProt Gene Name    Trim30a [Similar Products]
 UniProt Synonym Gene Names    Rpt-1; Rpt1; Trim30 [Similar Products]
 UniProt Entry Name    TR30A_MOUSE
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 UniProt Comments for Trim30    TRIM30A: Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses

Cellular Component: cytoplasm; intracellular; nucleus

Molecular Function: DNA binding; zinc ion binding; metal ion binding

Biological Process: protein autoubiquitination; transcription, DNA-dependent; positive regulation of virion penetration into host cell; regulation of transcription, DNA-dependent; positive regulation of protein catabolic process; negative regulation of interleukin-6 production; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production
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 Research Articles on Trim30    1. These results indicate a distinct requirement for TRIM30 in modulation of NF-kappaB activation and cell proliferation induced by TCR stimulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Trim30 antibodyOrgans/Tissues associated with anti-Trim30 antibody
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with Trim30 and Blood
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