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anti-TRIM33 antibody :: Rabbit anti-Human TRIM33 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9213223
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRIM33, Polyclonal Antibody

★Popular Item★
 Also Known As   

TRIM33 Antibody (C-term)

 Product Synonym Names    E3 ubiquitin-protein ligase TRIM33; 632-; Ectodermin homolog; RET-fused gene 7 protein; Protein Rfg7; Transcription intermediary factor 1-gamma; TIF1-gamma; Tripartite motif-containing protein 33; TRIM33; KIAA1113; RFG7; TIF1G
 Product Gene Name   

anti-TRIM33 antibody

[Similar Products]
 Antibody/Peptide Pairs    TRIM33 peptide (MBS9220071) is used for blocking the activity of TRIM33 antibody (MBS9213223)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    820-849
 OMIM    188550
 3D Structure    ModBase 3D Structure for Q9UPN9
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This TRIM33 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 820-849 amino acids from the C-terminal region of human TRIM33.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
 Cellular Location    Nucleus. Note=In discrete nuclear dots resembling nuclear bodies.
 Tissue Location    Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-TRIM33 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TRIM33 antibody

   The protein encoded by this gene is thought to be a
transcriptional corepressor. However, molecules that interact with
this protein have not yet been identified. The protein is a member
of the tripartite motif family. This motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
and a coiled-coil region. Three alternatively spliced transcript
variants for this gene have been described, however, the
full-length nature of one variant has not been determined.

Function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade).
 Product Categories/Family for anti-TRIM33 antibody    Signal Transduction
 Applications Tested/Suitable for anti-TRIM33 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-TRIM33 antibody    WB~~1:1000
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 Western Blot (WB) of anti-TRIM33 antibody    TRIM33 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TRIM33 antibody detected the TRIM33 protein (arrow).
anti-TRIM33 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TRIM33. It may not necessarily be applicable to this product.
 NCBI GI #    74027249
 NCBI GeneID    51592
 NCBI Accession #    NP_056990.3 [Other Products]
 NCBI Related Accession #    NP_148980.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_015906.3 [Other Products]
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 UniProt Primary Accession #    Q9UPN9 [Other Products]
 UniProt Secondary Accession #    O95855; Q5TG72; Q5TG73; Q5TG74; Q9C017; Q9UJ79 [Other Products]
 UniProt Related Accession #    Q9UPN9 [Other Products]
 Molecular Weight    122533
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 NCBI Official Full Name    E3 ubiquitin-protein ligase TRIM33 isoform alpha
 NCBI Official Synonym Full Names    tripartite motif containing 33
 NCBI Official Symbol    TRIM33 [Similar Products]
 NCBI Official Synonym Symbols   
ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase TRIM33
 UniProt Protein Name    E3 ubiquitin-protein ligase TRIM33
 UniProt Synonym Protein Names   
Ectodermin homolog; RET-fused gene 7 protein; Protein Rfg7; Transcription intermediary factor 1-gamma; TIF1-gamma; Tripartite motif-containing protein 33
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    TRIM33 [Similar Products]
 UniProt Synonym Gene Names    KIAA1113; RFG7; TIF1G; Protein Rfg7; TIF1-gamma [Similar Products]
 UniProt Entry Name    TRI33_HUMAN
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 NCBI Summary for TRIM33    The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TRIM33    TIF1G: an atypical protein kinase that functions as a transcriptional repressor. Translocation with RET generates the TRIM33/RET (PTC7) oncogene. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Two splice variant isoforms have been described.

Protein type: EC 6.3.2.19; Ligase; EC 6.3.2.-; Protein kinase, atypical; Kinase, protein; Transcription, coactivator/corepressor; Ubiquitin ligase; Ubiquitin conjugating system; ATYPICAL group; TIF1 family

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transforming growth factor beta receptor signaling pathway; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; protein ubiquitination; gene expression; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of BMP signaling pathway

Disease: Thyroid Carcinoma, Papillary
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Product References and Citations for anti-TRIM33 antibody

   Bai, X., et al. Cell 142(1):133-143(2010)
Howard, P.W., et al. Biochem. Biophys. Res. Commun. 396(3):674-678(2010)
Vincent, D.F., et al. PLoS Genet. 5 (7), E1000575 (2009) :
Dupont, S., et al. Cell 136(1):123-135(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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 Research Articles on TRIM33    1. The dermatomyositis autoantigen TIF1gamma is markedly up-regulated during muscle regeneration in human and mouse muscle cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TRIM33 antibodyPathways associated with anti-TRIM33 antibody
 Reference Product  PubMed Publications
 SMAD4 antibody  >27 publications with TRIM33 and SMAD4
 SMAD2 antibody  >9 publications with TRIM33 and SMAD2
 TRIM24 antibody  >4 publications with TRIM33 and TRIM24
 SMAD3 antibody  >4 publications with TRIM33 and SMAD3
 LDB1 antibody  >1 publications with TRIM33 and LDB1
 Products by Pathway  Pathway Diagram
 RNA Polymerase Pathway antibodies  RNA Polymerase Pathway Diagram
 RNA Polymerase Pathway antibodies  RNA Polymerase Pathway Diagram
 RNA Polymerase Pathway antibodies  RNA Polymerase Pathway Diagram
 RNA Polymerase Pathway antibodies  RNA Polymerase Pathway Diagram
 RNA Polymerase Pathway antibodies  RNA Polymerase Pathway Diagram
 RNA Polymerase Pathway antibodies  RNA Polymerase Pathway Diagram
Diseases associated with anti-TRIM33 antibodyOrgans/Tissues associated with anti-TRIM33 antibody
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >4 publications with TRIM33 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >4 publications with TRIM33 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with TRIM33 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >4 publications with TRIM33 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with TRIM33 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >2 publications with TRIM33 and Neoplasms, Experimental
 Fibrosis Antibodies  >2 publications with TRIM33 and Fibrosis
 Inflammation Antibodies  >2 publications with TRIM33 and Inflammation
 Liver Neoplasms, Experimental Antibodies  >1 publications with TRIM33 and Liver Neoplasms, Experimental
 Precancerous Conditions Antibodies  >1 publications with TRIM33 and Precancerous Conditions
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with TRIM33 and Blood
 Bone Antibodies  >7 publications with TRIM33 and Bone
 Lung Antibodies  >7 publications with TRIM33 and Lung
 Liver Antibodies  >6 publications with TRIM33 and Liver
 Embryonic Tissue Antibodies  >5 publications with TRIM33 and Embryonic Tissue
 Bone Marrow Antibodies  >4 publications with TRIM33 and Bone Marrow
 Brain Antibodies  >4 publications with TRIM33 and Brain
 Connective Tissue Antibodies  >3 publications with TRIM33 and Connective Tissue
 Mammary Gland Antibodies  >3 publications with TRIM33 and Mammary Gland
 Skin Antibodies  >3 publications with TRIM33 and Skin
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