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anti-TRIM5 antibody :: Rabbit anti-Human TRIM5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240305
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRIM5, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal to Human TRIM5

 Product Synonym Names    Anti-TRIM5 Antibody IHC-plus; TRIM5; RNF88; RING finger protein 88; Tripartite motif containing 5; TRIM5alpha; Tripartite motif protein TRIM5; Tripartite motif-containing 5; Human TRIM5
 Product Gene Name   

anti-TRIM5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608487
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    synthetic peptide corresponding to amino acids near the mid-region of human TRIM5a
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human TRIM5.
 Immunogen Type    Synthetic peptide
 Immunogen    TRIM5 antibody was raised against synthetic peptide from human TRIM5.
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-TRIM5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TRIM5 antibody

   TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the a variant which also contains a carboxy-terminal B30.2 (SPRY) domain (1).
 Product Categories/Family for anti-TRIM5 antibody    Family: Tripartite Motif
 Applications Tested/Suitable for anti-TRIM5 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-TRIM5 antibody    IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-TRIM5 antibody    Anti-TRIM5 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
anti-TRIM5 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-TRIM5 antibody    Immunofluorescence of TRIM5 alpha in Human Stomach cells with TRIM5 alpha antibody at 10 ug/ml.
anti-TRIM5 antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-TRIM5 antibody    Western blot of TRIM5 alpha expression in human stomach (A), thymus (B), and uterus (C) cell lysate with TRIM5 alpha antibody at 2 ug /ml.
anti-TRIM5 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TRIM5. It may not necessarily be applicable to this product.
 NCBI GI #    336088646
 NCBI GeneID    85363
 NCBI Accession #    NP_149023.2 [Other Products]
 NCBI GenBank Nucleotide #    NG_029122.1 [Other Products]
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 UniProt Secondary Accession #    Q2MLV4; Q2MLV8; Q2MLV9; Q2MLW1; Q2MLW3; Q2MLW4; A6NGQ1; A8WFA8; D3DQS8; D3DQS9; G3GJY1 [Other Products]
 UniProt Related Accession #    Q9C035 [Other Products]
 Molecular Weight    29,677 Da
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 NCBI Official Full Name    Homo sapiens tripartite motif containing 5 (TRIM5), RefSeqGene on chromosome 11
 NCBI Official Synonym Full Names    tripartite motif containing 5
 NCBI Official Symbol    TRIM5 [Similar Products]
 NCBI Official Synonym Symbols   
RNF88; TRIM5alpha
[Similar Products]
 NCBI Protein Information    tripartite motif-containing protein 5; ring finger protein 88; tripartite motif protein TRIM5; tripartite motif containing 5 transcript variant iota; tripartite motif containing 5 transcript variant kappa
 UniProt Protein Name    Tripartite motif-containing protein 5
 UniProt Synonym Protein Names   
RING finger protein 88
 Protein Family    Tripartite motif-containing protein
 UniProt Gene Name    TRIM5 [Similar Products]
 UniProt Synonym Gene Names    RNF88 [Similar Products]
 UniProt Entry Name    TRIM5_HUMAN
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 NCBI Summary for TRIM5    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]
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 UniProt Comments for TRIM5    TRIM5: Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity. Belongs to the TRIM/RBCC family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ligase

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: cytoplasm; cytosol

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; zinc ion binding; ubiquitin-protein ligase activity; pattern recognition receptor activity; ligase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAPKKK cascade; viral reproduction; negative regulation of virion penetration into host cell; cytokine and chemokine mediated signaling pathway; innate immune response; positive regulation of transcription factor activity; pattern recognition receptor signaling pathway; defense response to virus; activation of innate immune response; regulation of lipopolysaccharide-mediated signaling pathway; activation of NF-kappaB transcription factor
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 Research Articles on TRIM5    1. TRIM5alpha variations influence transduction efficiency with lentiviral vectors in both human and rhesus CD34(+) cells in vitro and in vivo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TRIM5 antibodyDiseases associated with anti-TRIM5 antibody
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 HIV Infections Antibodies  >156 publications with TRIM5 and HIV Infections
 Disease Models, Animal Antibodies  >18 publications with TRIM5 and Disease Models, Animal
 Inflammation Antibodies  >7 publications with TRIM5 and Inflammation
 Nervous System Diseases Antibodies  >3 publications with TRIM5 and Nervous System Diseases
 Kidney Diseases Antibodies  >3 publications with TRIM5 and Kidney Diseases
 Necrosis Antibodies  >2 publications with TRIM5 and Necrosis
 Hepatitis Antibodies  >1 publications with TRIM5 and Hepatitis
 Acidosis Antibodies  >1 publications with TRIM5 and Acidosis
 Mental Disorders Antibodies  >1 publications with TRIM5 and Mental Disorders
Organs/Tissues associated with anti-TRIM5 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >52 publications with TRIM5 and Blood
 Kidney Antibodies  >9 publications with TRIM5 and Kidney
 Bone Marrow Antibodies  >3 publications with TRIM5 and Bone Marrow
 Bone Antibodies  >3 publications with TRIM5 and Bone
 Heart Antibodies  >3 publications with TRIM5 and Heart
 Intestine Antibodies  >2 publications with TRIM5 and Intestine
 Lung Antibodies  >2 publications with TRIM5 and Lung
 Prostate Antibodies  >2 publications with TRIM5 and Prostate
 Embryonic Tissue Antibodies  >1 publications with TRIM5 and Embryonic Tissue
 Connective Tissue Antibodies  >1 publications with TRIM5 and Connective Tissue
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